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U2AF2


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Gene DB Home
Symbol:U2AF2
Name(s):U2 small nuclear RNA auxiliary factor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:U2AF65
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14576315 U2AF65 modulates the function of the PLE (poly(A)-limiting element)
16940179 Results describe the roles of the two subunits of U2AF, U2AF65 and 35, in the selection between alternative 3' splice sites associated with polypyrimidine tracts of different strengths.
12297299 U2AF35 RRM is unstructured in solution but its tertiary structure is induced upon binding to U2AF65.
16043505 identified and spatially localized sites of direct interaction between U2AF35 and U2AF65 in vivo in live cell nuclei.
16376933 Multiple U2AF65 binding sites within SF3b155 regulate conformational rearrangements during spliceosome assembly.
16809543 DEK enforces 3' splice site discrimination by U2AF; DEK phosphorylated at serines 19 and 32 associates with U2AF35, facilitates the U2AF35-AG interaction and prevents binding of U2AF65 to pyrimidine tracts not followed by AG
17024186 a direct role of the U2AF 65/CF I(m) 59 interaction in the functional coordination of splicing and 3' end processing.
16682775 Cocrystals of a U2AF65 variant with a deoxyuridine dodecamer diffract X-rays to 2.9 angstroms resolution and contain one complex per asymmetric unit.
17137510 U2AF65 associates with specific subsets of spliced mRNAs, strongly suggesting that it is involved in novel cellular functions in addition to splicing.
15694343 two members of the U2AF65 family of proteins, hCC1.3, which we call CAPERalpha, and a related protein, CAPERbeta, regulate both steroid hormone receptor-mediated transcription and alternative splicing

→View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDDEAD box polypeptide 6U2 small nuclear RNA auxiliary factor 2 isoform a--Pubmed
HPRDDEAD box polypeptide 6U2 small nuclear RNA auxiliary factor 2 isoform a--Pubmed
HPRDSFRS protein kinase 1U2 small nuclear RNA auxiliary factor 2 isoform a--Pubmed
HPRDU2 small nuclear RNA auxillary factor 1 isoform aU2 small nuclear RNA auxiliary factor 2 isoform a--Pubmed
HPRDU2 small nuclear RNA auxillary factor 1 isoform aU2 small nuclear RNA auxiliary factor 2 isoform a--Pubmed
BINDU2 small nuclear RNA auxillary factor 1 isoform aU2 small nuclear RNA auxiliary factor 2 isoform ahU2AF(65) and hU2AF(35) interact to form the U2AF splice factor heterodimer.-Pubmed
HPRDWT1U2 small nuclear RNA auxiliary factor 2 isoform a--Pubmed
HPRDWilms tumor 1 isoform DU2AF65--Pubmed
BIND-U2 small nuclear RNA auxiliary factor 2 isoform aU2AF65 interacts with an unspecified isoform of SF1 (mBBP).-Pubmed
HPRDsplicing factor 1U2 small nuclear RNA auxiliary factor 2 isoform a--Pubmed

Recent Publications on U2AF2:

Pubmed Logo
Interactome for auxiliary splicing factor U2AF(65) suggests diverse roles.
U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) is an essential...		31st October, 2009
Department of Veterinary Molecular Biology, Montana State University, Biochim Biophys Acta. 2009 Jun-Aug;1789(6-8):487-92. Epub 2009 Jun 18.
DOI Direct Link
Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes.
Introns are among the hallmarks of eukaryotic genes. Splicing of introns...		5th March, 2008
Department of Human Molecular Genetics and Biochemistry, Sackler Faculty Genome Res. 2008 Jan;18(1):88-103. Epub 2007 Nov 21.
DOI Direct Link
Mapping of a translocation breakpoint in a Peutz-Jeghers hamartoma to the putative PJS locus at 19q13.4 and mutation analysis of candidate genes in polyp and STK11-negative PJS cases.
Germ-line mutations in the serine-threonine kinase gene STK11 (LKB1) cause...		24th September, 2004
Section of Cancer Genetics, Institute of Cancer Research, Sutton, United Genes Chromosomes Cancer. 2004 Oct;41(2):163-9.
DOI Direct Link

Patents:

Patents logo
US Patent No.Title
7579434 Peptide having ability to activate cancer-related gene
6706867 DNA array sequence selection

U2AF2 results (if any) from reagent suppliers

 Google CSE Logo
U4758 Monoclonal Anti-U2AF65 antibody produced in mouse clone MC3 ...
microarray: suitable. isotype, IgG2b. Gene Information, human ... U2AF2(11338). rat ... U2af2(308335). mouse ... U2af2(22185). shipped in, dry ice ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=U475...

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U2AF65 (MC3) Antibody sc-53942
... Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, U2AF2, 11338, 19q13.42, NM_001012478, NM_007279 · P26368 ...
http://www.scbt.com/datasheet-53942-u2af65-mc3-antibody.html...

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Antibodies to Transcription Regulators
U4758, Monoclonal Anti-U2AF65 antibody produced in mouse, MC3 (monoclonal), purified immunoglobulin, human ... U2AF2(11338) mouse ... U2af2(22185) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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U2AF65 (H-300) Antibody sc-48804
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, U2AF2, 11338, 19q13.42, NM_001012478,
...
http://www.scbt.com/ja/datasheet-48804-u2af65-h-300-antibody...

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U2AF65 (H-300) Antibody sc-48804
... epitope corresponding to amino acids 1-300 mapping at the N-terminus of U2AF65 of human origin; recommended for detection of U2AF65 and U2AF2 of m, ...
http://www.scbt.com/ko/datasheet-48804-u2af65-h-300-antibody...

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U2AF65 (N-14) Antibody sc-19958
... codice accesso proteina, Numero d' ordine. Human, U2AF2, 11338, 19q13.42, NM_001012478, NM_007279 · P26368 · 191318. Mouse, U2af2, 22185, 7 A1, P26369 ...
http://www.scbt.com/it/datasheet-19958-u2af65-n-14-antibody....

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