BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

CBX1


Suggest Content
Advertise Here
Gene DB Home
Symbol:CBX1
Name(s):chromobox homolog 1 (HP1 beta homolog Drosophila )
Type:protein-coding
Organism:Homo sapiens
Synonyms:CBX, HP1-BETA, HP1Hs-beta, M31, MOD1
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17575412 Overexpression of HP1-BETA in eye imaginal discs caused abnormally patterned eyes, with reduced numbers of ommatidia.
11959914 Isoform-specific interaction of HP1 with human TAFII130.
14585993 cells are exquisitely sensitive to the amount of HP1(Hsalpha) or HP1(Hsbeta) present, as their overexpression influences telomere stability, population doubling time, radioresistance, and tumorigenicity
12054505 Gene regulation by human orthologs of Drosophila heterochromatin protein 1.
16615912 HP1 binding as analyzed through the crystal structure of the HP1-EMSY complex
15899859 HP1beta recruits endogenous HP1alpha to the chromatin and this induces heterochromatin formation and enhanced histone lysine methylation.
12560555 the chromodomain and the chromoshadow domain of HP1 are both required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin
16547356 analysis of methylation-independent binding to histone H3 and cell cycle-dependent incorporation of HP1beta into heterochromatin

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDDNA-methyltransferase 1chromobox homolog 1--Pubmed
HPRDDNA-methyltransferase 1chromobox homolog 1--Pubmed
HPRDDNA cytosine methyltransferase 3 alpha isoform bchromobox homolog 1--Pubmed
HPRDDNA cytosine methyltransferase 3 alpha isoform bchromobox homolog 1--Pubmed
BIND-chromobox homolog 1DNMT3B interacts with HP1-beta. This interaction was modeled on a demonstrated interaction between mouse Dnmt3b1 and human HP1-beta.-Pubmed
HPRDDNA cytosine-5 methyltransferase 3 beta isoform 1chromobox homolog 1--Pubmed
HPRDDNA cytosine-5 methyltransferase 3 beta isoform 1chromobox homolog 1--Pubmed
BINDantigen identified by monoclonal antibody Ki-67chromobox homolog 1pKi-67 interacts with the CS domain of HP1 protein via its C-terminus. This interaction was modeled on a demonstrated interaction between pKi-67 from human and HP1-beta from mouse.-Pubmed
HPRDPIM1chromobox homolog 1--Pubmed
HPRDpim-1 oncogeneHP1 beta--Pubmed

Patents:

Patents logo
US Patent No.Title
6992502 Configurable electronic circuit, in particular one dedicated to arithmetic calculations
4949373 Host load balancing
4942602 Coordinated transfer of voice and information through a network of digital switches

CBX1 results (if any) from reagent suppliers

Google CSE Logo
CBX1 / HP1 beta antibody (ab10478) datasheet | Abcam
Rabbit polyclonal to CBX1 / HP1 beta . Heterochromatin protein-1 (HP1) is localized at heterochromatin sites, where it mediates gene silencing.
http://www.abcam.com/index.html?datasheet=10478...

Thumbshot
Cbx1 chromobox homolog 1 (Drosophila HP1 beta)
Cbx1; CBX; CBX-RS2; CBX1; E430007M08RIK; HP1B; M31; MOD1. Other Designations. chromobox homolog 1. Refseq ID(s). NM_007622; XM_990275; XM_990301; XM_990359
...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

Thumbshot
HP1-beta Antibody
Anti-HP1? antibody; Anti-CBX1 antibody; Anti-MOD1 antibody; Anti-HP1hs-beta ... CBX1, Chromobox homolog 1; HP1Hs-beta, Heterochromatin protein 1 beta; MOD1, ...
https://www.bethyl.com/product/pdf/A300-019A.pdf...

Thumbshot
CBX1 chromobox homolog 1 (HP1 beta homolog Drosophila )
CBX1; CBX; HP1-BETA; HP1HS-BETA; M31; MOD1. Other Designations. heterochromatin protein p25 beta. Refseq ID(s). NM_006807. Accession No.(s) ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

Thumbshot
SUV420H1 antibody, SUV420H1 (suppressor of variegation 4-20 ...
Subunit: Interacts with HP1 proteins CBX1, CBX3 and CBX5. ... CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity) ...
http://www.genwaybio.com/product_info.php?products_id=44749&...

Thumbshot
HP1β (MAC353) Antibody sc-56704
Number. Human, CBX1, 10951, 17q21.32, NM_006807 · P83916 · 604511. Mouse, Cbx1, 12412, 11 D, P83917, N/A. Ordering Information ...
http://www.scbt.com/datasheet-56704-hp1beta-mac353-antibody....

Thumbshot
HP1-beta Antibody Bethyl Laboratories
Alternate Names, CBX1, Chromobox homolog 1; HP1Hs-beta, Heterochromatin protein 1 beta; MOD1, Modifier 1 protein; Heterochromatin protein p25; M31. ...
https://www.bethyl.com/go/?product/A300-019A/TreeKey=3281b58...

Thumbshot
Antibodies to Transcription Regulators
Cbx1(12412), human, mouse, rat, IF (i), IP, WB. H9912, Anti-hSNF5/INI1 antibody produced in rabbit, affinity isolated antibody, human ... SMARCB1(6598) ...
http://www.sigmaaldrich.com/catalog/search/TablePage/1383597...

Thumbshot
HP1β siRNA (m) sc-35588
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Cbx1, 12412, 11 D, P83917 ...
http://www.scbt.com/datasheet-35588-hp1beta-sirna-m.html...

Thumbshot
SI11100 MISSION siRNA Human Gene Family Panels Nucleic Acid ...
... BRCTD1(345499), BRD4(23476), BRD7(29117), BRD9(65980), BRIP1(83990), C21orf55(54943), CBX1(10951), CDC45L(8318), CDC6(990), CDK2AP1(8099), CENPA(1058
), ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

Thumbshot

Search Bioportfolio and other Life Science Sites for CBX1
This page has been viewed 57 times
Recent Search Terms used to find this page: Heterochromatin protein 1 homolog beta | hp1 beta cbx1 dna damage | .

Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

  Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2008 - BioPortfolio Limited.