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VAV3


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Gene DB Home
Symbol:VAV3
Name(s):vav 3 guanine nucleotide exchange factor
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ40431
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15708849 TCR-induced association of Vav3 with SLP-76 is required for its membrane/IS localization and function
16384856 Vav3 levels rise during prostate cancer progression to androgen independence.
11805146 Vav3 regulates the B cell responses by promoting the sustained production of PIP3 and thereby calcium flux
12400014 We present here a novel stimulatory mechanism of Vav3 in which APS directly relieves the autoinhibitory CH domain and furthermore enhances its tyrosine phosphorylation by Lck.
15456756 results demonstrate that Vav3 and Vav1 play crucial but redundant roles in the activation of phospholipase C gamma 2 by glycoprotein GPVI
16762975 Vav3 oncogene is overexpressed and regulates cell growth and androgen receptor activity in human prostate cancer development and progression.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDRhoAvav 3 oncogene--Pubmed
HPRDRas homolog gene family, member Gvav 3 oncogene--Pubmed
HPRDras homolog gene family, member GVAV3--Pubmed
HPRDEGF receptorvav 3 oncogene--Pubmed
HPRDepidermal growth factor receptor oncogene homolog, avian)VAV3--Pubmed
HPRDGrb2vav 3 oncogene--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1VAV3--Pubmed
HPRDIGF-I receptorvav 3 oncogene--Pubmed
HPRDinsulin-like growth factor 1 receptor precursorVAV3--Pubmed
HPRDInsulin receptorvav 3 oncogene--Pubmed

Recent Publications on VAV3:

Pubmed Logo
B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin.
Antigen binding to the B cell antigen receptor (BCR) initiates an array of...
6th October, 2009
Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, J Biol Chem. 2009 Sep 4;284(36):24088-97. Epub 2009 Jul 8.
DOI Direct Link
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
Platelet response to activation varies widely between individuals but...
24th September, 2009
Department of Cardiovascular Science, University of Leicester, Clinical Blood. 2009 Aug 13;114(7):1405-16. Epub 2009 May 8.
DOI Direct Link
Osteopetrosis with micro-lacunar resorption because of defective integrin organization.
In vitro differentiated monocytes were used to characterize the cellular...
19th September, 2009
Department of Pathology, University of Pittsburgh, and Veteran's Affairs Lab Invest. 2009 Sep;89(9):1007-17. Epub 2009 Jun 22.
DOI Direct Link
Syk tyrosine 317 negatively regulates osteoclast function via the ubiquitin-protein isopeptide ligase activity of Cbl.
Cytoskeletal organization of the osteoclast (OC), which is central to the...
2nd September, 2009
Department of Pathology and Immunology, Washington University School of J Biol Chem. 2009 Jul 10;284(28):18833-9. Epub 2009 May 6.
DOI Direct Link
Major signaling pathways in migrating neuroblasts.
Neuronal migration is a key process in the developing and adult brain....
12th August, 2009
Department of Clinical Neurobiology, Interdisciplinary Center for Front Mol Neurosci. 2009;2:7. Epub 2009 Jul 24.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598052 Expression profile of thyroid cancer
7550300 Prediction of bare metal stent restenosis
7541153 Method of screening a substance interfering in the association of DOCK2 and ELMO
7528575 Method and apparatus for correcting voltage of secondary battery, and method and apparatus for estimating state of charge of secondary battery
7514209 Diagnosis and prognosis of breast cancer patients

View more patents.

VAV3 results (if any) from reagent suppliers

Google CSE Logo
VAV3 antibody (ab21208) | Abcam
Goat polyclonal to VAV3. Vav proteins are members of the Dbl-family of GEFs ( Guanine Nucleotide Exchange Factors) for the Rho/Rac-family GTPases which ...
http://www.abcam.com/VAV3-antibody-ab21208.html...

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Vav3 Antibody #2398
Vav3 Antibody detects endogenous levels of total Vav3 protein. The antibody does not cross-react with endogenous levels of other Vav family members. ...
http://www.cellsignal.com/products/2398.html...

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VAV3 antibodies: Cancer > Signal transduction > G protein ...
VAV3 antibodies. ... VAV3 antibody. Flow Cyt, IP, WB, ICC/IF, IHC-P. Images. Rabbit polyclonal. Reacts with: Hu, Ms. ab52938 · VAV3 antibody [EP1130Y] ...
http://www.abcam.com/index.html?t=32881&pt=1&c=4300&ei=&mu=r...

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Vav Isoform Antibody Sampler Kit #5145
The three identified mammalian Vav proteins (Vav1, Vav2 and Vav3) differ in ... Vav2 and Vav3 are more ubiquitously expressed. Vav proteins contain the Dbl ...
http://www.cellsignal.com/products/5145.html...

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VAV3 peptide - phospho Y173 (phospho and non-phospho pair) (ab5747 ...
VAV3 peptide - phospho Y173 (phospho and non-phospho pair). Vav proteins are members of the Dbl-family of GEFs (Guanine Nucleotide Exchange Factors) for the
...
http://www.abcam.com/VAV3-peptide-phospho-Y173-phospho-and-n...

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Vav Antibody / Vav Antibodies
Vav3 (K-19) Antibody, sc-28474, goat IgG, internal (h), WB, IF, ELISA, m, r, h ... Vav3 shRNA Plasmid (m): sc-155095-SH. Vav3 shRNA (m) ...
http://www.scbt.com/table-vav.html...

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Vav Isoform Antibody Sampler Kit
teins (Vav1, Vav2 and Vav3) differ in their expression. Vav1 is expressed only in hematopoietic ... and the central sequence of human Vav3. Antibodies are ...
http://www.cellsignal.com/pdf/5145.pdf...

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