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CLTC
| Symbol: | CLTC | | Name(s): | clathrin, heavy chain (Hc) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CHC, CHC17, CLH-17, CLTCL2, Hc, KIAA0034 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18042253 |
The clathrin inhibitor phenylarsine oxide prevented SubAB entry and BiP cleavage in SubAB-treated Vero, HeLa and N2A cells demonstrating that SubAB internalization is clathrin-dependent. |
| 17550971 |
Results establish a role for the retromer complex in retrograde transport of the B-subunit of Shiga toxin, and strongly suggest that clathrin and retromer function in consecutive retrograde sorting steps on early endosomes. |
| 17307723 |
Syt I plays a pivotal role in mediating cAMP- and Ca(2+)-induced endocytosis of NHE3 (but not in inhibition of activity) through cargo recognition of NHE3 and subsequent recruitment of AP2-clathrin assembly required for membrane endocytosis. |
| 12960147 |
neither clathrin nor AP-2 is essential for the internalization of epidermal growth factor |
| 15067034 |
Clathrin heavy chain phosphorylation and dephosphorylation are involved in TCR internalization; this is a regulatory mechanism linking TCR signaling to endocytosis. |
| 16138905 |
Data suggest that clathrin heavy chains bound to light chains (LC) a and b contribute to pit formation, but the affinity of LCa-free HC in pits is reduced, and the Ca(2+)- and ATP-mediated control of clathrin function is lost. |
| 12952941 |
Results indicate that AP-2 is not essential for clathrin-coated vesicle formation at the plasma membrane, but that it is one of several endocytic adaptors required for the uptake of certain cargo proteins. |
| 16618797 |
Nuclear CHC is required for the transactivation of p53 target genes and plays a distinct role from clathrin-mediated endocytosis. |
Recent Publications on CLTC: |  |
Distribution of NPM1-ALK and X-ALK fusion transcripts in paediatric anaplastic large cell lymphoma: a molecular-histological correlation.
Anaplastic large cell lymphomas (ALCL) in children express anaplastic... | 22nd September, 2009
| Department of Paediatric Haematology and Oncology, Justus-Liebig
| Br J Haematol. 2009 Aug;146(3):306-9. Epub 2009 May 26.
DOI Direct Link |
Adult-onset renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusion with smooth muscle stroma and abnormal vessels.
Renal cell carcinoma (RCC) associated with Xp11.2 translocation/TFE3 gene... | 10th September, 2009
| Department of Diagnostic Pathology, Charles University Hospital Plzen,
| Pathol Int. 2009 Jul;59(7):486-91.
DOI Direct Link |
ALK-positive diffuse large B-cell lymphoma with the t(2;17)(p23;q23).
Diffuse large B-cell lymphoma (DLBCL) with plasmablastic features... | 19th August, 2009
| Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York,
| Appl Immunohistochem Mol Morphol. 2009 Mar;17(2):172-7.
DOI Direct Link |
Growth and characterization of a new nonlinear optical crystal: [(18C6)Li][Cd(SCN)3].
Single crystals of a new nonlinear optical compound... | 18th August, 2009
| School of Material Science and Engineering, Nanchang Hangkong University,
| Spectrochim Acta A Mol Biomol Spectrosc. 2009 Oct 1;74(2):532-5. Epub 2009
DOI Direct Link |
Notation of depression in case records of older adults in community long-term care.
Although significant numbers of social service clients experience mental... | 15th April, 2009
| George Warren Brown School of Social Work, Washington University, St.
| Soc Work. 2008 Jul;53(3):243-53.
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→View more research publications. |
Press Releases on CLTC:
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| National 'Cherokee Inspired Comfort Award' Winners Announced |
13th October, 2008 |
Cherokee Uniforms |
LOS ANGELES, Oct. 13 /PRNewswire/ -- Cherokee Uniforms announced today 10
winners of the 2008 Cherokee Inspired Comfort Award. The recipients represent
a cross-section of healthcare facilities,
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CLTC results (if any) from reagent suppliers | 
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C1860 Monoclonal Anti-Clathrin Heavy Chain antibody produced in ...
isotype, IgG1. Gene Information, human ... CLTC(1213). rat ... Cltc(54241). mouse ... Cltc(67300). shipped in, dry ice. storage temp. −20°C ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C186...
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Clathrin HC (C-20) Antibody sc-6579
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CLTC, 1213, 17q23.1, NM_004859 ...
http://www.scbt.com/datasheet-6579-clathrin-hc-c-20-antibody...
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C8034 Anti-Clathrin antibody produced in goat whole antiserum
species reactivity, human. application(s), indirect immunofluorescence: 1:20 using human foreskin fibroblasts. Gene Information, human ... CLTC(1213) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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