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GABARAP


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Symbol:GABARAP
Name(s):GABA(A) receptor-associated protein
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ25768, MGC120154, MGC120155, MM46
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17164261 Observational study of gene-disease association. (HuGE Navigator)
16874098 Results suggest that lysosomal turnover of GABARAP-PL is activated during the differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway.
15695379 GABARAP mRNA expression and protein expression were significantly down-regulated in invasive ductal and invasive lobular carcinomas; GABARAP acts via a vesicle transport mechanism as a tumor suppressor in breast cancer.
14625090 Gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.
15977068 GABARAP and DDX 47 are involved in the apoptotic process
16339017 GABARAP does not alter receptor kinetics directly, but by facilitating surface expression of alphabetagamma receptors.
11727985 Sequence-specific 1H, 13C and 15N resonance assignments of human GABA receptor associated protein.
11727986 Backbone 1H, 13C, and 15N resonance assignments for a 14 kD protein, GABA(A) receptor associated protein (GABARAP).
11729197 We present the three-dimensional structure of GABARAP obtained by x-ray diffraction at 1.75 A resolution
11825910 Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDgamma-aminobutyric acid A receptor, gamma 2 precursorGABA(A) receptor-associated protein--Pubmed
HPRDgamma-aminobutyric acid A receptor, gamma 2 precursorGABA(A) receptor-associated protein--Pubmed
HPRDN ethylmaleimide sensitive factorGABA(A) receptor-associated protein--Pubmed
HPRDN-ethylmaleimide-sensitive factorGABA A receptor associated protein--Pubmed
HPRDtransferrin receptorGABA(A) receptor-associated protein--Pubmed
HPRDtransferrin receptorGABA(A) receptor-associated protein--Pubmed
HPRDunc-51-like kinase 1GABA A receptor associated protein--Pubmed
HPRDGephyrinGABA(A) receptor-associated protein--Pubmed
HPRDgephyrin isoform 1GABA A receptor associated protein--Pubmed
HPRDAPG7 autophagy 7-likeGABA A receptor associated protein--Pubmed

Recent Publications on GABARAP:

Pubmed Logo
C-terminal processing of GABARAP is not required for trafficking of the angiotensin II type 1A receptor.
OBJECTIVE: GABARAP, a small (117 aa) trafficking protein, binds to the...
22nd September, 2009
Laboratory of Molecular Genetics, Ochsner Clinic Foundation, New Orleans, Regul Pept. 2009 Sep 17.
DOI Direct Link
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis.
Autophagy is an important catabolic process with roles in cell survival...
18th September, 2009
Cell Biology Laboratories, Department of Biochemistry, School of Medical J Cell Sci. 2009 Jul 15;122(Pt 14):2554-66. Epub 2009 Jun 23.
DOI Direct Link
Structural and mechanistic aspects of flavoproteins.
Chromosome microdeletions or duplications are detected in 10-20% of...
17th September, 2009
Department of Biochemistry & Molecular & Cellular Biology, University of FEBS J. 2009 Aug;276(15):3929. Epub 2009 Jul 3.
DOI Direct Link
Nix directly binds to GABARAP: a possible crosstalk between apoptosis and autophagy.
Autophagy, a pathway primarily relevant for cell survival, and apoptosis,...
17th September, 2009
Institut fur Strukturbiologie und Biophysik, Forschungszentrum Julich, Autophagy. 2009 Jul;5(5):690-8. Epub 2009 Jul 20.
Structure and potential function of gamma-aminobutyrate type A receptor-associated protein.
The gamma-aminobutyrate type A receptor-associated protein (GABARAP) is a...
16th September, 2009
Institut fur Strukturbiologie und Biophysik (ISB-3), Forschungszentrum FEBS J. 2009 Sep;276(18):4989-5005. Epub 2009 Aug 6.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598080 Diagnostic assay for source of inflammation
7465542 Methods and compositions for determining risk of treatment toxicity
7442390 Method for enhancing engraftment of cells using mesenchymal progenitor cells
7371207 Estrogen receptor .alpha. regulated gene expression, related assays and therapeutics
7235358 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

GABARAP results (if any) from reagent suppliers

Google CSE Logo
GABARAP antibody (ab1133) | Abcam
Rabbit polyclonal to GABARAP. GABAa Receptor Associated Protein (GABARAP) interacts with the gamma 2 subunit of GABAa receptors. It is also a Ubiquitin
Like ...
http://www.abcam.com/GABARAP-antibody-ab1133.html...

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GABARAP (FL-117) Antibody sc-28938
See how others have used GABARAP (FL-117): sc-28938 antibody and or GABARAP (FL- 117) ... Western blot analysis of human recombinant GABARAP fusion protein. ...
http://www.scbt.com/datasheet-28938-gabarap-fl-117-antibody....

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Autophagy GABARAP Antibody (N-term)
(TOP) Western blot analysis of GABARAP (arrow) using purified Pab (Cat.#AP1821a) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently ...
http://www.abgent.com/products/catalog_no/AP1821a...

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GABARAP Antibody / GABARAP Antibodies
GABARAP Antibody / GABARAP Antibodies. ... GABARAP specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-gabarap.html...

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GABARAP monoclonal antibody(clone:1F4) : Trial Size | MBL ...
LC3, GABARAP (-aminobutyric-acid-type-A-receptor-associated protein), ... M135 -3B Anti-GABARAP (100g) PM036 Anti-LC3 (polyclonal) ...
http://www.mblintl.com/product/M135-3B...

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GABARAP (N-14) Antibody sc-9189
GABARAP shRNA (h) Lentiviral Particles, sc-41956-V, 200 µl, $595. GABARAP shRNA (m) Lentiviral Particles, sc-41957-V, 200 µl ...
http://www.scbt.com/datasheet-9189-gabarap-n-14.html...

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GABARAP polyclonal antibody : Trial Size | MBL International
LC3, GABARAP (g-aminobutyric-acid-type-A-receptor-associated protein), ... M135- 3 Anti-GABARAP (1F4) PM038 Anti-GATE-16 (polyclonal) ...
http://www.mblintl.com/product/PM037B...

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GABARAP expression receptor | GABA protein receptor | human GABA A receptor Kd | maplc3 genecard | maplc3 genecard | GABA A receptor-associated protein GABARAP | Structure and potential function of gamma-aminobutyrate type A receptor-associated protein. | Nix directly binds to GABARAP A possible crosstalk between apoptosis and autophagy pdf | GABA-A Receptor Associated Protein | .


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