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MAD2L2


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Symbol:MAD2L2
Name(s):MAD2 mitotic arrest deficient-like 2 (yeast)
Type:protein-coding
Organism:Homo sapiens
Synonyms:MAD2B, REV7
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17268814 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17541814 Hepatocellular carcinoma-associated gene 2 interacts with MAD2L2.
17296730 Human Rev7 (hRev7)/MAD2B/MAD2L2 is an interaction partner for Elk-1 and hRev7 acts to promote Elk-1 phosphorylation by the c-Jun N-terminal protein kinase (JNK) MAP kinases.
12529368 purified human REV1 and REV7 proteins form a heterodimer in solution, which is stable through intensive purification steps.
17044027 Upregulated MAD2L2 expression is associated with colorectal tumors
17333263 Chromophobe renal cell carcinoma presented underexpression of MAD1, and MAD2L2.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDHomo sapiens DNA polymerase zeta catalytic subunit mRNA, complete cds.MAD2 homologhRev3 interacts with hRev7.-Pubmed
HPRDDNA polymerase zeta catalytic subunit.MAD2 homolog--Pubmed
HPRDDNA polymerase zeta catalytic subunit.MAD2 homolog--Pubmed
HPRDHLA-B associated transcript-2 isoform aMAD2 homolog--Pubmed
HPRDHLA-B associated transcript-2 isoform aMAD2 homolog--Pubmed
BINDADAM metallopeptidase domain 9 isoform 1 precursorMAD2 homologMAD2 beta interacts with MDC9.-Pubmed
BINDMAD2 homologMAD2 homologREV7 interacts with REV7 to form a homodimer.-Pubmed
BINDMAD2 homologMAD2 homologMAD2B interacts with MAD2B.-Pubmed
HPRDMAD2 homologREV1-like isoform 1--Pubmed
BINDMAD2 homologREV1-like isoform 1REV1 interacts with REV7.-Pubmed

Recent Publications on MAD2L2:

Pubmed Logo
MAD2B, a novel TCF4-binding protein, modulates TCF4-mediated epithelial-mesenchymal transdifferentiation.
T cell factor 4 (TCF4) interacts with beta-catenin in the WNT signaling...
26th September, 2009
Graduate Institute of Life Science, National Defense Medical Center, J Biol Chem. 2009 Jul 17;284(29):19613-22. Epub 2009 May 14.
DOI Direct Link
The mitotic arrest deficient protein MAD2B interacts with the small GTPase RAN throughout the cell cycle.
BACKGROUND: Previously, we identified the mitotic arrest deficient protein...
16th September, 2009
Department of Human Genetics, Radboud University Nijmegen Medical Centre, PLoS One. 2009 Sep 15;4(9):e7020.
DOI Direct Link
Changes in expression of cell-cycle-related genes in PC-3 prostate cancer cells caused by ovine uterine serpin.
The hormonal-regulated serpin, ovine uterine serpin (OvUS), also called...
17th June, 2009
Department of Animal Sciences, University of Florida, Gainesville, Florida J Cell Biochem. 2009 Aug 15;107(6):1182-8.
DOI Direct Link
Studying chromosome instability in the mouse.
Aneuploidy has long been recognized as one of the hallmarks of cancer. It...
17th December, 2008
Harvard Medical School, Department of Systems Biology, 200 Longwood Biochim Biophys Acta. 2008 Sep;1786(1):73-82. Epub 2008 Jul 26.
DOI Direct Link
When 2+2=5: the origins and fates of aneuploid and tetraploid cells.
Aneuploid cells are frequently observed in human tumors, suggesting that...
17th December, 2008
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Biochim Biophys Acta. 2008 Sep;1786(1):4-14. Epub 2008 Aug 7.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

MAD2L2 results (if any) from reagent suppliers

Google CSE Logo
Recommended Dilutions: Purity and Specificity: This is an affinity ...
Background Information: MAD2L2 is a component of the ... MAD2L2 was used at a 1: 500 dilution to detect human. MAD2L2 by western blot. ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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Mad2L2 antibodies: Cancer > Cell cycle > Cell division | Abcam
Mad2L2 antibodies. ... Mad2L2 antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab3630 · Mad2L2 antibody ...
http://www.abcam.com/index.html?t=2593&pt=1&c=4198&ei=&mu=ra...

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MAD2B (C-14) Antibody sc-27731
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, MAD2L2, 10459, 1p36.22, NM_006341 ...
http://www.scbt.com/datasheet-27731-mad2b-c-14-antibody.html...

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Mad2L2 proteins and peptides: Cancer > Cell cycle > Cell division ...
Mad2L2 proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab11254 · Mad2L2 peptide (3-14) ...
http://www.abcam.com/index.html?t=2593&pt=2&c=4198&ei=&mu=ra...

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Product Specification Sheet
MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been ... Affinity Purified Anti-Human MAD2L2 (Rabbit). #W09-000-364 ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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Abcam antibodies and reagents product map
... MAS1 antibodies (2) · MPHOSPH9 antibodies (1) · Mad2L1 antibodies (5) · Mad2L2 antibodies (1) · Mad2L2 proteins and peptides (1) · NEK2 antibodies (4)
...
http://www.abcam.com/index.html?pageconfig=productmap&cl=228...

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Kinases and Phosphatases-Rockland Immunochemicals
600-401-470 · Anti-Human MAD2L2 (Rabbit), 100ug, $245.00. 000-001-470 · Anti- Human MAD2L2 (Rabbit) CONTROL PEPTIDE for Catalog #600-401-470, 50ug, $75.00 ...
http://www.rockland-inc.com/ccc1142-kinases-and-phosphatases...

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