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AP2M1


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Symbol:AP2M1
Name(s):adaptor-related protein complex 2, mu 1 subunit
Type:protein-coding
Organism:Homo sapiens
Synonyms:AP50, CLAPM1, mu2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18032517 These results thus identify a novel type of AP-2 interaction determinant, support the notion that AP-2 is the key clathrin adaptor for the downregulation of CD4 by Nef, and reveal a previously unrecognized diversity among dileucine sorting signals.
16498080 Phosphorylation of AP-2 mu2 subunit is essential for Na+,K+-ATPase endocytosis in response to a variety of signals, such as dopamine or reactive oxygen species.
15911768 AP-2 and clathrin participate in MHC-II molecule trafficking to antigen-processing compartments.
12032142 V1H can function as an adaptor for interactions between Nef and AP-2.
15778375 AP-2 is completely dependent on both (D/E)xxxL(L/I) motifs and 20 YxxO motifs signals to mediate TCR internalization; AP2M1 interacts with tyrosine in CD3delta and CD3gamma
17290396 Results show that three genes, namely FXR1, CLAPM1 and EIF4G, are most frequently overexpressed in the center of the amplified domain in squamous cell carcinomas.
17289840 An atypical basic motif within the cytoplasmic tails of AMPA-type glutamate receptors directly associates with mu2-adaptin by a mechanism similar to the recognition of the presynaptic vesicle protein synaptotagmin 1 by AP-2.
16880396 there is a positive feedback loop consisting of endocytic cargo proteins, AP-2mu, and PIPK type I which may provide a specific pool of PI(4,5)P(2) dedicated to clathrin/AP-2-dependent receptor internalization
12644451 direct association of the adaptor complex 2 with a G protein-coupled receptor has not been reported so far and might represent a common mechanism underlying clathrin-mediated receptor endocytosis
12952941 Results indicate that AP-2 is not essential for clathrin-coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDaquaporin 4 isoform aClathrin adaptor complex AP2, MU subunit--Pubmed
HPRDCD22 moleculeadaptor-related protein complex 2, mu 1 subunit isoform a--Pubmed
HPRDCD22 moleculeadaptor-related protein complex 2, mu 1 subunit isoform a--Pubmed
HPRDClathrin adaptor complex AP2, MU subunitdoublecortin isoform a--Pubmed
HPRDAP2M1lymphocyte antigen 9--Pubmed
HPRDAP2M1furin preproprotein--Pubmed
HPRDAP2M1lysosomal-associated membrane protein 1--Pubmed
HPRDClathrin adaptor complex AP2, MU subunitEH-domain containing 2--Pubmed
HPRDClathrin adaptor complex AP2, MU subunitmultiple EGF-like-domains 10--Pubmed
HPRDadaptor-related protein complex 2, mu 1 subunit isoform aLysosome associated membrane protein 1--Pubmed

Recent Publications on AP2M1:

Pubmed Logo
High-content functional screen to identify proteins that correct F508del-CFTR function.
Cystic Fibrosis is caused by mutations in CFTR, with a deletion of a...
28th May, 2009
Program in Cell Biology, The Hospital for Sick Children, and Biochemistry Mol Cell Proteomics. 2009 Apr;8(4):780-90. Epub 2008 Dec 15.
DOI Direct Link
Prefrontal cortex AMPA receptor plasticity is crucial for cue-induced relapse to heroin-seeking.
Associative learning processes have an important role in the initiation...
5th August, 2008
Departments of Molecular and Cellular Neurobiology, VU University Nat Neurosci. 2008 Aug 1.
DOI Direct Link
Genomic structure and chromosome mapping of the genes encoding clathrin-associated adaptor medium chains mu1A (Ap1m1) and mu1B (Ap1m2).
The protein mu1B is a member of the medium chain family of the...
20th May, 2000
Department of Molecular Genetics, Chiba University Graduate School of Cytogenet Cell Genet. 1999;87(1-2):53-8.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods
7452670 Methods of identifying agents that diminish cellular toxicity associated with an .alpha.-synuclein polypeptide of Parkinson's disease in yeast
7447594 Molecular cardiotoxicology modeling

View more patents.

AP2M1 results (if any) from reagent suppliers

Google CSE Logo
Phospho-AP2M1 (Thr156) Antibody #3843
Western blot analysis of extracts from HeLa cells, serum-starved overnight and either untreated or H2O2-treated (4 mM, 30 minutes), using Phospho-AP2M1 ...
http://www.cellsignal.com/products/3843.html...

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AP2M1 antibody [EP2695Y] (ab75995) | Abcam
Rabbit monoclonal [EP2695Y] to AP2M1. AP2M1 is a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor ...
http://www.abcam.com/AP2M1-antibody-EP2695Y-ab75995.html...

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AP2M1 Antibody Adaptor-related protein complex 2 mu 1
AP2M1 antibody can be used for detection of AP2M1 by Western blot at 1 – 2 μg/ml . ,
http://www.prosci-inc.com/shop/catalog1/AP2M1-Antibody-p-689...

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Phospho-AP2M1 (Thr156) Antibody
Antibody detects endogenous levels of AP2M1 protein only when phosphorylated at Thr156. ... Thr156 of human AP2M1. Antibodies are purified by peptide ...
http://www.cellsignal.com/pdf/3843.pdf...

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AP2M1 Recombinant Protein Adaptor-related protein complex 2 ...
AP2M1 Recombinant Protein from ProSci Incorporated. Protein GI number 14917109, accesion number NP_004059.,
http://www.prosci-inc.com/shop/catalog1/AP2M1-Recombinant-Pr...

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Anti-AP2 complex subunit mu-1 Polyclonal Antibody
PA1-20839 immunogen corresponds to Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1.. This protein is a subunit of
the ...
http://www.bioreagents.com/products/productDetails/productDe...

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Product Pathways: Vesicle Trafficking
New, No. Name, Applications, Reactivity. 2171 · Alix (3A9) Mouse mAb, W, IP, H, M, R, Mk. 3843 · Phospho-AP2M1 (Thr156) Antibody, W, H, (M, R, Mk) ...
http://www.cellsignal.com/pathways/vesicle-trafficking.html...

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