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CHGA


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Symbol:CHGA
Name(s):chromogranin A (parathyroid secretory protein 1)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CGA
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18235090 Observational study of gene-disease association. (HuGE Navigator)
18235090 common variants associate with the risk of hypertensive end-stage renal disease in blacks
17991725 the Pro370Leu CHGA gene variant may contribute to the differential prevalence of cardiovascular disease across ethnic groups
18061980 Serum chromogranin A (CHGA) levels were higher in Rheumatoid arthritis (RA) and lupus erythematosus than in healthy subjects and density of CHGA+ cells was higher in RA synovium compared to osteoarthritis controls
16504480 Observational study of gene-disease association. (HuGE Navigator)
17438153 Observational study of gene-disease association. (HuGE Navigator)
17438154 Observational study of gene-disease association. (HuGE Navigator)
18046660 Phaeochromocytomas from multiple endocrine neoplasia type 2 patients express substantially more CGA than tumours from von Hippel-Lindau patients at both the mRNA (3-fold greater) and protein (20-fold) level.
17578828 Octreotide suppression test with CgA level assessment in NET patients is a simple, straightforward examination, providing information on the predicted response to the applied SSA and the data on initial clinical tolerance of those agents.
17929277 The finding that PGP 9.5 and ChA are expressed by PC-3 and DU145 cells suggests that these cells may have been derived from metastatic adenocarcinomas which had undergone neuroendocrine differentiation or expression occurred as a result of cell culture.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDChromogranin Asecretogranin III--Pubmed
HPRDchromogranin A precursorplasminogen--Pubmed

Recent Publications on CHGA:

Pubmed Logo
The importance of chromogranin A in the development and function of endocrine pancreas.
BACKGROUND: Chromogranin (Cg) A is expressed in neuroendocrine and...
30th August, 2008
Department of Genetics and Pathology, Clinical Chemistry, Uppsala Regul Pept. 2008 Aug 3.
DOI Direct Link
Heritability and genome-wide linkage in US and australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure.
BACKGROUND: Chromogranin A (CHGA) triggers catecholamine secretory granule...
14th August, 2008
Departments of Medicine and Pharmacology and Center for Human Genetics and Circulation. 2008 Jul 15;118(3):247-57. Epub 2008 Jun 30.
DOI Direct Link
ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells.
Islet cell autoantigen of 69kDa (ICA69) is a small GTPase-binding protein...
13th August, 2008
Experimental Diabetology, Carl Gustav Carus School of Medicine, Dresden Eur J Cell Biol. 2008 Apr;87(4):197-209. Epub 2008 Jan 9.
DOI Direct Link
Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.
Chromogranin A (CHGA) is stored and released from the same secretory...
31st July, 2008
Department of Medicine, Center for Human Genetics and Genomics, University Kidney Int. 2008 Jul;74(1):115-25. Epub 2008 Apr 23.
DOI Direct Link
The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion.
Secretion of proteins and peptides from eukaryotic cells takes place by...
17th July, 2008
Department of Medicine, Center for Human Genetics and Genomics, University Biochemistry. 2008 Jul 8;47(27):7167-78. Epub 2008 Jun 13.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Effects of Octreotide Acetate on Circulating Levels of Chromogranin A in Advanced Prostate Cancer Patients
Prostate Cancer

Patents:

Patents logo
US Patent No.Title
7414381 Charging circuit for parallel charging in multiple battery systems
6577719 Method and system for the processing of tariff data
6593300 (3R)-3-amino-4-carboxybutyraldehyde derivatives inhibiting the release of interleukin-1/beta
6727063 Single nucleotide polymorphisms in genes
6879134 Selector circuit for power management in multiple battery systems

View more patents.

CHGA results (if any) from reagent suppliers

Google CSE Logo
Genetex Inc. - Source for antibody, antibodies, monoclonal ...
PRODUCTNAME) LIKE '%CHGA%' OR UPPER(p.MANUFACTURERPARTNUM) LIKE '%CHGA%' OR UPPER(p.SKU) LIKE '%CHGA%' OR UPPER(p.SEARCHKEYWORD) LIKE '%CHGA%') ...
http://www.genetex.com/commerce/catalog/srhkeyword.cz?keywor...

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Primary Antibodies - GenWay Biotech Inc.
Chromogranin A; 1113; CHGA; 118910; P10645; CGA; - Monoclonal Rabbit Antibody to Human Chromogranin A;, IgG Monoclonal IHC-P, Source: Rabbit Reactivity: N/A ...
https://www.genwaybio.com/all_primary_antibodies.php?fl=C&so...

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Chr-A (C-20) Antibody sc-1488
Number. Human, CHGA, 1113, 14q32.12, NM_001275 · P10645 · 118910. Mouse, Chga, 12652, 12 E, P26339, N/A. Ordering Information. Product Name, Catalog #, Unit
...
http://www.scbt.com/datasheet-1488-chr-a-c-20-antibody.html...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
CHGA; - CgA; Pituitary secretory protein I; SP-I; Chromogranin A; Chromogranin-A , IgG Polyclonal WB, Source: Rabbit Reactivity: Human, Mouse, Rat ...
https://www.genwaybio.com/all_polyclonal_antibodies.php?fl=C...

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Chr-A (LK2H10) Antibody sc-47714
ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CHGA, 1113, 14q32.12, NM_001275 · P10645 ...
http://www.scbt.com/datasheet-47714-chr-a-lk2h10-antibody.ht...

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BioVendor - Research and Diagnostic Products \ Products \ Immunoassays
... Chromogranin A ( Pituitary secretory protein I , CgA, SP-I, CHGA), CINC-1 ( Cytokine-Induced Neutrophil Chemoatractant), Clara Cell Protein (CC10, CC16, ...
http://www.biovendor.com/products/immunoassays/search/l...

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Chromogranin Antibody / Chromogranin Antibodies
Search. Advanced Search. Browse our Catalog, Protein A, G PLUS or L-Agarose, Alexa Fluor® Conjugated Primary Antibodies, Tumor Suppressors/Apoptosis ...
http://www.scbt.com/table-chromogranin.html...

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BioVendor - Research and Diagnostic Products \ Molecules ...
Chromogranin A ( Pituitary secretory protein I , CgA, SP-I, CHGA). Chromogranin A is an acidic secretory protein consisting of 439 amino acids. ...
http://www.biovendor.com/molecule/chromogranin-a...

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MALDI-TOF-MS as a Tool In Prokaryotic Identification Laminin I ...
Chromogranin A (parathyroid secretory protein 1): CHGA, 1113. HP75. CRL-2506. human. P+. HPAC. CRL-2119. human. P–. Ciliary neurotrophic factor receptor: ...
http://www.atcc.org/Portals/1/Pdf/atccv24no1.pdf...

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BioVendor - Research and Diagnostic Products \ Products ...
Other names: Pituitary secretory protein I , CgA, SP-I, CHGA. Cat. No.: RSCYK070R, Regulatory status: RUO. Size: 96 wells (1 kit), | ...
http://www.biovendor.com/product/immunoassays/chromogranin-a...

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