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LYST


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Gene DB Home
Symbol:LYST
Name(s):lysosomal trafficking regulator
Type:protein-coding
Organism:Homo sapiens
Synonyms:CHS, CHS1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18043242 CHS1/LYST protein is involved in either vesicle fusion or fission. CHS1/LYST affects hematologic, immunologic and neurologic processes. Review.
15896657 two newly described nonsense mutations are expected to give rise to a severe phenotype and the patient had absolutely no cytotoxicity by natural killer cells or cytotoxic lymphocytes
11857544 Childhood, adolescent, and adult forms of Chediak-Higashi syndrome correlate with different genotypes.
12753649 results suggest that the Beige protein interacts with at least two different partners and that the Beige protein affects cellular events, such as nuclear PtdIns(4,5)P2 localization, in addition to lysosome size
11984006 The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCalmodulin 1lysosomal trafficking regulator--Pubmed
HPRDcalmodulin 1Lysosomal trafficking regulator--Pubmed
HPRDLysosomal trafficking regulatorcasein kinase 2, beta polypeptide--Pubmed
HPRDLysosomal trafficking regulatoratrophin-1--Pubmed
HPRDLysosomal trafficking regulatortyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide--Pubmed
HPRDLysosomal trafficking regulatorestrogen-related receptor alpha--Pubmed
HPRDLysosomal trafficking regulatorhepatocyte growth factor-regulated tyrosine kinase substrate--Pubmed
HPRDLysosomal trafficking regulatormediator of RNA polymerase II transcription, subunit 12 homolog--Pubmed
HPRDLysosomal trafficking regulatorheterogeneous nuclear ribonucleoprotein M isoform a--Pubmed
HPRDLysosomal trafficking regulatortyrosine 3/tryptophan 5 -monooxygenase activation protein, theta polypeptide--Pubmed

Recent Publications on LYST:

Pubmed Logo
HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway.
HIV-1 Nef has been reported to disrupt MHC class II (MHCII)-mediated Ag...
10th September, 2009
National Institute of Immunology, New Delhi, India. J Immunol. 2009 Aug 15;183(4):2415-24. Epub 2009 Jul 20.
DOI Direct Link
Spinal cord mRNA profile in patients with ALS: comparison with transgenic mice expressing the human SOD-1 mutant.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative...
1st September, 2009
Felsenstein Medical Research Center, Department of Neurology, Rabin J Mol Neurosci. 2009 Jun;38(2):85-93. Epub 2008 Jul 24.
DOI Direct Link
A concanavalin A-like lectin domain in the CHS1/LYST protein, shared by members of the BEACH family.
CHS1/LYST, the causative protein of the Chediak-Higashi syndrome (CHS),...
19th June, 2009
INSERM, U768, Paris, F-75015, France. Bioinformatics. 2009 May 15;25(10):1219-22. Epub 2009 Mar 16.
DOI Direct Link
Lyst mutation in mice recapitulates iris defects of human exfoliation syndrome.
PURPOSE: Human eyes with exfoliation syndrome (XFS) exhibit a distinctive...
24th March, 2009
Department of Molecular Physiology, University of Iowa, Iowa City, Iowa Invest Ophthalmol Vis Sci. 2009 Mar;50(3):1205-14. Epub 2008 Nov 21.
DOI Direct Link
Prolonged survival of microencapsulated neonatal porcine islet xenografts in immune-competent mice without antirejection therapy.
Several studies have demonstrated that in vitro culture of islets...
24th February, 2009
Surgical-Medical Research Institute, Department of Surgery, University of Cell Transplant. 2008;17(10-11):1243-56.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Study of Chediak-Higashi Syndrome

Patents:

Patents logo
US Patent No.Title
7109269 Impact resistant polymer blends of crystalline polypropylene and partially crystalline, low molecular weight impact modifiers
7244805 Bimetallic zinc complex and process of producing polycarbonate using the same as polymerization catalyst
7275933 Method of manufacturing dental restorations
7281806 System and method for projecting a video image with a temporal LED combiner
7283300 Magnifying binoculars

View more patents.

LYST results (if any) from reagent suppliers

Google CSE Logo
Lyst Antibody / Lyst Antibodies
Lyst Antibody / Lyst Antibodies. ... Lyst specific siRNA, sHRNA Plasmid과 shRNA Lentiviral Particles gene silencers 도 제공합니다. ...
http://www.scbt.com/ko/table-lyst.html...

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PIAS3 antibody (ab22856) | Abcam
Lyst MJ et al. Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins. EMBO J 25:5317-28 (2006). WB; Human. PubMed: 17066076 ...
http://www.abcam.com/pias3-antibody-ab22856.html...

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Lyst siRNA (h) sc-88631
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: Lyst ...
http://www.scbt.com/ja/datasheet-88631-lyst-sirna-h.html...

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Search Results
JAX Mice Database - 000604 B6C3 a/A-T(10;13)199H +/+ Lyst/J or Lyst /J. Stock# - 000604 Strain name - B6C3 a/A-T(10;13)199H +/+ Lyst/J or ...
http://www.jax.org/search/Main.jsp?sg=4&qt=immunology&page=6...

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Lyst Antibody / Lyst Antibodies
Lyst El siRNA, el plásmido del sHRNA y los silenciadores especificos del gene de las partículas de Lentiviral del shRNA están también disponibles. ...
http://www.scbt.com/es/table-lyst.html...

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Tremendous investments are made on desulfurization systems.
lyst skimming procedure. • Consistent feed quality to the NKHT reactor improves cata- lyst performance and unit performance ...
http://www.pall.com/chemical_43650.asp...

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Search Results
JAX Mice Database - 000494 J.Cg-Oca2<+> Tyr<+> Lyst/J. Stock# - 000494 Strain name - J.Cg-Oca2<+> Tyr<+> Lyst/J JAX® Mice Database ...
http://www.jax.org/search/Main.jsp?sg=4&qt=xenograft&page=6...

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