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CHEK2


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Symbol:CHEK2
Name(s):CHK2 checkpoint homolog (S. pombe)
Type:protein-coding
Organism:Homo sapiens
Synonyms:CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18253122 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
18281249 Observational study of gene-disease association. (HuGE Navigator)
17164383 Observational study of gene-disease association. (HuGE Navigator)
17214356 Observational study of gene-disease association. (HuGE Navigator)
17250914 Observational study of gene-disease association. (HuGE Navigator)
17333333 Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator)
17333477 Observational study of genotype prevalence. (HuGE Navigator)
17341484 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17372254 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDataxia telangiectasia mutated protein isoform 1protein kinase CHK2 isoform aATM phosphorylates Chk2 at threonine 68.-Pubmed
BINDataxia telangiectasia mutated protein isoform 1protein kinase CHK2 isoform aATM phosphorylates Chk2 at threonine 68.-Pubmed
HPRDBRCA1protein kinase CHK2 isoform a--Pubmed
HPRDbreast cancer 1, early onset isoform 1CHK2--Pubmed
HPRDCytokine inducible kinaseprotein kinase CHK2 isoform a--Pubmed
HPRDpolo-like kinase 3CHK2--Pubmed
HPRDERCC6protein kinase CHK2 isoform a--Pubmed
HPRDexcision repair cross-complementing rodent repair deficiency, complementation group 6CHK2--Pubmed
HPRDMacrophage mannose receptorprotein kinase CHK2 isoform a--Pubmed
HPRDmannose receptor C type 1 precursorCHK2--Pubmed

Recent Publications on CHEK2:

Pubmed Logo
CHEK2 mutations and HNPCC - related colorectal cancer.
Recently, the 1100delC variant of CHEK2 has been reported to confer a...
31st October, 2009
International Hereditary Cancer Center, Department of Genetics and Int J Cancer. 2009 Oct 28.
DOI Direct Link
The contribution of founder mutations to early-onset breast cancer in French-Canadian women.
In an ethnically-homogeneous population, it is valuable to identify...
30th October, 2009
Epidemiology Research Unit, Research Centre, Centre hospitalier de Clin Genet. 2009 Nov;76(5):421-6.
DOI Direct Link
Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations.
Identification and characterization of the genetic variants underlying...
27th October, 2009
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, Acta Diabetol. 2009 Oct 24.
DOI Direct Link
Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias.
The CHEK2 kinase (Chk2 in mouse) is a member of a DNA damage response...
7th October, 2009
Department of Molecular Genetics, University of Cincinnati College of Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):17111-6. Epub 2009 Sep 21.
DOI Direct Link
The associations of sequence variants in DNA-repair and cell-cycle genes with cancer risk: genotype-phenotype correlations.
DNA-repair systems maintain the integrity of the human genome, and...
30th September, 2009
Institut Curie-Recherche, Centre Universitaire, Orsay, France. Biochem Soc Trans. 2009 Jun;37(Pt 3):527-33.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7485468 Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
7452887 Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
7410988 2-Amido-thiazole-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof
7407755 Determining a predisposition to cancer
7319007 Determining a predisposition to cancer

View more patents.

CHEK2 results (if any) from reagent suppliers

Google CSE Logo
CHEK2 Antibody
Specific antibody for the gene product of CHEK2, the protein Checkpoint homolog 2. Validated for specificity by gene-silencing with siRNA followed by ...
http://www.piercenet.com/products/Browse.cfm?fldID=A3F39DA0-...

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Chk2 (A-12) Antibody sc-5278
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CHEK2, 11200, 22q12.1, NM_001005735,
...
http://www.scbt.com/datasheet-5278-chk2-a-12-antibody.html...

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Search Results
CHEK2抗体 ウサギ宿主抗体 (2). Anti-CHEK2 antibody produced in rabbit ... Monoclonal Anti-CHEK2 antibody produced in mouse (1) ...
http://www.sigmaaldrich.com/catalog/Lookup.do?D7=0&D10=CHEK2...

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Product Specification Sheet
Background Information: CHK2 (also known as CHEK2, Protein kinase CHK2 isoform a , ... Defects in CHEK2 are also found in some patients with ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...

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Antibodies to Check Point Proteins
human ... CHEK2(11200), human, ARR, ICC, IHC (p), IP, WB, pricing. M2444, Monoclonal Anti-MDC1 antibody produced in mouse, MDC1-50 (monoclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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CD-CY
HPA001878, Anti-CHEK2 antibody produced in rabbit, affinity isolated antibody, human ... CHEK2(11200), human, IHC (p), PA, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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Apoptosis Antibodies :: Page 9
CFLAR Antibody, 49-272, H, WB, IHC, CASP8 And FADD-like Apoptosis Regulator. CHEK2 Antibody, XW-7859, H, WB, Serine/threonine-protein kinase Chk2, Cds1 ...
http://www.prosci-inc.com/shop/catalog1/Apoptosis-Antibodies...

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