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CDKN2B


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Symbol:CDKN2B
Name(s):cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18281541 Observational study of gene-disease association. (HuGE Navigator)
18210030 Observational study of gene-disease association. (HuGE Navigator)
18071362 Inactivation of CDKN2A and B genes constitute an important step in chordoma development.
11668523 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)
12556369 Observational study of genotype prevalence. (HuGE Navigator)
15523694 Observational study of gene-disease association. (HuGE Navigator)
15960923 Observational study of gene-disease association. (HuGE Navigator)
17008550 Observational study of gene-disease association. (HuGE Navigator)
17409409 Observational study of gene-disease association. (HuGE Navigator)
17459456 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcyclin-dependent kinase 4cyclin-dependent kinase inhibitor 2B isoform 1--Pubmed
HPRDcyclin-dependent kinase 4cyclin-dependent kinase inhibitor 2B isoform 1--Pubmed
HPRDCyclin dependent kinase 8cyclin-dependent kinase inhibitor 2B isoform 1--Pubmed
HPRDcyclin-dependent kinase 8Cyclin dependent kinase inhibitor 2B--Pubmed
BINDHomo sapiens chromosome 9-Miz1 interacts with p-p15Ink4b.-Pubmed
HPRDcyclin-dependent kinase inhibitor 2B isoform 1zinc finger and BTB domain containing 17--Pubmed
HPRDcyclin-dependent kinase inhibitor 2B isoform 1zinc finger and BTB domain containing 17--Pubmed

Recent Publications on CDKN2B:

Pubmed Logo
Retinoblastoma 1 Protein Modulates XY Germ Cell Entry into G1/G0 Arrest During Fetal Development in Mice.
During mouse germ cell development, the first sign of sex differentiation...
30th October, 2009
Biol Reprod. 2009 Oct 28.
DOI Direct Link
PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
BACKGROUND: Recent advance in genetic studies added the confirmed...
29th October, 2009
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University PLoS One. 2009 Oct 28;4(10):e7643.
DOI Direct Link
Homozygous deletion of CDKN2A (p16, p14) and CDKN2B (p15) genes is a poor prognostic factor in adult but not in childhood B-lineage acute lymphoblastic leukemia: a comparative deletion and hypermethylation study.
The biological behavior of childhood B-lineage acute lymphoblastic...
20th October, 2009
Department of Laboratory Medicine, Seoul National University Hospital, Cancer Genet Cytogenet. 2009 Nov;195(1):59-65.
DOI Direct Link
Genetic mapping of the sex-linked barring gene in the chicken.
The sex-linked barring gene of the chicken (Gallus gallus), first...
30th September, 2009
Department of Poultry Science, North Carolina State University, Raleigh Poult Sci. 2009 Sep;88(9):1811-7.
DOI Direct Link
Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.
OBJECTIVE: We have investigated the functional significance of conserved...
30th September, 2009
University of Ottawa Heart Institute, Ottawa, Canada. Arterioscler Thromb Vasc Biol. 2009 Oct;29(10):1671-7. Epub 2009 Jul 10.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Diagnostic Study of Gene Alterations in Children Who Have Been Treated for Relapsed Acute Lymphocytic Leukemia

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7251568 Methods and compositions for regulating bone and cartilage formation
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof
7229760 mRNA amplification
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

View more patents.

CDKN2B results (if any) from reagent suppliers

Google CSE Logo
Alternative names for p15 INK4b antibody (ab26094)
CDK inhibitory protein antibody; CDK4B Inhibitor antibody; CDKN2B antibody; Cyclin dependent kinase 4 inhibitor B antibody; Cyclin Dependent Kinase ...
http://www.abcam.com/assets/popups/alternative-names.htm?int...

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p15 (K-18) Antibody sc-613
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CDKN2B, 1030, 9p21.3, NM_004936, ...
http://www.scbt.com/datasheet-613-p15-k-18-antibody.html...

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Anti-p15 Polyclonal Antibody
The PA1-24258 immunogen is a synthetic peptide corresponding to a region of human CDKN2B. p15 interacts strongly with cdk4 and cdk6. ...
http://www.bioreagents.com/products/productDetails/productDe...

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Abgent - Phosphorylation Antibodies - Phosphorylation
AT1481a, CDKN1B monoclonal antibody (M01), ELISA,IF,IHC-P,S-ELISA,WB-Ce,WB-Re, H . AT1482a, CDKN2B monoclonal antibody (M02), ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...

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Search Results
Anti-CDKN2B antibody produced in rabbit (1). 別名: Anti-Cyclin-dependent kinase inhibitor 2B (p15, ... Monoclonal Anti-CDKN2B antibody produced in mouse (1) ...
http://www.sigmaaldrich.com/catalog/Lookup.do?D7=0&D10=CDK4&...

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p15 (M-20) Antibody sc-1429
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Cdkn2b, 12579, 4 C4, P55271 ...
http://www.scbt.com/datasheet-1429-p15-m-20-antibody.html...

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TFDP1 antibody, TFDP1 (transcription factor Dp-1) Antibody, Rabbit ...
... CDK4 (cyclin-dependent kinase 4), CDK4 (cyclin-dependent kinase 4), CDK6 ( cyclin-dependent kinase 6), CDKN2B (cyclin-dependent kinase inhibito. ...
http://www.genwaybio.com/product_info.php?products_id=43022...

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