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SLC46A1
| Symbol: | SLC46A1 | | Name(s): | solute carrier family 46 (folate transporter), member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | HCP1, MGC9564, PCFT | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18003745 |
Present information regarding structure-function and membrane targeting of the hPCFT polypeptide, as well as the mechanisms that control its steady-state expression in polarized cells. |
| 17475902 |
Data suggest that hPCFT/HCP1 is responsible for the intestinal absorption of folate and also methotrexate. |
| 17446347 |
Mutations in the PCFT gene is associated with malabsorption syndromes |
| 17156779 |
HCP1 expression in different cells implies a functional role in tissues other than the duodenum |
| 17129779 |
A loss-of-function mutation in PCFT/HCP1 is the molecular basis for hereditary folate malabsorption in a family with this disease. |
| 17335806 |
Our data revealed low-level wider expression of human HCP1 transcript in multiple tissues suggesting that it is responsible for heme transport in the body, not the intestine alone. |
Recent Publications on SLC46A1: |  |
PCFT/SLC46A1 promoter methylation and restoration of gene expression in human leukemia cells.
The proton-coupled folate transporter (PCFT/SLC46A1) displays optimal and... | 27th September, 2008
| The Fred Wyszkowski Cancer Research Laboratory, Department of Biology,
| Biochem Biophys Res Commun. 2008 Nov 28;376(4):787-92. Epub 2008 Sep 24.
DOI Direct Link |
Haem and folate transport by proton-coupled folate transporter/haem carrier protein 1 (SLC46A1).
Haem carrier protein 1 (HCP1) was originally identified and characterised... | 11th September, 2008
| Division of Nutritional Sciences, School of Biomedical and Health
| Br J Nutr. 2008 Sep 10:1-7.
DOI Direct Link |
N-linked glycosylation and its impact on the electrophoretic mobility and function of the human proton-coupled folate transporter (HsPCFT).
The human proton-coupled folate transporter (HsPCFT, SLC46A1) mediates... | 13th August, 2008
| Department of Molecular Pharmacology, Albert Einstein College of Medicine,
| Biochim Biophys Acta. 2008 Jun;1778(6):1407-14. Epub 2008 Mar 20.
DOI Direct Link |
Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model.
Proton-coupled folate transporter/heme carrier protein 1 (PCFT/HCP1) has... | 14th May, 2008
| Department of Biopharmaceutics, Graduate School of Pharmaceutical
| Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G660-8. Epub 2008
DOI Direct Link |
Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.
This laboratory recently identified a human gene that encodes a novel... | 28th December, 2007
| Department of Medicine, Albert Einstein College of Medicine, Bronx, New
| Am J Physiol Cell Physiol. 2007 Nov;293(5):C1669-78. Epub 2007 Sep 26.
DOI Direct Link |
→View more research publications. |
SLC46A1 results (if any) from reagent suppliers | 
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HCP1 (G-20) Antibody sc-54206
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Slc46a1, 52466, 11 B5, Q6PEM8 ...
http://www.scbt.com/datasheet-54206-hcp1-g-20-antibody.html...
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HCP1 (C-15) Antibody sc-54204
ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SLC46A1, 113235, 17q11.2, NM_080669 · Q96NT5 ...
http://www.scbt.com/datasheet-54204-hcp1-c-15-antibody.html...
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HCP Antibody / HCP Antibodies
Search. Advanced Search. Browse our Catalog, Protein A, G PLUS or L-Agarose, Alexa Fluor® Conjugated Primary Antibodies, Tumor Suppressors/Apoptosis ...
http://www.scbt.com/table-hcp.html...
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Chromosome 11 - Santa Cruz Biotechnology, Inc.
NaDC-1 · sc-41344, TT. Slc46a1 · 52466, 11 B5, NM_026740 · Q6PEM8 · HCP1 · sc- 72315, TT. Sarm1 · 237868, 11 B5, NM_172795 · Q6PDS3 · SARM · sc-62977, LS ...
http://www.scbt.com/chromosome.php?number=11&page=20&species...
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