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CHEK1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18270339 |
Observational study and meta-analysis of gene-disease association. (HuGE Navigator) |
| 17986860 |
This review of new findings demonstrates that DNA replication fork velocity (fork progression) is coordinated with inter-origin distance and that it can be actively slowed down by Chk1-dependent mechanisms in response to DNA damage. |
| 18229454 |
A side-by-side comparison of the Hsp90-dependent chaperoning of Chk1 to that of the progesterone receptor (PR) was performed to show that these distinct types of clients have different chaperoning requirements. |
| 18243098 |
CHK1 is a histone H3 threonine 11 kinase that requires DNA damage-induced transcriptional repression. |
| 18029388 |
Loss of CHK1 function impedes DNA damage-induced FANCD2 monoubiquitination but normalizes the abnormal G2 arrest in Fanconi anemia. |
| 17408908 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17684142 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17879369 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17491592 |
Chk1 regulates the density of active replication origins during the vertebrate S phase. |
| 18088187 |
suggests the unique role of Chk1 in preventing abrogation of the G2 checkpoint in p53+/+ cells | →View more information from publications. |
Recent Publications on CHEK1: |  |
Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response.
To investigate drug mechanisms of action and identify molecular targets... | 29th October, 2009
| Laboratory of Molecular Pharmacology, Genetics Branch, Center for Cancer
| J Biol Chem. 2009 Jul 3;284(27):18085-95. Epub 2009 May 5.
DOI Direct Link |
Malignant pleural mesothelioma: Genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets.
Malignant pleural mesothelioma is an asbestos-related multi-resistant... | 22nd April, 2009
| Department of Oncology, St. Olavs Hospital, Trondheim, Norway; Department
| Lung Cancer. 2009 Apr 18.
DOI Direct Link |
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
BACKGROUND: The recurrent immunoglobulin translocation, t(4;14)(p16;q32)... | 13th February, 2009
| Institute for Cancer Research, Section of Haemato-Oncology, London, UK.
| Haematologica. 2009 Jan;94(1):78-86. Epub 2008 Dec 4.
DOI Direct Link |
Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus.
A second class II AP endonuclease, APEX2, possesses strong 3'-5'... | 24th December, 2008
| Division of Neurofunctional Genomics, Medical Institute of Bioregulation,
| DNA Repair (Amst). 2008 Sep 1;7(9):1437-54. Epub 2008 Jun 27.
DOI Direct Link |
Discovery of a novel class of 2-ureido thiophene carboxamide checkpoint kinase inhibitors.
Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that... | 18th November, 2008
| AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.
| Bioorg Med Chem Lett. 2008 Jul 15;18(14):4242-8. Epub 2008 May 6.
DOI Direct Link |
→View more research publications. |
CHEK1 results (if any) from reagent suppliers | 
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CHEK1 Antibody
Specific antibody for the gene product of CHEK1, the protein Checkpoint homolog 1. Validated for specificity by gene-silencing with siRNA followed by ...
http://www.piercenet.com/products/browse.cfm?fldID=04399F20-...
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CHEK1 antibody, CHK1 checkpoint homolog (S. pombe) (CHEK1 ...
Mouse monoclonal anti-human 2178C1a antibody; EC 2.7.11.1; Homo sapiens CHK1 checkpoint homolog (S. pombe) (CHEK1), mRNA; Serine/threonine-protein kinase ...
http://www.genwaybio.com/product_info.php?products_id=60186...
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Rabbit anti-Chk1 Antibody BL235, affinity purified
Chek1 Antibody, Anti-Checkpoint Antibody. Produced in Rabbit. Catalog No. Size ... Alternative Names: Chk1, Chk-1, Chek1, Checkpoint. Kinase 1. ...
http://www.natutec.de/pdf_bethyl/A300-298A.pdf...
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CHEK1 peptide, Chk1 (Ab-280) Antibody Blocking Peptide peptide
Buy quality CHEK1 peptide (n/a), CHEK1, Chk1 (Ab-280) Antibody Blocking Peptide peptide, (n/an/a). EC 2.7.11.1; Serine/threonine-protein kinase Chk1, ...
http://www.genwaybio.com/product_info.php?products_id=213317...
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CKOZFN1012 CompoZr™ Knockout ZFN Kit human CHEK1 (NM_001274)
CKOZFN1012 CompoZr Knockout ZFN Kit human CHEK1 (NM_001274) CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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BRCA1 peptide, BRCA1 (Ab-1423) Antibody Blocking Peptide peptide
Interacts with CHEK1/CHK1. Interacts with BRCC3. Interacts (via BRCT domains) with ACACA (phosphorylated); the interaction prevents dephosphorylation of ...
http://www.genwaybio.com/product_info.php?products_id=213396...
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Search Results
5 Matches Found For CHEK1. 1. Sort By : ... Monoclonal Anti-CHEK1 antibody produced in mouse (1). 別名: Anti-CHK1 checkpoint homolog (S. pombe), Anti-CHK1,
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http://www.sigmaaldrich.com/catalog/Lookup.do?D7=0&D10=CHEK1...
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