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ADAM28


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Symbol:ADAM28
Name(s):ADAM metallopeptidase domain 28
Type:protein-coding
Organism:Homo sapiens
Synonyms:ADAM23, MDC-Lm, MDC-Ls, MDCL, eMDCII
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17597069 ADAM28s promotes PSGL-1/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with PSGL-1
17047053 ADAM28 is overexpressed in an activated form in breast carcinoma cells and suggest ADAM28 is involved in cell proliferation through enhanced bioavailability of IGF-I released from the IGF-I/IGFBP-3 complex by IGFBP-3 cleavage in breast carcinomas.
12777399 ADAM8, ADAM15, and ADAM28, but not ADAM17, catalyzed ectodomain shedding of CD23, the low affinity IgE receptor.
16052521 data demonstrate for the first time that ADAM28 is overexpressed and activated in human non-small cell lung carcinomas, and suggest the possibility that ADAM28 plays a role in cell proliferation and progression of the human lung carcinomas

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDIntegrin alpha 4a disintegrin and metalloproteinase domain 28 isoform 2 preproprotein--Pubmed

Recent Publications on ADAM28:

Pubmed Logo
ADAM28 as a target for human cancers.
ADAM28 is a member of the ADAM (a disintegrin and metalloproteinase) gene...
23rd October, 2009
Department of Pathology, School of Medicine, Keio University, Tokyo, Curr Pharm Des. 2009;15(20):2349-58.
All-trans retinoic acid-induced ADAM28 degrades proteoglycans in human chondrocytes.
In order to elucidate the mechanism of cartilage degradation in...
28th July, 2009
Pharmacology Research Laboratories II, Takeda Pharmaceutical Company Ltd, Biochem Biophys Res Commun. 2009 Aug 21;386(2):294-9. Epub 2009 Jun 13.
DOI Direct Link
Influence of ADAM28 on biological characteristics of human dental follicle cells.
OBJECTIVES: The aim of this study was to investigate the effects of a...
8th July, 2009
Institute of Stomatology, General Hospital of Chinese People's Liberation Arch Oral Biol. 2009 Sep;54(9):835-45. Epub 2009 Jul 5.
DOI Direct Link
Hepatic expression of A disintegrin and metalloproteinase (ADAM) and ADAMs with thrombospondin motives (ADAM-TS) enzymes in patients with chronic liver diseases.
BACKGROUND/AIMS: ADAMs (A Disintegrin And Metalloprotease) are...
10th January, 2009
Institute of Clinical Chemistry, Hannover Medical School, 30623 Hannover, J Hepatol. 2008 Aug;49(2):243-50. Epub 2008 Apr 24.
DOI Direct Link
Essential role of ADAM28 in regulating the proliferation and differentiation of human dental papilla mesenchymal cells (hDPMCs).
Dental papilla mesenchymal cells (DPMCs) have been supposed to possess the...
17th December, 2008
Research and Development Center for Tissue Engineering, Fourth Military Histochem Cell Biol. 2008 Nov;130(5):1015-25. Epub 2008 Aug 9.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7491724 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
7485468 Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases

View more patents.

ADAM28 results (if any) from reagent suppliers

Google CSE Logo
ADAM28 antibody - Aminoterminal end (ab40135) | Abcam
Rabbit polyclonal to ADAM28 - Aminoterminal end. ADAM28, also known as eMDCII, MDC-Ls and TECADAM, was first described in lymphocytes, also in Thymic ...
http://www.abcam.com/ADAM28-antibody-Aminoterminal-end-ab401...

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ADAM Antibody / ADAM Antibodies
ADAM28 (L-16) Antibody, sc-26012, goat IgG, internal (h), WB, IF, ELISA, human ... ADAM28 (A-20) Antibody, sc-26011, goat IgG, Internal (h), discontinued ...
http://www.scbt.com/table-adam.html...

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ADAM28 peptide (Aminoterminal end) (ab41223) | Abcam
ADAM28, also known as eMDCII, MDC-Ls and TECADAM, was first described in lymphocytes, also in Thymic Endothelial Cells (TECADAM), as well as in the ep...
http://www.abcam.com/ADAM28-peptide-Aminoterminal-end-ab4122...

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ADAM28 (A-20) Antibody sc-26011
goat polyclonal IgG, 200µg/ml; epitope mapping within an internal region of ADAM28 of human origin; recommended for detection of ADAM28 of human origin by
...
http://www.scbt.com/ko/datasheet-26011-adam28-a-20-antibody....

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ADAM28 antibodies: Cell Biology > Proteolysis / Ubiquitin ...
ADAM28 antibodies. ... ADAM28 antibody - Aminoterminal end. WB. Rabbit polyclonal ... ADAM28 antibody - Cytoplasmic domain. WB. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=135269&pt=1&c=4347&ei=&mu=...

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ADAM28 siRNA (h) sc-105041
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: ADAM28 ...
http://www.scbt.com/ko/datasheet-105041-adam28-sirna-h.html...

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All ADAM Protein Family | Abcam
ADAM28 antibody - Aminoterminal end. WB, ICC/IF. Customer Abreviews: 4 stars ( out of 5). Rabbit polyclonal. Reacts with: Hu. Back to top. A B - Z ...
http://www.abcam.com/index.html?c=3657...

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