BioPortfolio - CDKN2A - cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

CDKN2A

Symbol:

CDKN2A

Name(s):

cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, TP16, p14, p14ARF, p16, p16INK4, p16INK4a, p19

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

18239974

Alterations of SH3GL2 and CDKN2A loci have a synergistic role in the development of early-onset breast cancer.

18038118

mutant p53 loses its ability to suppress DNMT1 expression, and thus enhances methylation levels of the p16 ( ink4A ) promoter and subsequently down-regulates p16(ink4A )protein.

18334837

Large-scale analysis of cell cycle regulators in urothelial bladder cancer identifies p16 and p27 as potentially useful prognostic markers

18334838

p16 appears not to be directly involved in the development of sinonasal or urothelial inverted papilloma.

18306932

Analysis of the pattern of expression of these biomolecules showed increased p16-positive phenotypes and decreased cyclin D1- and pRB-positive phenotype among the invasive tumors compared to low-grade CIN lesions

18199718

Observational study of gene-disease association. (HuGE Navigator)

18210030

Observational study of gene-disease association. (HuGE Navigator)

18281541

Observational study of gene-disease association. (HuGE Navigator)

18327804

Observational study of gene-disease association. (HuGE Navigator)

18340101

Genome-wide association study of gene-disease association. (HuGE Navigator)

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