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WASF3


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Symbol:WASF3
Name(s):WAS protein family, member 3
Type:protein-coding
Organism:Homo sapiens
Synonyms:Brush-1, KIAA0900, SCAR3, WAVE3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17623672 the activation of WAVE3 to promote actin remodeling is enhanced by the c-Abl-mediated tyrosine phosphorylation of WAVE3.
15670045 during megakaryocytic differentiation, platelets expressed WAVE-1 and WAVE-2, whereas WAVE-3 expression was hardly to be detected. WAVE-3 expression was not changed by the differentiation
15280206 the 3 WAVE isoforms exhibit common and distinct features and may potentially be involved in the regulation of actin cytoskeleton in platelets
12185600 patient with ganglioneuroblastoma carries an apparently balanced t(1:13)(q21:q12) reciprocal translocation. Positional cloning of the translocation breakpoint on chromosome 13 resulted in the mapping of the breakpoint between coding exon 2 and 3 of WAVE3
15752430 all three Scar/WAVE isoforms behave similarly and are likely to participate in the same kinds of protein complexes that regulate actin assembly
15826941 WAVE3-mediated migration in MDA-MB-231 cells via lamellipodia formation is activated downstream of PI3K and induced by PDGF
15907837 The WAVE3 is a member of the WASP/WAVE family of proteins, which play a critical role in the regulation of actin polymerization, cytoskeleton organization, and cell motility.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActin related protein 3WAS protein family, member 3--Pubmed
HPRDARP3 actin-related protein 3 homologWiskott-Aldrich syndrome protein family member 3--Pubmed

Recent Publications on WASF3:

Pubmed Logo
Detection of novel copy number variants in uterine leiomyomas using high-resolution SNP arrays.
Uterine leiomyomas (ULs) are benign monoclonal tumors originating from...
23rd October, 2009
Department of Obstetrics and Gynecology, Baylor College of Medicine, Mol Hum Reprod. 2009 Sep;15(9):563-8. Epub 2009 Jun 30.
DOI Direct Link
The actin polymerization regulator WAVE2 is required for early bone marrow repopulation by hematopoietic stem cells.
The Rho GTPase family members play essential roles in hematopoiesis. Of...
25th July, 2009
Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Stem Cells. 2009 May;27(5):1120-9.
DOI Direct Link
c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
The activity of the Wiskott-Aldrich syndrome-related WAVE3 protein is...
2nd November, 2007
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New J Biol Chem. 2007 Sep 7;282(36):26257-65. Epub 2007 Jul 9.
DOI Direct Link
Down-regulation of WAVE3, a metastasis promoter gene, inhibits invasion and metastasis of breast cancer cells.
The expression of WAVE3, an actin-cytoskeleton and reorganization protein,...
18th July, 2007
Roswell Park Cancer Institute, Department of Cancer Genetics, Elm and Am J Pathol. 2007 Jun;170(6):2112-21.
Differentially expressed genes between high-risk human papillomavirus types in human cervical cancer cells.
Cervical carcinoma (CC) is one of the most common cancers among women...
16th May, 2007
Laboratory of Oncogenomics, Oncology Research Unit, Oncology Hospital, Int J Gynecol Cancer. 2007 Mar-Apr;17(2):484-91. Epub 2007 Feb 14.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7442390 Method for enhancing engraftment of cells using mesenchymal progenitor cells
7217807 Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
7049072 Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state

WASF3 results (if any) from reagent suppliers

Google CSE Logo
WASF3 antibodies: Cancer > Signal transduction > G protein ...
WASF3 antibodies. ... WASF3 antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. Terms and conditions · Legal · Privacy policy ...
http://www.abcam.com/index.html?t=259217&pt=1&c=4300&ei=&mu=...

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ORDERING INFORMATION
Human WASF3/WAVE3 is 502 amino acids (aa) in length. It contains one ... This antibody detects endogenous human/mouse WASF3/WAVE3 in Western blot with an ...
http://www.rndsystems.com/pdf/AF5515.pdf...

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WAVE3 (N-16) Antibody sc-10395
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, WASF3, 10810, 13q12.13, NM_006646 ...
http://www.scbt.com/datasheet-10395-wave3-n-16-antibody.html...

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June 09 NPR non-priced.indd
WASF3/WAVE3. Human/Mouse. Goat IgG. AF5515. 100 µg. ZIC3. Human/Mouse. Sheep IgG . AF5310. 100 µg. Proprotein Convertase 9: Recombinant Protein & ELISA Kit ...
http://www.rndsystems.com/DAM_public/6399.pdf...

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WAVE3 (N-16) Antibody sc-10395
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, WASF3, 10810, 13q12.13, NM_006646 ...
http://www.scbt.com/ja/datasheet-10395-wave3-n-16-antibody.h...

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Browse By Molecule < W > - R&D Systems
WASF3/WAVE3 ...
http://www.rndsystems.com/molecule_letter.aspx?l=W...

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Abcam antibodies and reagents product map
... Vinculin proteins and peptides (1) · WASF3 antibodies (2) · Zyxin antibodies (6) · Zyxin proteins and peptides (1) · alpha 1 Spectrin antibodies (2) ...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...

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