BioPortfolio - GNB2L1 - guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

GNB2L1

Symbol:

GNB2L1

Name(s):

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

17936896

RACK1 therefore exerts a tonic inhibitory effect on cell contact guidance, while positively promoting an adhesive phenotype

17965024

that intracellular calcium levels can regulate HIF-1alpha expression by modulating calcineurin activity and RACK1 dimerization.

17875659

These results suggest that PKCepsilon signaling in the basal airway cell may involve RACK1; however, PKCepsilon regulation in ciliated cells uses RACK1-independent pathways.

17875644

SSAT1, which shares 46% amino acid identity with SSAT2, also binds to HIF-1alpha and promotes its ubiquitination/degradation. However, in contrast to SSAT2, SSAT1 acts by stabilizing the interaction of HIF-1alpha with RACK1

17900862

Examine interactions between phosphodiesterase 4D5 (PDE4D5) and beta-arrestin and RACK1.

17574549

These findings support a novel role for RACK1 as a key regulator of cell migration and adhesion dynamics through the regulation of Src activity, and the modulation of paxillin phosphorylation at early adhesions.

17409124

Model a RACK1 proteome consisting of PKCepsilon-RACK1-NHERF1-NHERF1-tubulin with a role in stable expression of CFTR in the apical plasma membrane of epithelial cells.

11956211

Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor.

17201176

Dpl interacts with RACK1 by means of its structured globular carboxyl-terminal region

16061178

RACK1, the receptor for activated C kinase 1, serves as an adaptor for PKC-mediated JNK activation.

→View more information from publications.

Recent Publications on GNB2L1:

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase.
Focal Adhesion Kinase (FAK) activity is controlled by growth factors and...

29th September, 2009

From the Cell Biology Laboratory, Department of Biochemistry, BioSciences

J Biol Chem. 2009 Jul 24;284(30):20263-74. Epub 2009 May 7.
DOI Direct Link

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5.
Beta-arrestin plays a key role in regulating beta2-adrenoreceptor...

21st August, 2009

Neuroscience and Molecular Pharmacology, Wolfson and Davidson Buildings,

J Biol Chem. 2009 Jun 12;284(24):16170-82. Epub 2009 Apr 16.
DOI Direct Link

Regulation of magnesium reabsorption in DCT.
The distal convoluted tubule (DCT) is the shortest segment of the nephron...

25th July, 2009

Department of Physiology, Nijmegen Centre for Molecular Life Sciences,

Pflugers Arch. 2009 May;458(1):89-98. Epub 2008 Oct 24.
DOI Direct Link

Stxbp4 regulates DeltaNp63 stability by suppression of RACK1-dependent degradation.
p63, a member of the p53 tumor suppressor family, is essential for the...

14th July, 2009

Department of Biological Sciences, Columbia University, New York, NY

Mol Cell Biol. 2009 Jul;29(14):3953-63. Epub 2009 May 18.
DOI Direct Link

Diacylglycerol kinase delta associates with receptor for activated C kinase 1, RACK1.
The delta-isozyme (type II) of diacylglycerol kinase (DGK) is known to...

1st July, 2009

Department of Biochemistry, Sapporo Medical University School of Medicine,

Biochim Biophys Acta. 2009 Apr;1791(4):246-53. Epub 2009 Feb 7.
DOI Direct Link

→View more research publications.

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GNB2L1

Gene Information from Publications

Interacting gene products

Recent Publications on GNB2L1:

Patents:

GNB2L1 results (if any) from reagent suppliers