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JARID1B
| Symbol: | JARID1B | | Name(s): | jumonji, AT rich interactive domain 1B | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | FLJ10538, FLJ12459, FLJ12491, FLJ16281, FLJ23670, KDM5B, PLU-1, PUT1, RBBP2H1A | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17709396 |
Results identify the target genes regulated by PLU-1/JARID1B, and show that cells overexpressing PLU-1/JARID1B have an impaired G(2)/M checkpoint. |
| 17973255 |
data support an anti-tumorigenic role of RBP2-H1/JARID1B in melanocytic cells. |
| 18048344 |
JARID1B was identified as a demethylase capable of removing three methyl groups from histone H3 lysine 4 and up-regulated in prostate cancer. |
| 17363312 |
PLU-1-mediated H3K4 demethylase activity plays an important role in the proliferative capacity of breast cancer cells through repression of tumor suppressor genes. |
| 17373667 |
Results show that both JARID1B and HDAC4 expressed in breast cancers. |
| 12657635 |
BF-1 and PAX9 interact with PLU-1 via a novel conserved sequence motif (Ala-X-Ala-Ala-X-Val-Pro-X4-Val-Pro-X8-Pro, termed the VP motif) |
| 12237901 |
results suggest that the PLU-1 protein may belong to the class of testis/cancer antigens |
Recent Publications on JARID1B: |  |
1H, 13C, 15N backbone and side-chain resonance assignments of the Bright/ARID domain from the human histone demethylase JARID1B.
We report backbone and side-chain resonance assignments of the Bright/ARID... | 29th October, 2009
| Key Laboratory of Optical and Magnetic Resonance Spectroscopy, East China
| Biomol NMR Assign. 2009 Jun;3(1):85-7. Epub 2009 Feb 24.
DOI Direct Link |
Regulation of the Histone Demethylase JMJD1A by HIF-1{alpha} Enhances Hypoxic Gene Expression and Tumor Growth.
The hypoxia-inducible transcription factors (HIFs) directly and indirectly... | 28th October, 2009
| Division of Radiation and Cancer Biology, Department of Radiation
| Mol Cell Biol. 2009 Oct 26.
DOI Direct Link |
The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor.
JARID1B (jumonji AT rich interactive domain 1B) is a large nuclear protein... | 20th June, 2009
| Institute of Immunology, Zhejiang University, Hangzhou 210058, China.
| BMB Rep. 2009 Mar 31;42(3):154-9.
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The ZNF217 oncogene is a candidate organizer of repressive histone modifiers.
The zinc finger protein 217 (ZNF217) is an important oncogene based on the... | 18th June, 2009
| Department of Medicine (Hematology/Oncology), Mount Sinai School of
| Epigenetics. 2009 Feb;4(2):100-6. Epub 2009 Feb 23.
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The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation.
The histone demethylase lysine demethylase 5b (KDM5b) specifically... | 10th September, 2008
| Stem Cell and Cancer Institute, MDCL Rm. 5030, Faculty of Health Sciences,
| Mol Cell Biol. 2008 Sep;28(17):5312-27. Epub 2008 Jun 30.
DOI Direct Link |
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