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ADCYAP1R1
| Symbol: | ADCYAP1R1 | | Name(s): | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | PAC1, PACAPR, PACAPRI | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16888199 |
PACAP may regulate the biological release of peptides and serotonin from BON cells |
| 17470806 |
structure of the N-terminal EC domain of the hPAC1-RS receptor in complex with the PACAP (6'-38') peptide antagonist; identified hormone residues that are critical for binding to the N-terminal EC domain of PAC1-RS |
| 16572459 |
PAC1-R is the predominant PACAP receptor found in fetuses, and both PAC1-R and VPAC1-R are expressed in the mature cerebellum. |
| 11930171 |
PACAP receptor type 1 mRNA is expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional). |
| 16226889 |
Results show that the combination of different amino terminal and intracellular loop 3 splicing variants in the PAC1 receptor dictates the ability of agonists, including PACAP and VIP, to activate signaling pathways. |
| 16401644 |
Stimulation of endogenously expressed PAC1 receptors with PACAP in human neuroblastoma cells increased APPsalpha secretion. PAC1R activation stimulates ERK phosphorylation. |
| 14742913 |
In colon cancer cell lines, PAC1 is expressed as the SV1 or HIP splice variant and is coupled to the activation only of cAMP but not of intracellular Ca2+. |
| 16823490 |
Data demonstrate that altered neuronal proliferation/apoptosis and disrupted ependymal cilia are the main factors contributing to hydrocephalus in PAC1-overexpressing mice. |
| 12573802 |
possible role for PACAP in the regulation of expression of genes encoding catecholamine-synthesizing enzymes in intra-adrenal pheochromocytomas |
| 12409223 |
HCT8 human colon tumor cells express PAC1, and PAC1 activation is coupled to adenylate cyclase, increase cytosolic [Ca(2+)](i), and cellular proliferation | →View more information from publications. |
Recent Publications on ADCYAP1R1: |  |
beta-Arrestin 1 is required for PAC1 receptor-mediated potentiation of long-lasting ERK1/2 activation by glucose in pancreatic beta-cells.
In pancreatic beta-cells, the pituitary adenylate cyclase-activating... | 1st April, 2009
| Institut de Genomique Fonctionnelle, CNRS, Unite Mixte de Recherche 5203,
| J Biol Chem. 2009 Feb 13;284(7):4332-42. Epub 2008 Dec 11.
DOI Direct Link |
Performance of PAC1-R heterozygous mice in memory tasks-II.
An involvement of pituitary adenylate cyclase activating... | 20th February, 2009
| Laboratory of Integrative Medicine, US-Japan Cooperative Biomedical
| J Mol Neurosci. 2008 Nov;36(1-3):208-19. Epub 2008 Sep 10.
DOI Direct Link |
Granule cell survival is deficient in PAC1-/- mutant cerebellum.
PACAP exerts neuroprotective effects during development, especially in the... | 20th February, 2009
| Department of Neuroscience and Cell Biology, UMDNJ-Robert Wood Johnson
| J Mol Neurosci. 2008 Nov;36(1-3):38-44. Epub 2008 Apr 12.
DOI Direct Link |
Mice lacking the PACAP type I receptor have impaired photic entrainment and negative masking.
The retinohypothalamic tract (RHT) is a retinofugal neuronal pathway... | 23rd January, 2009
| Department of Clinical Biochemistry, Bispebjerg Hospital, Copenhagen,
| Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R2050-8. Epub 2008
DOI Direct Link |
Novel stable PACAP analogs with potent activity towards the PAC1 receptor.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a 38- or... | 8th August, 2008
| INRS-Institut Armand-Frappier, Institut National de la Recherche
| Peptides. 2008 Jun;29(6):919-32. Epub 2008 Feb 13.
DOI Direct Link |
→View more research publications. |
ADCYAP1R1 results (if any) from reagent suppliers | 
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PACAP Receptor (K-20) Antibody sc-15964
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADCYAP1R1, 117, 7p15.1, NM_001118 ...
http://www.scbt.com/datasheet-15964-pacap-receptor-k-20-anti...
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Abgent - Cell and Function Antibodies
AT1052a, ADCYAP1R1 monoclonal antibody (M01), ELISA,WB-Ce,WB-Re, H. AT1053a, ADD1 monoclonal antibody (M01), ELISA,IHC-P,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...
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PACAP Receptor siRNA (m) sc-40280
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Adcyap1r1, 11517, 6 B3, P70205 ...
http://www.scbt.com/datasheet-40280-pacap-receptor-sirna-m.h...
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Cell-Based GPCR Reporter Assays
K1706 · K1305, X, cAMP. VIP & PACAP, ADCYAP1R1 (PAC1), PDF Download · K1525 · K1619, X, cAMP. Orphan, GPR1, PDF Download ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...
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