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CAMKK2
| Symbol: | CAMKK2 | | Name(s): | calcium/calmodulin-dependent protein kinase kinase 2, beta | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CAMKK, CAMKKB, KIAA0787, MGC15254 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16673375 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17197037 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17197037 |
a prominent association found between severity of panic- and agoraphobia symptoms and an exonic SNP (rs3817190) in the CaMKKb gene and a trend for association with an exonic SNP in P2RX7 (rs1718119) with severity scores in the panic- and agoraphobia scale |
| 16054096 |
Overexpression of CaMKKbeta in mammalian cells increases AMPK activity, whereas pharmacological inhibition of CaMKK, or downregulation of CaMKKbeta using RNA interference, almost completely abolishes AMPK activation |
| 16054095 |
There is a significant basal activity and phosphorylation of AMPK in LKB1-deficient cells that can be stimulated by Ca2+ ionophores, and studies using the CaMKK inhibitor STO-609 and isoform-specific siRNAs show that CaMKKbeta is required for this effect |
| 16880506 |
Endothelial cells possess two pathways to activate AMPK, one Ca2+/CaMKKbeta dependent and one AMP/LKB1 dependent. |
| 16247765 |
Increased expression of calcium/calmodulin-dependent protein kinase IIbeta in frontal cortex in schizophrenia and depression. |
Recent Publications on CAMKK2: |  |
Shedding light on the intricate puzzle of ghrelin's effects on appetite regulation.
Ghrelin, a hormone primarily produced by the stomach, has a wide range of... | 22nd September, 2009
| Endocrinology, William Harvey Research Institute, Barts and the London
| J Endocrinol. 2009 Aug;202(2):191-8. Epub 2009 Mar 20.
DOI Direct Link |
In vivo selection of kinase-responsive RNA elements controlling alternative splicing.
Alternative pre-mRNA splicing is often controlled by cell signals, for... | 21st August, 2009
| Department of Physiology, Faculty of Medicine, University of Manitoba,
| J Biol Chem. 2009 Jun 12;284(24):16191-201. Epub 2009 Apr 22.
DOI Direct Link |
BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV.
The Ca(2+)/calmodulin-activated kinases CaMKK2 and CaMKIV are highly... | 4th August, 2009
| Department of Pharmacology and Cancer Biology, Duke University Medical
| J Neurosci. 2009 Jul 15;29(28):8901-13.
DOI Direct Link |
Central AMPK contributes to sleep homeostasis in mice.
AMP-activated protein kinase (AMPK) is an energy-sensing molecular signal... | 21st July, 2009
| Department of Integrative Physiology, Institute of Health Biosciences, The
| Neuropharmacology. 2009 Sep;57(4):369-74. Epub 2009 Jul 15.
DOI Direct Link |
Inhibition of cervical cancer cell growth through activation of upstream kinases of AMP-activated protein kinase.
AMP-activated protein kinase (AMPK) is a critical energy-balancing sensor... | 26th June, 2009
| Department of Obstetrics and Gynaecology, University of Hong Kong, Hong
| Tumour Biol. 2009;30(2):80-5. Epub 2009 May 4.
DOI Direct Link |
→View more research publications. |
CAMKK2 results (if any) from reagent suppliers | 
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CAMKK2 antibodies: Signal Transduction > Protein Phosphorylation ...
CAMKK2 antibodies. ... Image Abreview Publication. ab70909 · CAMKK2 antibody - C -terminal. IHC-P, WB, ELISA. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=247025&pt=1&c=2125&ei=&mu=...
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Product Unavailable: CaMKK2 Kinase #7396
Purified recombinant full length human CaMKK2 (Met1-Leu541) kinase, supplied as a GST fusion protein.
http://www.cellsignal.com/products/7396.html...
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CAMKK2 Active (C7370) - Datasheet
brain, thymus, spleen, and testis.1 CAMKK2 undergoes intramolecular autophosphorylation ... Kinase Solution – Dilute the Active CAMKK2 (0.1 µg/µl)
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http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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Abgent - Phosphorylation Antibodies - Phosphorylation
AP7117b, CAMKK2 Antibody (C-term), WB, IHC, E, H. AP7117a, CAMKK2 Antibody (N- term), E, H. AP7118b, CAMKV Antibody (C-term K484), WB, E, H ...
http://www.abgent.com/products/category/protein_modification...
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CaMKKβ (L-19) Antibody sc-9629
Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab. 7(5): 377-388. PubMed Entry 보기. Jensen, T. E. et al. 2007. ...
http://www.scbt.com/ko/datasheet-9629-camkkbeta-l-19-antibod...
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Abgent Antibodies and Peptides
AP8168b, BRSK1 Antibody (C-term), H. AP7116a, CABC1 Antibody (N-term), H. AP7117a, CAMKK2 Antibody (N-term), H. AP7118a, CAMKV Antibody (N-term), H ...
http://www.abgent.com/docs/product_investigation...
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All MAPK Pathway | Abcam
CAMKK2 antibody - C-terminal. IHC-P, WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu. ab70908 · CAMKK2 antibody - N-terminal. IHC-P, WB, ELISA ...
http://www.abcam.com/index.html?c=2125...
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