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CLU


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Symbol:CLU
Name(s):clusterin
Type:protein-coding
Organism:Homo sapiens
Synonyms:AAG4, APOJ, CLI, KUB1, MGC24903, SGP-2, SGP2, SP-40, TRPM-2, TRPM2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18079682 Clusterin shows possible important functions in tumor suppression by the von Hippel-Lindau disease (VHL) gene product. May provide better understanding of retinal hemangioblastoma associated with VHL disease.
15883054 Observational study of gene-disease association. (HuGE Navigator)
15925890 Observational study of gene-disease association. (HuGE Navigator)
18082619 These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins.
17872975 Clusterin is constantly associated with altered elastic fibers in aged human skin. Clusterin exerted a chaperone-like activity and effectively inhibited UV-induced aggregation of elastin.
17451556 Under certain stress conditions, clusterin can evade the secretion pathway and reach the cytosol, and the retrotranslocation of clusterin is likely to occur through a mechanism similar to the ER-associated protein degradation pathway and involves Golgi.
17855704 may be a biomarker for longer survival in patients with surgically resected non-small cell lung cancer
17974975 CLU gene expression might play a crucial role in prostate tumorigenesis by exerting differential biological effects on normal versus tumor cells through differential processing of CLU isoforms in the two cell systems.
17512083 Clusterin induces remarkable differentiation of the functional beta cells secreting insulin in response to glucose stimulation.
17689225 Hyper-expressed form of clusterin localizes to mitochondria, inhibits cytochrome c release, and is inhibited by the proteasome.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcomplement component 7 precursorclusterin--Pubmed
HPRDcomplement component 7 precursorclusterin--Pubmed
HPRDcomplement component 7 precursorclusterin isoform 1--Pubmed
HPRDcomplement component 8, beta polypeptide preproproteinclusterin--Pubmed
HPRDcomplement component 8, beta polypeptide preproproteinclusterin--Pubmed
HPRDcomplement component 8, beta polypeptide preproproteinclusterin isoform 1--Pubmed
HPRDcomplement component 9clusterin--Pubmed
HPRDcomplement component 9clusterin--Pubmed
HPRDcomplement component 9clusterin isoform 1--Pubmed
HPRDClusterinleptin receptor--Pubmed

Recent Publications on CLU:

Pubmed Logo
Conclusions and perspectives.
Since its first discovery, CLU has been fascinating many researchers...
3rd November, 2009
Dipartimento di Medicina Sperimentale, Sezione di Biochimica, Biochimica Adv Cancer Res. 2009;105:133-50.
DOI Direct Link
Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.
In no other field has the function of clusterin (CLU) been more...
3rd November, 2009
Molecular Haematology and Cancer Biology Unit, Institute of Child Health, Adv Cancer Res. 2009;105:115-32.
DOI Direct Link
CLU "in and out": looking for a link.
Cancer cells need to interact synergistically with their surrounding...
3rd November, 2009
Department of Biopathology, Institute of Anatomic Pathology, University of Adv Cancer Res. 2009;105:93-113.
DOI Direct Link
Clusterin and chemoresistance.
Resistance to anticancer agents is one of the primary impediments to...
3rd November, 2009
Department of Immunology, H. Lee Moffitt Cancer Center, Tampa, Florida Adv Cancer Res. 2009;105:77-92.
DOI Direct Link
Clusterin (CLU) and lung cancer.
Lung cancer is the leading cause of cancer-related mortality. It is...
3rd November, 2009
Department of Oncology, Hematology and Respiratory Diseases, Section of Adv Cancer Res. 2009;105:63-76.
DOI Direct Link

View more research publications.

Press Releases on CLU:

BioPortfolio Logo
Survey Finds Majority of Americans Do Not Have A Plan To Pay For Long-Term Care 12th November, 2009 LIFE Foundation
Family and Friends 23% Health Insurance 20% Medicare 16% Savings 13% Social Security
Cellu Tissue Holdings, Inc. Files Registration Statement for Proposed Initial Public Offering of Common Stock 16th October, 2009 Cellu Tissue Holdings, Inc.

ALPHARETTA, Ga., Oct. 16 /PRNewswire/ -- Cellu Tissue Holdings, Inc. ("Cellu Tissue") today announced that it has filed a registration statement on Form S-1 with the U.S.

Continued Growth Evident With New Hire and Promotion for Lockton Dunning Benefits 7th October, 2009 Lockton

DALLAS, Oct. 7 /PRNewswire/ -- Lockton Dunning Benefits today announced the arrival of a new subject matter expert as well as internal promotion of a senior team member

Actor Chris Noth to Share Story of Loss in National Life Insurance Awareness Month 8th July, 2009 Life and Health Insurance Foundation for Education

ARLINGTON, Va., July 8 /PRNewswire/ -- This summer and fall, Chris Noth will team with the insurance industry to help tackle a big problem facing far too many American families -- the lack of

Inspired by His Mother's Financial Hardship, Author Strives to Help Women Avoid Similar Mistakes 1st April, 2009 Shak Hill

New book offers timely, poignant financial guidance geared toward women

CENTERVILLE, Va., April 1 /PRNewswire/ -- Whether through divorce, widowhood or choosing to remain

BioNews Results for CLU

: RSS Logo
BioPortfolio Logo
Medical News: Survey Finds Majority Of Americans Do Not Have A Plan To Pay For Long-Term Care
BioFind:  Nov 13 2009 1:16PM Matching: clu
SIMAP--a comprehensive database of pre-calculated protein sequence similarities, domains, annotations and clus
Bioscience Technology Online:  Nov 12 2009 7:26AM Matching: clu
Alzheimer Disease Genetics: New Alzheimer disease genetics research has been reported by scientists at Max Planck Institute for Molecular Genetics
NewsRX:  Oct 27 2009 4:24AM Matching: clu
Family fought breast cancer battle together
Villages Daily Sun:  Oct 23 2009 10:09PM Matching: clu
Cellu Tissue Holdings, Inc. Files Registration Statement for Proposed Initial Public Offering of Common Stock
KOTA Territory News:  Oct 19 2009 3:50AM Matching: clu
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Hormonal and Environmental Risk Factors for Developing Systemic Lupus Erythematosus: The Carolina Lupus (CLU) Study

Patents:

Patents logo
US Patent No.Title
7287607 Directional drilling apparatus
7386818 Efficient modeling of embedded memories in bounded memory checking
7404783 Dynamo-electric drive unit controlled compound power system
7409360 Method and system for computer-based auctioning of basic generation services
7415358 Molecular toxicology modeling

View more patents.

CLU results (if any) from reagent suppliers

Google CSE Logo
Clusterin antibody, Clusterin [CLI-9] Antibody, Mouse Monoclonal ...
Mouse monoclonal [CLI - 9] to Clusterin; 1191; CLU; 185430; P10909; AAG4; APOJ; CLI; KUB1; MGC24903; SGP-2; SGP2; SP-40; TRPM-2; TRPM2;; Clusterin, ...
http://www.genwaybio.com/product_info.php?products_id=191243...

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Clusterin-α (M-18) Antibody sc-6420
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CLU, 1191, 8p21.1, NM_001831, ...
http://www.scbt.com/datasheet-6420-clusterin-alpha-m-18-anti...

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CD-CY
HPA000572, Anti-CLU antibody produced in rabbit, affinity isolated antibody, human ... CLU(1191), human, IHC (p), PA, WB, pricing ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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ER Stress Antibody Sampler Kit
clu d in g th o se u n d e r U . S . P a te n ts N o . 5. ,6. 7. 5. ,0. 6. 3 a n d in so m e in sta n ce s 7. ,4. 2. 9. ,4. 8. 7. ) fro m. E p ito m ics, In ...
http://www.cellsignal.com/pdf/9956.pdf...

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Clusterin (human) Competitive ELISA Kit - Enzo Life Sciences
CLU (human) Competitive ELISA Kit SGP-2 (human) Competitive ELISA Kit. PRODUCT LINE, Cell Cycle. PRODUCT CATEGORY, Clusterin / Related Products ...
http://www.enzolifesciences.com/AG-CC06H2/clusterin-human-co...

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Abgent - Cell and Function Antibodies
AT1563aNEW, CLTB monoclonal antibody (M01), ELISA,IF,IHC-P,WB-Ce,WB-Re, H. AT1564aNEW, CLU monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

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Clusterin (human), pAb - Enzo Life Sciences
5 Oct 2009 ... CLU SGP-2. PRODUCT LINE, Cell Cycle. PRODUCT CATEGORY, Clusterin / Related Products. Ordering Information. Product Numbers: Format: Size: ...
http://www.enzolifesciences.com/ALX-210-443/clusterin-human-...

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