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CDKN1C


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Symbol:CDKN1C
Name(s):cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Type:protein-coding
Organism:Homo sapiens
Synonyms:BWCR, BWS, KIP2, WBS, p57
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15821902 Observational study of gene-disease association. (HuGE Navigator)
17351341 Observational study of gene-disease association. (HuGE Navigator)
17986608 demonstrate that these myoblasts are unable to complete myogenic differentiation because of an inability to up-regulate p57Kip2 transcription
17464323 mechanism whereby p57(Kip2) influences the mitochondrial apoptotic cell death pathway in cancer cells
17885492 We did not find p16, p14, and p57 to be useful as prognostic markers in stage III ovarian cancer
17572845 In this study, P57kip2 immunostaining was absent in the trophoblastic layers of CHM and was positive in the trophoblast layer of nonmolar villi and MD.
12586619 frequently methylated in adult patients with ALL, and that inactivation of a pathway composed of p73, p15, and p57KIP2 predicts for poor prognosis in Ph-negative patients
15985436 identification of a novel p73-Kip2/p57 pathway that coordinates mitotic exit and transition to G1
12925736 SCFSkp2 complex plays an important role in cell-cycle progression by determining the abundance of p57Kip2 and that of the related CDK inhibitor p27Kip1.
15492797 Aberrant methylation of p57KIP2 gene is associated with lung and breast cancers and malignant mesotheliomas

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCyclin dependent kinase inhibitor 1CLIM domain kinase 1--Pubmed
HPRDCyclin dependent kinase inhibitor 1Cmyogenic differentiation 1--Pubmed
HPRDCyclin dependent kinase inhibitor 1CS-phase kinase-associated protein 2 isoform 1--Pubmed
BINDHomo sapiens chromosome 11, reference assembly.-Miz1 interacts with p-P57KIP2.-Pubmed
HPRDcyclin-dependent kinase inhibitor 1C isoform aProliferating cell nuclear antigen--Pubmed
HPRDcyclin-dependent kinase inhibitor 1C isoform aMyogenic differentiation antigen 1--Pubmed
HPRDcyclin-dependent kinase inhibitor 1C isoform aS phase kinase associated protein 2--Pubmed
HPRDcyclin-dependent kinase inhibitor 1C isoform aLIM domain kinase 1--Pubmed

Recent Publications on CDKN1C:

Pubmed Logo
MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells.
Human embryonic stem (ES) cells exhibit a shorter G(1) cell cycle phase...
31st October, 2009
Morgridge Institute for Research, Madison, Wisconsin, USA. Stem Cells. 2009 Jul;27(7):1524-8.
DOI Direct Link
Hsa-miR-222 is involved in differentiation of endometrial stromal cells in vitro.
Decidualization is a critical step during embryo implantation and...
23rd October, 2009
Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Endocrinology. 2009 Oct;150(10):4734-43. Epub 2009 Jul 9.
DOI Direct Link
A case of Beckwith-Wiedemann syndrome caused by a cryptic 11p15 deletion encompassing the centromeric imprinted domain of the BWS locus.
Beckwith-Wiedemann syndrome is a clinically variable and genetically...
22nd October, 2009
1 Istituto di Genetica Medica, Universita Cattolica Sacro Cuore, J Med Genet. 2009 Oct 20.
DOI Direct Link
KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2).
Kruppel-like factor 4 (KLF4) belongs to a family of evolutionarily...
22nd October, 2009
Nanyang Technological University, Singapore, Singapore. Apoptosis. 2009 Sep;14(9):1095-107.
DOI Direct Link
Identification of novel regulators of hematopoietic stem cell development through refinement of stem cell localization and expression profiling.
The first adult-repopulating hematopoietic stem cells (HSCs) are detected...
2nd October, 2009
Department of Haematology, Cambridge Institute for Medical Research, Blood. 2009 Sep 30.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7229760 mRNA amplification
7251568 Methods and compositions for regulating bone and cartilage formation
7255987 Selecting animals for parentally imprinted traits

View more patents.

CDKN1C results (if any) from reagent suppliers

Google CSE Logo
Antibodies to Cell Cycle Regulators
human ... CDKN1C(1028), mouse (predicted), bovine, human, IP, WB, pricing ... human ... CDKN1C(1028), human, mouse, ARR, ELISA (i), IP, WB, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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p57 (KP39) Antibody sc-56341
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CDKN1C, 1028, 11p15.4, NM_000076 ...
http://www.scbt.com/datasheet-56341-p57-kp39-antibody.html...

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P2735 Monoclonal Anti-p57Kip2 antibody produced in mouse clone ...
microarray: suitable. isotype, IgG2b. Gene Information, human ... CDKN1C(1028). mouse ... Cdkn1c(12577). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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CD-CY
HPA002924, Anti-CDKN1C antibody produced in rabbit, affinity isolated antibody, human ... CDKN1C(1028), human, IHC (p), PA, WB, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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IVD DATA SHEET
p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. ...
http://www.labvision.com/pdf/ivd/1062%20(ivd).pdf...

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P1-PC
human ... CDKN1C(1028), mouse (predicted), bovine, human, IP, WB, pricing ..... human ... CDKN1C(1028), human, mouse, ARR, ELISA (i), IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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p57Kip2 Ab-6 (Clone 57P06; same as KP10)
Description: p57Kip2 (or CDKN1C) is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. ...
http://www.labvision.com/pdf/1062.pdf...

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