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PNKP
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17650498 |
XRCC1 enhances the capacity of hPNK to discriminate between strand breaks with 5'-OH termini and those with 5'-phosphate termini; and XRCC1 stimulates hPNK activity by displacing hPNK from the phosphorylated DNA product |
| 17638872 |
polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination |
| 12032095 |
Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining |
| 16364363 |
Data show that polynucleotide kinase is associated with the PARP-1-dependent end-joining pathway, and show functional parallels between the PARP-1 and DNA-PK-dependent end-joining processes. |
| 14556639 |
First direct physical evidence for ternary complex formation involving a polynucleotide kinase, AMP-PNP, and an oligonucleotide, supports a reaction mechanism in which ATP and DNA bind simultaneously to the enzyme. |
Recent Publications on PNKP: |  |
Reconstituting bacterial RNA repair and modification in vitro.
Ribotoxins kill cells by endonucleotically cleaving essential RNAs... | 20th October, 2009
| Department of Biochemistry, University of Illinois at Urbana-Champaign,
| Science. 2009 Oct 9;326(5950):247.
DOI Direct Link |
Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase.
Human polynucleotide kinase/phosphatase (hPNKP) is a 57.1-kDa enzyme that... | 24th September, 2009
| Experimental Oncology, Cross Cancer Institute, and Departments of
| Cancer Res. 2009 Oct 1;69(19):7739-46. Epub 2009 Sep 22.
DOI Direct Link |
Specific recognition of a multiply phosphorylated motif in the DNA repair scaffold XRCC1 by the FHA domain of human PNK.
Short-patch repair of DNA single-strand breaks and gaps (SSB) is... | 16th April, 2009
| Cancer Research UK DNA Repair Enzyme Group, Section of Structural Biology,
| Nucleic Acids Res. 2009 Apr;37(5):1701-12. Epub 2009 Jan 20.
DOI Direct Link |
Polynucleotide kinase 3' phosphatase variant, dietary variables and risk of adenoma recurrence in the Polyp Prevention Trial.
Polymorphisms in a number of genes encoding for DNA repair enzymes have... | 31st July, 2008
| Cancer Prevention Fellowship Program, Office of Preventive Oncology,
| Eur J Cancer Prev. 2008 Jun;17(3):287-90.
DOI Direct Link |
A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor.
Inhibitors of poly (ADP-ribose)-polymerase-1 (PARP) are highly lethal to... | 12th June, 2008
| The Breakthrough Breast Cancer Research Centre, The Institute of Cancer
| EMBO J. 2008 May 7;27(9):1368-77. Epub 2008 Apr 3.
DOI Direct Link |
→View more research publications. |
PNKP results (if any) from reagent suppliers | 
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PNK (K-20) Antibody sc-34302
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PNKP, 11284, 19q13.33, NM_007254 ...
http://www.scbt.com/datasheet-34302-pnk-k-20-antibody.html...
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Certificate of Analysis Product: Affinity Purified Anti-PNK ...
Jilani,A., Ramotar,D., Slack,C., Ong,C., Yang,X.M., Scherer,S.W. and Lasko,D.D. (1999) Molecular cloning of the human gene, PNKP, ...
http://www.rockland-inc.com/objects/catalog/product/extras/1...
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PNK (V-20) Antibody sc-34301
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, PNKP, 11284,
19q13. ...
http://www.scbt.com/it/datasheet-34301-pnk-v-20-antibody.htm...
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PNK (V-20) Antibody sc-34301
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, PNKP, 11284, 19q13.33, NM_007254 ...
http://www.scbt.com/ja/datasheet-34301-pnk-v-20-antibody.htm...
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PNK (V-20) Antibody sc-34301
种属, 基因名称, 基因ID, 染色质位置, 亚型（mRNA）即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, PNKP, 11284, 19q13.33, NM_007254 · Q96T60 ...
http://www.scbt.com/zh/datasheet-34301-pnk-v-20-antibody.htm...
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