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ADCYAP1


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Symbol:ADCYAP1
Name(s):adenylate cyclase activating polypeptide 1 (pituitary)
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC126852, PACAP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18349695 Observational study of gene-disease association. (HuGE Navigator)
11515750 Observational study of gene-disease association. (HuGE Navigator)
11968092 Observational study of gene-disease association. (HuGE Navigator)
17175032 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
17962362 The ability of PBMC to produce and to respond to PACAP might influence neuroimmune interactions that regulate pain and inflammation in chronic pancreatitis.
17387318 we provide evidence that genetic variants of the genes encoding PACAP and its receptor, PAC1, are associated with schizophrenia.
16493055 PACAP27 specifically activates human neutrophils by activating formyl peptide receptor-like 1 (FPRL1).
17470806 structure of the N-terminal EC domain of the hPAC1-RS receptor in complex with the PACAP (6'-38') peptide antagonist; identified hormone residues that are critical for binding to the N-terminal EC domain of PAC1-RS
12409223 PACAP might play a role in the regulation of colon cancer growth and modulation of T lymphocyte anti-tumoral response via the Fas-R/Fas-L apoptotic pathway
12409225 PACAP-27 phosphorylates mitogen activated protein kinase and increases VEGF expression in lung cancer cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDadenylate cyclase activating polypeptide precursorPACAP receptor--Pubmed

Recent Publications on ADCYAP1:

Pubmed Logo
Intracranial self-stimulation to the lateral hypothalamus, a memory improving treatment, results in hippocampal changes in gene expression.
Intracranial self-stimulation (ICSS) within the medial forebrain bundle of...
17th September, 2009
Universitat de Girona, Departament de Biologia, Facultat de Ciencies, Neuroscience. 2009 Aug 18;162(2):359-74. Epub 2009 May 5.
DOI Direct Link
Calmodulin interacts with PAC1 and VPAC2 receptors and regulates PACAP-induced FOS expression in human neuroblastoma cells.
The neuropeptide pituitary adenylate cyclase-activating polypeptide...
20th August, 2009
Department of Clinical Biochemistry, Bispebjerg Hospital, Faculty of Neuropeptides. 2009 Apr;43(2):53-61. Epub 2009 Mar 6.
DOI Direct Link
Pulse frequency-dependent gonadotropin gene expression by adenylate cyclase-activating polypeptide 1 in perifused mouse pituitary gonadotroph LbetaT2 cells.
We examined how pulsatile stimulation with adenylate cyclase-activating...
22nd May, 2009
Department of Obstetrics and Gynecology, Shimane University School of Biol Reprod. 2009 Sep;81(3):465-72. Epub 2009 May 20.
DOI Direct Link
Search for informative polymorphisms in candidate genes: clock genes and circadian behaviour in blue tits.
The identification of functional polymorphisms in genes that underlie...
9th May, 2009
Max Planck Institute for Ornithology (Seewiesen), Postfach 1564, 82305 Genetica. 2009 May;136(1):109-17. Epub 2008 Sep 16.
DOI Direct Link
beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells.
In pancreatic beta-cells, the pituitary adenylate cyclase-activating...
1st April, 2009
Institut de Genomique Fonctionnelle, CNRS, Unite Mixte de Recherche 5203, J Biol Chem. 2009 Feb 13;284(7):4332-42. Epub 2008 Dec 11.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression

Patents:

Patents logo
US Patent No.Title
7599933 Coupled two-way clustering analysis of data
7588767 Microorganisms for therapy
7447594 Molecular cardiotoxicology modeling
7426441 Methods for determining renal toxins
7415358 Molecular toxicology modeling

View more patents.

ADCYAP1 results (if any) from reagent suppliers

Google CSE Logo
PACAP (F-2) Antibody sc-166180
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADCYAP1, 116, 18p11.32, P18509 ...
http://www.scbt.com/datasheet-166180-pacap-f-2-antibody.html...

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Neruoscience - GenWay Biotech, Inc.
ADCYAP1 ...
http://www.genwaybio.com/gw_file.php?fid=2014...

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VIP (M-19) Antibody sc-7841
Mouse, Adcyap1, 11516, 17 E5, O70176, N/A. Mouse, Vip, 22353, 10 A1, P32648, N/A . Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List ...
http://www.scbt.com/datasheet-7841-vip-m-19-antibody.html...

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A6938 Pituitary adenylate cyclase activating polypeptide amide ...
composition, Peptide content, ~65%. Gene Information, human ... ADCYAP1(116). storage temp. −20°C. Safety. Personal Protective Equipment, Eyeshields, ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A693...

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A1439 Pituitary adenylate cyclase activating polypeptide-38 PACAP-38
composition, Peptide content, ~70%. Gene Information, human ... ADCYAP1(116). storage temp. −20°C. Safety. Personal Protective Equipment, Eyeshields, ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A143...

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