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TOPBP1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16930991 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18006695 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17887956 |
human TopBP1 is involved in the formation of the initiation complex of replication in human cells and is required for the recruitment of Cdc45 to origins of DNA replication |
| 17913746 |
Interaction between SPBP and TopBP1 was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1. |
| 17765870 |
Together, these results suggested that TopBP1 might be a mediator of DNA damage signaling from NBS1 to ATR and promote homologous recombination repair. |
| 15961388 |
TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression |
| 12941802 |
hRad9/hHus1/hRad1 complex acts as a checkpoint sensor during S phase by rapidly localizing to sites of DNA damage and transducing checkpoint responses by facilitating proper localization of downstream checkpoint proteins, including TopBP1. |
| 16984230 |
A study evaluating several chromatin modification domains encoded by TopBP1, and the implications of these findings are discussed in the context of the DNA damage response and the understanding of TopBP1 function is presented. |
| 17448016 |
This report demonstrates aberrant expression of the TopBP1 protein in breast carcinoma. We propose TOPBP1 as a breast cancer susceptibility gene. |
| 12773567 |
TopBP1 is regulated by PML by association and stabilization of the protein in response to IR-induced DNA damage | →View more information from publications. |
Recent Publications on TOPBP1: |  |
Activation of ATR and related PIKKs.
The DNA damage response kinase ATR is an essential regulator of genome... | 4th November, 2008
| Department of Biochemistry, Vanderbilt University School of Medicine,
| Cell Cycle. 2008 Sep 15;7(18):2809-12. Epub 2008 Sep 30.
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The basic cleft of RPA70N binds multiple checkpoint proteins including RAD9 to regulate ATR signaling.
ATR kinase activation requires the recruitment of the ATR-ATRIP and... | 22nd October, 2008
| Department of Biochemistry and Center for Structural Biology, Vanderbilt
| Mol Cell Biol. 2008 Oct 20.
DOI Direct Link |
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.
The Myc-associated zinc-finger protein, Miz1, activates transcription of... | 17th October, 2008
| Institute of Molecular Biology and Tumor Research, Philipps University
| EMBO J. 2008 Oct 16.
DOI Direct Link |
Yeast DNA replication protein Dpb11 activates the Mec1/ATR checkpoint kinase.
The Saccharomyces cerevisiae Mec1-Ddc2 protein kinase (human ATR-ATRIP)... | 17th October, 2008
| Biochemistry & Molecular Biophysics, Washington University School of
| J Biol Chem. 2008 Oct 15.
DOI Direct Link |
Phosphorylation of cyclin D1 regulated by ATM or ATR controls cell cycle progression.
Cyclin D1 is required at high levels for passage through G(1) phase but... | 10th September, 2008
| Department of Molecular Genetics, The Lerner Research Institute, The
| Mol Cell Biol. 2008 Sep;28(17):5478-93. Epub 2008 Jul 7.
DOI Direct Link |
→View more research publications. |
TOPBP1 results (if any) from reagent suppliers | 
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TopBP1 antibody - ChIP Grade (ab2402) datasheet | Abcam
Rabbit polyclonal to TopBP1 - ChIP Grade. This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta.
http://www.abcam.com/index.html?datasheet=2402...
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TopBP1 Antibody / TopBP1 Antibodies
TopBP1 Antibody / TopBP1 Antibodies. ... TopBP1 specific siRNA and shRNA gene silencers are also available. These include: TopBP1 siRNA (h): sc-41068, ...
http://www.scbt.com/table-topbp1.html...
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TopBP1 Antibody Bethyl Laboratories
http://www.bethyl.com/go/?product/A300-111A...
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TopBP1 (C-20) Antibody sc-22859
TopBP1 (C-20) P, sc-22859 P (peptide), 100 µg/0.5 ml ... Western blot analysis of TopBP1 expression in UV-treated HeLa whole cell lysate. Download ...
http://www.scbt.com/datasheet-22859-topbp1-c-20-antibody.htm...
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TopBP1 antibodies | Abcam
TopBP1 antibodies. ... TopBP1 antibody - ChIP Grade. IP, ICC, WB, ChIP. Images · Customer Abreviews: 5 stars (out of 5) Customer Abreviews: 5 stars (out of ...
http://www.abcam.com/index.html?t=8958&pt=1&c=562...
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TopBP1 siRNA (h) sc-41068
Recommended Control Antibody (click catalog # for product information). Product Name, Catalog #, Unit, Price, Qty, Wish List. TopBP1 (H-300), sc-32923 ...
http://www.scbt.com/datasheet-41068-topbp1-sirna-h.html...
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Protein and Antibody Solutions Provider - GenWay
TopBP1; DNA topoisomerase II binding protein, Hypothetical protein ... Rabbit polyclonal to TopBP1; 11073; TOPBP1; 607760; Q92547; TOP2BP1;, IgG Polyclonal
...
https://www.genwaybio.com/advanced_search_result.php?so=c&ig...
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Topo II Beta Antibody
Rabbit anti-TopBP1 Antibody. A300-949A. Rabbit anti-Topo II Beta Antibody, Affinity Purified. A310-306A. Topo II Beta Antibody AbVantage Pack. BP300-950
...
https://www.bethyl.com/product/pdf/A300-950A.pdf...
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Product Name Index
TopBP1 Antibody / TopBP1 Antibodies · Topo Antibody / Topo Antibodies · TOPORS Antibody / TOPORS Antibodies · Tor1 Antibody / Tor1 Antibodies ...
http://www.scbt.com/letter.php?letter=T&page=10...
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ATRIP Antibody #2737
ATR associated with ATRIP can also be stimulated by topoisomerase II binding protein (TOPBP1), suggesting that ATRIP may regulate both ATR localization and
...
http://www.cellsignal.com/products/2737.html...
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