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GADD45G
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15353598 |
Inhibition of GADD45alpha and gamma in cancer cells by small interfering RNA abrogates apoptosis induction by the inhibitor of NF-kappaB |
| 12716909 |
results suggest that CRIF1 is a novel nuclear protein that interacts with Gadd45 and may play a role in negative regulation of cell cycle progression and cell growth |
| 16166418 |
Results show that GADD45G can act as a functional new-age tumor suppressor but being frequently inactivated epigenetically in multiple tumors. |
| 11889197 |
a powerful growth suppressor controlling pituitary cell proliferation and the first identified gene whose expression is lost in the majority of human pituitary tumors. |
| 14672412 |
Data show that GADD45 gamma mRNA expression is down-regulated in hepatocellular carcinoma, and that GADD45 gamma causes cell cycle arrest at G2/M transition when transfected into Hep-G2 cells. |
| 17178890 |
Establish MDA-7/IL-24 and GADD45alpha and GADD45gamma as critical mediators of apoptosis and growth arrest in response to NSAIDs in cancer cells. |
| 15062559 |
GADD45g induction by androgens requires new protein synthesis; overexpression of GADD45g inhibited cell growth and caused morphological changes in prostate cell lines, arguing that GADD45g is involved in differentiation induced by androgens |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Cyclin B1 | growth arrest and DNA-damage-inducible, gamma | - | - | Pubmed |
| HPRD | cyclin B1 | GADD45 gamma | - | - | Pubmed |
| BIND | cyclin B1 | growth arrest and DNA-damage-inducible, gamma | Cyclin B1 interacts with Gadd45g. This interaction was modeled on a demonstrated interaction between human Cyclin B1 and Gadd45g from an unspecified species. | - | Pubmed |
| BIND | - | growth arrest and DNA-damage-inducible, gamma | Cdk1 interacts with Gadd45g. This interaction was modeled on a demonstrated interaction between human Cdk1 and Gadd45g from an unspecified species. | - | Pubmed |
| HPRD | cell division cycle 2 protein isoform 1 | growth arrest and DNA-damage-inducible, gamma | - | - | Pubmed |
| HPRD | cell division cycle 2 protein isoform 1 | growth arrest and DNA-damage-inducible, gamma | - | - | Pubmed |
| HPRD | Cyclin dependent kinase inhibitor 1A | growth arrest and DNA-damage-inducible, gamma | - | - | Pubmed |
| HPRD | cyclin-dependent kinase inhibitor 1A | GADD45 gamma | - | - | Pubmed |
| HPRD | growth arrest and DNA-damage-inducible, alpha | growth arrest and DNA-damage-inducible, gamma | - | - | Pubmed |
| HPRD | growth arrest and DNA-damage-inducible, alpha | growth arrest and DNA-damage-inducible, gamma | - | - | Pubmed |
Recent Publications on GADD45G: |  |
Age-associated changes in cardiac gene expression after preconditioning.
BACKGROUND: Cardiac protection afforded by ischemic preconditioning (IPC)... | 28th October, 2009
| Department of Anesthesiology, Stony Brook University School of Medicine,
| Anesthesiology. 2009 Nov;111(5):1052-64.
DOI Direct Link |
Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli.
The GADD45 family of proteins consists of three small proteins, GADD45A,... | 17th October, 2009
| Fels Institute for Cancer Research and Molecular Biology, Temple
| J Cell Biochem. 2009 Oct 15.
DOI Direct Link |
Gene expression studies reveal that DNA damage, vascular perturbation, and inflammation contribute to the pathogenesis of carbonyl sulfide neurotoxicity.
Carbonyl sulfide (COS) is an odorless gas that produces highly... | 4th September, 2009
| Charles River Laboratories, Pathology Associates, Durham, NC 27703, USA.
| Toxicol Pathol. 2009;37(4):502-11. Epub 2009 Apr 24.
DOI Direct Link |
Gadd45b and Gadd45g are important for anti-tumor immune responses.
An effective Th1 type cell-mediated immune response against cancer cells... | 19th August, 2009
| Department of Immunology, University of Pittsburgh School of Medicine,
| Eur J Immunol. 2009 Aug 17;39(11):3010-3018.
DOI Direct Link |
Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus.
In rodents, the uterus of a mature female undergoes changes during the... | 8th August, 2009
| Oncology and Molecular Endocrinology Research Center, CHUL Research
| Mol Reprod Dev. 2009 Mar;76(3):278-88.
DOI Direct Link |
→View more research publications. |
GADD45G results (if any) from reagent suppliers | 
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GADD45G antibody (ab56802) | Abcam
Mouse monoclonal to GADD45G. This protein is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions ...
http://www.abcam.com/GADD45G-antibody-ab56802.html...
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ZBRK1 Antibody Zinc finger protein 350
(Catalog No. 1288). BRCA1 Antibody (Catalog No. XW-7058). GADD45G Antibody ( Catalog No. XW-7211). ZBRK1 Peptide (Catalog No. 4817P). ...
http://www.prosci-inc.com/shop/catalog1/ZBRK1-Antibody-p-676...
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GADD45G antibodies: Chromatin and Nuclear Signaling > DNA / RNA ...
GADD45G antibodies. ... GADD45G antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication ...
http://www.abcam.com/index.html?t=160085&pt=1&c=889&ei=&mu=r...
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Abgent - Phosphorylation Antibodies - Phosphorylation
AT2145aNEW, GADD45A monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AT2146a NEW, GADD45G monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/protein_modification...
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GADD45G proteins and peptides: Cell Biology > Apoptosis ...
GADD45G proteins and peptides. ... Applications (see key) & Reactivity (see key) . Image Abreview Publication. ab40661 · GADD45G protein (His tag). SDS-PAGE ...
http://www.abcam.com/index.html?t=160085&pt=2&c=298&ei=&mu=r...
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Panorama® Antibody Array - Signal Transduction
GADD45G. growth arrest and DNA-damage-inducible. 10912 · GATA3. GATA binding protein 3. 2625 · GCLC. glutamate-cysteine ligase, catalytic subunit ...
http://www.sigmaaldrich.com/life-science/cell-biology/protei...
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GADD 45γ (C-16) Antibody sc-8778
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, GADD45G, 10912, 9q22.2, NM_006705 ...
http://www.scbt.com/ko/datasheet-8778-gadd-45gamma-c-16-anti...
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