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FAF1


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Gene DB Home
Symbol:FAF1
Name(s):Fas (TNFRSF6) associated factor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:CGI-03, FLJ37524, HFAF1s, hFAF1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17999750 Fas expression was reduced and caspase-10 activity was decreased in both patients
17684021 FAF1 robustly suppresses NF-kappaB activation through the inhibition of IKK activation in combination with previously reported cytoplasmic retention of NF-kappaB p65
15743842 hFAF1 may serve as a scaffolding protein that regulates protein degradation in the ubiquitin-proteasome pathway.
17046979 FAF1 functions as a negative regulator of an NF-kappaB signal pathway that involves PYPAF1 and ASC.
12963981 FAS-associated factor 1 is specifically reduced in human gastric carcinomas
14600157 a novel function of FAF1: NF-kappaB activity suppressor by cytoplasmic retention of NF-kappaB p65 via physical interaction.
12702723 FAF1 is a member of Fas-DISC acting upstream of caspase-8
15596450 hFAF1 prevents cells from recovery after stress by binding to and inhibiting the chaperone activity of Hsp70
12832043 phosphorylation by protein kinase CK2 influencing transport into nucleus

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDFas receptorFAS-associated factor 1--Pubmed
HPRDtumor necrosis factor receptor superfamily, member 6 isoform 1 precursorFAS associated factor 1--Pubmed
HPRDcaspase 8 isoform A precursorFAS-associated factor 1--Pubmed
HPRDCasein kinase II, betaFAS-associated factor 1--Pubmed
HPRDcasein kinase 2, beta polypeptideFAS associated factor 1--Pubmed
HPRDFAS-associated factor 1UBX domain containing 8--Pubmed

Recent Publications on FAF1:

Pubmed Logo
FAS-associated factor 1 (FAF1): diverse functions and implications for oncogenesis.
FAS-associated factor 1, FAF1, is an evolutionarily conserved protein that...
29th October, 2009
Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, Cell Cycle. 2009 Aug 15;8(16):2528-34. Epub 2009 Aug 16.
Structure and interaction of ubiquitin-associated domain of human Fas-associated factor 1.
Fas-associated factor (FAF)-1 is a multidomain protein that was first...
2nd September, 2009
Magnetic Resonance Team, Korea Basic Science Institute, 804-1 Protein Sci. 2009 Nov;18(11):2265-76.
DOI Direct Link
Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis.
Vanilloid receptor1 (VR1/TRPV1) is expressed on peripheral nerves and...
3rd July, 2009
Center for Immunotherapy of Cancer and Infectious Diseases, University of Cancer Lett. 2009 Jun 29.
DOI Direct Link
Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.
Mantle cell lymphoma (MCL) is genetically characterized by the...
2nd May, 2009
Hematopathology Unit, Department of Pathology, Hospital Clinic, Institut Blood. 2009 Mar 26;113(13):3059-69. Epub 2008 Nov 4.
DOI Direct Link
Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice.
The human CDKN2A locus encodes 2 distinct proteins, p16(INK4A) and...
2nd April, 2009
Human Genetics Program, Fox Chase Cancer Center, Philadelphia, PA 19111, Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3420-5. Epub 2009 Feb 17.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
5675458 Magnetic recording/reproducing apparatus with independently tiltable head drum and tape lead guide
6470674 Deterioration detecting apparatus and method for engine exhaust gas purifying device
6479241 High throughput screening of the effects of anti-cancer agents on expression of cancer related genes in various cell lines
6524583 Antibody methods for selectively inhibiting VEGF
6538173 Compositions and methods for wound healing

View more patents.

FAF1 results (if any) from reagent suppliers

Google CSE Logo
FAF1 Antibody #4932
Polyclonal antibodies are prepared by immunizing rabbits with synthetic peptides (KLH-coupled) corresponding to a central region of FAF1 around residue 260. ...
http://www.cellsignal.com/products/4932.html...

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FAF1 Antibody (CT) Fas-associated protein 1
FAF1 antibody can be used for detection of FAF1 by Western blot at 1 – 2 ug/ml.,
http://www.prosci-inc.com/shop/catalog1/FAF1-Antibody-p-6462...

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FAF1 (M-20) Antibody sc-1885
See how others have used FAF1 (M-20): sc-1885 antibody and or FAF1 ... Fas- associated factor 1, FAF1, is a member of Fas death-inducing signaling complex.
...
http://www.scbt.com/datasheet-1885-faf1-m-20-antibody.html...

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Protein Modification - Ubiquitination Antibody
AP2182a, Epsin2 Antibody (N-term), WB, IHC, E, H, M. AT1991aNEW, FAF1 monoclonal antibody (M01), ELISA,IF,WB-Ce,WB-Re, H. AP1600b, FAU Antibody (C-term) ...
http://www.abgent.com/products/category/protein_modification...

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FAF1 (92-B) Antibody sc-101255
Western blot analysis of FAF1 expression in HeLa whole cell lysate. sc-101255. FAF1 (92-B): sc-101255. Immunofluorescence staining of paraformaldehyde-fixed
...
http://www.scbt.com/datasheet-101255-faf1-92-b-antibody.html...

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Custom AntibodyArray (HM6000) Antibody Selection and Price ...
FAF-1. FAK. Fas. FasL. FAST. FGFR1. FGFR2. FGFR3. FGFR4. FHIT. FLASH. FLIPs/l. Flt-3/2. Flt-4 c-Fos. Frizzled. GADD34. GADD45. GADD153. GAK. GATA-1. GATA-2 ...
http://www.hypromatrix.com/Store/html/customarrayorder.pdf...

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FAF1 Antibody / FAF1 Antibodies
FAF1 Antibody / FAF1 Antibodies. ... FAF1 spezifische siRNA, sHRNA Plasmide und shRNA Lentivirale Partikel Gen Silencer sind ebenfalls erhältlich. ...
http://www.scbt.com/de/table-faf1.html...

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