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DBF4
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17768177 |
There is the differential regulation of a novel gene, namely ASK/Dbf4, in melanoma and suggest that up-regulation of ASK/Dbf4 is a novel molecular determinant with prognostic relevance that confers a proliferative advantage in cutaneous melanoma. |
| 12535533 |
Results demonstrate a DNA damage checkpoint that targets Cdc7/Dbf4 protein kinase. |
| 12015319 |
results suggest that E2F regulates the ASK promoter through an atypical mode of recognition of the target site |
| 16899510 |
Taken together, these results indicate that Cdc7/Dbf4 phosphorylation of MCM2 is essential for the initiation of DNA replication in mammalian cells. |
| 17276990 |
Overexpression of Dbf4 abrogates the S checkpoint response to ultraviolet radiation but not ionizing radiation. |
| 16826239 |
Cdc7-Dbf4 kinase efficiently phosphorylates p150. |
| 12420215 |
The HuDbf4 gene has of 12 exons over a 33-kb region. The MluI cell-cycle box is needed for core promoter activation. The Sp1 upregulator & HES-1 repressor coordinately determine promoter efficiency. Transcription initiations occur at -220, -235 and -245. |
Recent Publications on DBF4: |  |
Budding Yeast Dbf4 Sequences Required for Cdc7 Kinase Activation and Identification of a Functional Relationship Between the Dbf4 and Rev1 BRCT Domains.
Cdc7-Dbf4 is a two-subunit kinase required for initiating DNA replication.... | 14th October, 2009
| Van Andel Research Institute.
| Genetics. 2009 Oct 12.
DOI Direct Link |
Cdc7 kinase - A new target for drug development.
The cell division cycle 7 (Cdc7) is a serine threonine kinase that is of... | 10th October, 2009
| Cancer Therapy and Research Center,University of Texas Health Science
| Eur J Cancer. 2009 Oct 6.
DOI Direct Link |
Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.
BACKGROUND : Nitrogen-containing bisphosphonates are the elected drugs for... | 12th September, 2009
| Department of Biomedical Sciences and Technologies, University of Udine,
| Genome Biol. 2009;10(9):R93. Epub 2009 Sep 10.
DOI Direct Link |
Crystallization and preliminary X-ray diffraction analysis of motif N from Saccharomyces cerevisiae Dbf4.
The Cdc7-Dbf4 complex plays an instrumental role in the initiation of DNA... | 3rd September, 2009
| Department of Biochemistry and Biomedical Sciences, McMaster University,
| Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Sep 1;65(Pt
DOI Direct Link |
Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.
The Dbf4-Cdc7 kinase (DDK) is required for the activation of the origins... | 21st August, 2009
| Department of Biological Sciences, Vanderbilt University, Nashville,
| J Biol Chem. 2009 Oct 16;284(42):28823-31. Epub 2009 Aug 18.
DOI Direct Link |
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