BioPortfolio - ADAMTS5 - ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

ADAMTS5

Symbol:

ADAMTS5

Name(s):

ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2)

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

ADAMTS11, ADMP-2, FLJ36738

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

18240210

Observational study of gene-disease association. (HuGE Navigator)

18042673

Crystal structures of the two most active human aggrecanase isoforms, ADAMTS4 and ADAMTS5, each in complex with bound inhiitor.

17991750

The catalytic domain of aggrecanase-2 has been refolded, purified, and crystallized, and its three-dimensional structure determined to 1.4A resolution in the presence of an inhibitor.

17978660

In both nucleus pulposis and anulus fibrosus, ADAMTS5 was higher in discs with a higher level of degeneration. Aggrecan fragmentation profile analysis showed the involvement of aggrecanases and other proteases during disc degeneration.

16133547

These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican.

12392761

Substrate specificity. Cleaves aggrecan at Glu(1480)-Gly(1481), Glu(1667)-Gly(1668), Glu(1771)-Ala(1772) and Glu(1871)-Leu(1872) bonds more readily than at the Glu(373)-Ala(374) bond. Additionally, in region spanning residues Gly(1481) and Glu(1667).

17430884

ADAMTS-5 is a major aggrecanase in cartilage metabolism and pathology, with aggrecanase activity at least 1,000-fold greater than that of ADAMTS-4 under physiological conditions

17067994

ADAMTS-5 expression is restricted to decidualized stromal cells of the human endometrium in vivo and is subject to regulation by cytokines in vitro.

11801682

Aggrecanase-2 mRNA and protein are constitutively produced by fibroblast-like synoviocytes from nonarthritis, osteoarthritis, and rheumatoid arthritis patients but are not increased by TGF-beta, IL-1, or TNF-alpha.

14715656

ADAMTS4 and ADAMTS5 are inhibited by alpha2-macroglobulin

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