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POLI


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Symbol:POLI
Name(s):polymerase (DNA directed) iota
Type:protein-coding
Organism:Homo sapiens
Synonyms:RAD30B, RAD3OB
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18270339 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
15609317 Observational study of gene-disease association. (HuGE Navigator)
16195237 Observational study of gene-disease association. (HuGE Navigator)
18194848 Observational study of gene-disease association. (HuGE Navigator)
17609217 the cation utilized by pol iota in vivo may actually be Mn(2+) rather than Mg(2+), as tacitly assumed
16166652 DNA polymerase iota promotes replication through a ring-closed minor-groove adduct that adopts a syn conformation in DNA
16472831 results show that Pol iota has no significant role in UV lesion bypass and mutagenesis in vivo and provides some initial data suggesting that this polymerase may be involved in replication of extrachromosomal DNA
15254543 crystal structure bound to a template primer and an incoming nucleotide; structure reveals a polymerase that is 'specialized' for Hoogsteen base-pairing, whereby the templating base is driven to the syn conformation
16914729 For proficient T incorporation opposite template A, only the N7 hydrogen bonding is required, but for proficient C incorporation opposite template G, hydrogen bonding at both the N7 and O(6) is an imperative.
14701763 propose that the incipient base pair is accommodated differently in the active site of Poliota dependent upon the template base and that when T is the templating base, Poliota accommodates the wobble base pair better than the Watson-Crick base pair

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDpolymerase iotaREV1-like isoform 1--Pubmed
HPRDpolymerase iotaREV1-like isoform 1--Pubmed
BINDpolymerase iotaREV1-like isoform 1hREV1 interacts with POLI.-Pubmed

Recent Publications on POLI:

Pubmed Logo
Creation of a Tool to Assess Adherence to Treatments for Acne.
Background: Acne is a disorder in which adherence has a major impact on...
24th October, 2008
Cabinet prive, Paris, France. Dermatology. 2008 Oct 22.
DOI Direct Link
Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism.
BACKGROUND: The optimal duration of anticoagulation for a first episode of...
24th October, 2008
McMaster University and St. Joseph's Hospital, Hamilton, Ontario, Canada. Ann Intern Med. 2008 Oct 7;149(7):481-90, W94.
Ligand-engaged urokinase-type plasminogen activator receptor (uPAR) and activation of the CD11b/CD18 (Mac1) integrin inhibit late events of HIV expression in monocytic cells.
Urokinase-type plasminogen activator (uPA) signaling via its receptor uPAR...
23rd October, 2008
AIDS Immunopathogenesis Unit, Division of Immunology, Transplantation and Blood. 2008 Oct 21.
DOI Direct Link
Modulation of inflammation by nutritional interventions.
Urokinase-type plasminogen activator (uPA) signaling via its receptor uPAR...
22nd October, 2008
UMR 7079, Universite Pierre et Marie Curie, 7, quai St Bernard, Bat A 5 Curr Atheroscler Rep. 2008 Dec;10(6):451-3.
[Identification of anomalous coronary arteries and their anatomic course by multidetector computed tomography coronarography. A retrospective registry.]
BACKGROUND: The coronary anomalies are generally asymptomatic and rare....
22nd October, 2008
Pole cardioneurovasculaire, centre hospitalier de Haguenau, 64, avenue du Ann Cardiol Angeiol (Paris). 2008 Sep 20.
DOI Direct Link

View more research publications.

BioNews Results for POLI

: RSS Logo
BioPortfolio Logo
Oberon wins biotech contest
Denver Business Journal:  Nov 14 2008 11:45PM Matching: poli
Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results
BC Technology:  Nov 14 2008 8:36AM Matching: poli
Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results
Huliq.com:  Nov 12 2008 9:43AM Matching: poli
Preparation of agarose coated, solid agarose beads containing secretory cells
PharmCast:  Nov 12 2008 1:03PM Matching: poli
Two of Nation's Top High School Basketball Players Headline 2008 T-Mobile Invitational
SmartBrief:  Nov 12 2008 4:32AM Matching: poli
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Effectiveness of Kneehab in Strengthening Quadriceps in Rehabilitation Post Anterior Cruciate Ligament (ACL) Reconstruction
Anterior Cruciate Ligament Reconstruction

Patents:

Patents logo
US Patent No.Title
7344863 Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
7367963 Apparatus and method for preventing free flow in an infusion line
7368446 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
7370019 Method and device for evolving a network using a genetic representation
7371741 Estradiol derivatives and pharmaceutical compositions using same

View more patents.

POLI results (if any) from reagent suppliers

Google CSE Logo
HPA012000 Anti POLI antibody produced in rabbit Prestige ...
HPA012000 Anti-POLI antibody produced in rabbit Prestige Antibodies™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...

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Pol Iota Antibody
Anti-PolI Antibody, Anti-Pol Iota Antibody. Anti-Polymerase Iota Antibody, ... PolI, Pol Iota, polymerase (DNA directed) iota, RAD30B, RAD30 homolog B. ...
https://www.bethyl.com/product/pdf/A301-304A.pdf...

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DNA pol ι (K-15) Antibody sc-13832
Number. Human, POLI, 11201, 18q21.2, NM_007195 · Q9UNA4 · 605252. Mouse, Poli, 26447, 18 E2, Q6R3M4, N/A. Mouse, Poli, 26447, 18 E2, Q6R3M4 ...
http://www.scbt.com/datasheet-13832-dna-pol-iota-k-15-antibo...

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DNA polymerase eta antibody (ab17725) datasheet | Abcam
It targets POLI to replication foci (referenced from swissprot). Alternative names for DNA polymerase eta antibody (ab17725). Database links ...
http://www.abcam.com/index.html?datasheet=17725...

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Miscellaneous
DNA polymerase iota (POLI) polyclonal antibody, PAB-11630, $175.00. DnaJ (Hsp40) homolog subfamily B member 7 (DNAJB7) polyclonal antibody, PAB-01287 ...
http://www.orbigen.com/dictionary/cat1059.htm...

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STAT3 protein, Signal transducer and activator of transcription 3 ...
[4] Liu,L., Gao,Y., Qiu,H., Miller,W.T., Poli,V. and Reich,N.C., et al. Identification of STAT3 as a specific substrate of breast tumor kinase ...
http://www.genwaybio.com/product_info.php?products_id=55123...

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Orbigen Inc. - Orbigen Inc.
DNA polymerase iota (POLI) polyclonal antibody, PAB-11630, $175.00, $175.00. Click "Update" after you have made a change in Quantity. Subtotal, $175.00 ...
http://www.orbigen.com/commerce/customer/shoppingcart/buypro...

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DNA pol ι siRNA (m) sc-37786
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Poli, 26447, 18 E2, Q6R3M4 ...
http://www.scbt.com/datasheet-37786-dna-pol-iota-sirna-m.htm...

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Orbigen Inc. - Orbigen Inc.
Williams MR, Arthur JS, Balendran A, van der Kaay J, Poli V, Cohen P, Alessi DR: The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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Targeting Trends Jan-Feb-Mar 2007
#IT-01); Keener WK, Rivera VR, Young CC, Poli MA (2006) An activity-dependent assay for ricin and related RNA N-glycosidases based on ...
http://www.atsbio.com/news/07q1_news.html...

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