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ADCY1


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Gene DB Home
Symbol:ADCY1
Name(s):adenylate cyclase 1 (brain)
Type:protein-coding
Organism:Homo sapiens
Synonyms:AC1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17586501 Fully differentiated human airway epithelial cells in culture are shown to express calcium-stimulated transmembrane adenylyl cyclase (tmAC) isoforms (types 1, 3, and 8) by reverse transcription polymerase chain reaction.
12743114 Tissue transglutaminase directly regulates adenylyl cyclase resulting in enhanced cAMP-response element-binding protein (CREB) activation.
16531006 These results suggest a possible role of APLP1 in regulation of alpha2A-adrenergic receptor trafficking.
15361543 Expression of sensitization of AC1 involves Galpha(s)-adenylyl cyclase interactions.
15133516 Transgenic mice overexpressing type-1 adenylyl cyclase in the forebrain show elevated long-term potentiation (LTP), increased memory for object recognition and slower rates of extinction for contextual memory.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAdenylate cyclase 1Homo sapiens adenylyl cyclase type II mRNA, complete cds.--Pubmed
HPRDbrain adenylate cyclase 1Adenylate cyclase 2--Pubmed

Recent Publications on ADCY1:

Pubmed Logo
Essential roles of dopamine D4 receptors and the type 1 adenylyl cyclase in photic control of cyclic AMP in photoreceptor cells.
Light and dopamine regulate many physiological functions in the vertebrate...
14th April, 2009
Department of Pharmacology, Emory University School of Medicine, Atlanta, J Neurochem. 2009 Apr;109(1):148-57. Epub 2009 Jan 22.
DOI Direct Link
Genetic analysis of posterior medial barrel subfield (PMBSF) size in somatosensory cortex (SI) in recombinant inbred strains of mice.
BACKGROUND: Quantitative trait locus (QTL) mapping is an important tool...
14th May, 2008
Department of Anatomy and Neurobiology, University of Tennessee Health BMC Neurosci. 2008 Jan 7;9:3.
DOI Direct Link
Reduced sinoatrial cAMP content plays a role in postnatal heart rate slowing in the rabbit.
1. Decreasing heart rate during development is known to be the result of...
9th August, 2007
Department of Physiology, Shanghai Jiao Tong University Medical School, Clin Exp Pharmacol Physiol. 2006 Aug;33(8):757-62.
DOI Direct Link
Role of the calcium modulated cyclases in the development of the retinal projections.
Transmembrane isoforms of adenylate cyclases (AC) integrate a wide variety...
7th March, 2007
INSERM, U616, IFR Neurosciences, Hopital Salpetriere, Paris, France. Eur J Neurosci. 2006 Dec;24(12):3401-14.
DOI Direct Link
Temporal coupling of cyclic AMP and Ca/calmodulin-stimulated adenylyl cyclase to the circadian clock in chick retinal photoreceptor cells.
cAMP signaling pathways play crucial roles in photoreceptor cells and...
11th January, 2007
Department of Pharmacology, Emory University School of Medicine, Atlanta, J Neurochem. 2006 Nov;99(4):1142-50. Epub 2006 Sep 18.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector

ADCY1 results (if any) from reagent suppliers

Google CSE Logo
A cyclase I (V-20) Antibody sc-586
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADCY1, 107, 7p13, NM_021116 · Q08828
...
http://www.scbt.com/datasheet-586-a-cyclase-i-v-20-antibody....

Thumbshot
Anti-Adenylate Cyclase 1 (AC-1) - FabGennix Inc. International ...
Alternate Nomenclature: ADCY1. The membrane-bound adenylyl cyclases (ACs) represent one of the major families of effector enzymes for G protein-coupled
...
http://www.fabgennix.com/prod_details.asp?myproduct=Anti-Ade...

Thumbshot
S153 SQ 22536 ≥98% (HPLC), solid
ADCY1(107), ADCY2(108), ADCY3(109), ADCY4(196883), ADCY5(111), ADCY6(112), ADCY7 (113), ADCY8(114), ADCY9(115). rat ... Adora1(29290), Adora2a(25369) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=S153...

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