BioPortfolio - YWHAQ - tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

YWHAQ

Symbol:

YWHAQ

Name(s):

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

14-3-3, 1C5, HS1

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

17973628

14-3-3 proteins could play a role in consolidating and strengthening the effects of phosphorylation on TPH2 and that they may be important for the regulation of serotonin function in the nervous system

17913709

PKA-phosphorylated NoxA1 is a new binding partner of 14-3-3 protein; this forms the basis of a novel mechanism regulating the formation of ROS by Nox1 and, potentially, other NoxA1-regulated Nox family members

18089831

Significant autoantibody reactivity against 14-3-3 theta was also observed in a set consisting of 18 prediagnostic lung cancer sera.

17617058

AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases.

17389761

ZNF198-FGFR1 activated prosurvival signaling pathways, resulting in elevated phosphorylation of FOXO3a. The phosphorylated residues subsequently sequestered the proapoptotic FOXO3a and BAD to 14-3-3 to prevent apoptosis

12535517

Data show that the Yes-associated protein (YAP) associates with 14-3-3 in an Akt-dependent manner.

16516142

In summary, our results show a direct interaction between CPAP and 14-3-3, and this interaction appears to be phosphorylation and cell cycle dependent.

16176975

COPI and 14-3-3 specifically bind to the GB1 RSR sequence and that COPI is involved in its intracellular retention

17369524

Regulation of AS160 and interaction with 14-3-3 in skeletal muscle are influenced by resistance exercise and insulin but do not fully explain the effect of resistance exercise on whole-body insulin action.

15930726

In transgenic mice with cardiac specific overexpression of dominant negative 14-3-3 protein, 14-3-3 negatively regulates cardiac hypertrophy and fibrosis, possibly through controlling expression of protein kinase C beta 2 in the diabetic myocardium.

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