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LASS1


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Symbol:LASS1
Name(s):LAG1 homolog, ceramide synthase 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:CerS1, LAG1, MGC90349, UOG1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12105227 regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cel
15317812 LAG1 and C18-ceramide have roles in the regulation of growth of HNSCC

Recent Publications on LASS1:

Pubmed Logo
The longevity assurance homologue of yeast lag1 (Lass) gene family (review).
The Lass gene family contains a group of highly conserved genes that are...
21st April, 2009
Department of Internal Medicine I, Johannes Gutenberg University, 55101 Int J Mol Med. 2009 Feb;23(2):135-40.
Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2.
Synthesis of dihydroceramide is catalyzed by a family of (dihydro)ceramide...
9th September, 2008
Institute of Physiological Chemistry, University of Bonn, 53115 Bonn, Histochem Cell Biol. 2008 Feb;129(2):233-41. Epub 2007 Sep 28.
DOI Direct Link
Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1.
Yeast LAG1 was one of the first longevity genes found. Subsequent analysis...
1st March, 2008
Institute for Behavioral Genetics, University of Colorado at Boulder, Age (Dordr). 2008 Mar;30(1):43-52. Epub 2008 Feb 16.
DOI Direct Link
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.
In this study, quantitative isobologram studies showed that treatment with...
10th November, 2007
Department of Biochemistry and Molecular Biology, Medical University of Mol Cancer Ther. 2007 Feb;6(2):712-22.
DOI Direct Link
(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1.
Resistance to chemotherapeutic drugs often limits their clinical efficacy....
17th October, 2007
Division of Biological Sciences, 303 Tucker Hall, University of Missouri, Mol Cancer Res. 2007 Aug;5(8):801-12.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7273614 Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof

LASS1 results (if any) from reagent suppliers

Google CSE Logo
LASS1 antibody (ab56992) | Abcam
Mouse monoclonal to LASS1. LASS1 may be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells it is ...
http://www.abcam.com/LASS1-antibody-ab56992.html...

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Lass1 (Cross reacts with GDF1) Blocking Peptide
12 Aug 2008 ... For use with Lass1 polyclonal antibodies (Cat. No. X2084P & X2310P). ... Example : 10 µl or 10 µg of Exalpha's rabbit anti-Lass1 (Cat. No. ...
http://exalpha.com/pdfs/X2294B.pdf...

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LASS Antibody / LASS Antibodies
LASS1 (C-14) Antibody, sc-65096, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h. LASS1 (D-15) Antibody, sc-65097, goat IgG, Internal (h), WB, IF, ELISA ...
http://www.scbt.com/ko/table-lass.html...

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X2083P - Exalpha Biologicals, Inc.
Lass1 may be either a bona fide (dihydro)ceramide synthase or a ... Located in the endoplasmic reticulum membrane; LAss1 is a multi-pass membrane protein. ...
http://exalpha.com/ProductPage.php?SearchTerm=X2083P&menuval...

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LASS Antibody / LASS Antibodies
LASS1 (C-14) 抗体, sc-65096, goat IgG, C-terminus (h), WB, IF, ELISA, m, r, h. LASS1 (D-15) 抗体, sc-65097, goat IgG, Internal (h), WB, IF, ELISA, m, r, h ...
http://www.scbt.com/ja/table-lass.html...

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LASS6 Antibody longetivity, sphingolipids, ceramide synthesis
Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer ...
http://www.prosci-inc.com/shop/catalog1/LASS6-Antibody-p-679...

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LASS1 (I-16) Antibody sc-65098
LASS1 shRNA (h) Lentiviral Particles, sc-62543-V, 200 µl, $595. LASS1 shRNA (m) Lentiviral Particles, sc-62544-V, 200 µl ...
http://www.scbt.com/ko/datasheet-65098-lass1-i-16-antibody.h...

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