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CCR2


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Symbol:CCR2
Name(s):chemokine (C-C motif) receptor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:CC-CKR-2, CCR2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18186797 There was no difference in the incidence of rejection among renal transplant recipients stratified by the CCR2-V64I genotype.
18197127 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18306985 Observational study of gene-disease association. (HuGE Navigator)
18332000 Observational study of genotype prevalence. (HuGE Navigator)
17426779 In this review we focus on the known polymorphisms of two chemokines: CCL2, CCL5 and their corresponding receptors (CCR2, CCR5) and we also discuss their associations with susceptibility and progression to selected immune-mediated diseases. [REVIEW]
17917677 preliminary evidence linking genetic variation in CCR2 to circulating levels of MCP-1
12403355 Observational study of gene-disease association. (HuGE Navigator)
12426226 Observational study of gene-disease association. (HuGE Navigator)
12436194 Observational study of genotype prevalence. (HuGE Navigator)
12447757 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBeta arrestin 1chemokine receptor 2 isoform A--Pubmed
HPRDarrestin beta 1 isoform ACC chemokine receptor 2--Pubmed
HPRDCC chemokine receptor 2monocyte chemoattractant protein--Pubmed
HPRDCC chemokine receptor 2small inducible cytokine A2 precursor--Pubmed
HPRDCC chemokine receptor 2small inducible cytokine A11 precursor--Pubmed
HPRDCC chemokine receptor 2small inducible cytokine A16 precursor--Pubmed
HPRDCC chemokine receptor 2Janus kinase 2--Pubmed
HPRDCC chemokine receptor 2small inducible cytokine A13 precursor--Pubmed
HPRDCC chemokine receptor 2small inducible cytokine A8 precursor--Pubmed
HPRDchemokine receptor 2 isoform AMonocyte chemotactic protein 3--Pubmed

Recent Publications on CCR2:

Pubmed Logo
CCR2 receptor ligands inhibit Cav3.2 T-type calcium channels.
Monocyte chemoattractant protein-1 (MCP-1) is a cytokine known to be...
30th October, 2009
University of Calgary. Mol Pharmacol. 2009 Oct 28.
DOI Direct Link
A distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated Plasmodium falciparum malaria.
Monocyte (MO) subpopulations display distinct phenotypes and functions...
24th October, 2009
Bio-medical Parasitology Unit, Institut Pasteur, Paris, France. PLoS Pathog. 2009 Oct;5(10):e1000631. Epub 2009 Oct 23.
DOI Direct Link
FROUNT Is a Common Regulator of CCR2 and CCR5 Signaling to Control Directional Migration.
FROUNT is a known CCR2-binding protein that facilitates...
21st October, 2009
*Department of Molecular Preventive Medicine, Graduate School of Medicine, J Immunol. 2009 Oct 19.
DOI Direct Link
Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria.
Host responses controlling blood stage malaria include both innate and...
20th October, 2009
MRC National Institute for Medical Research, United Kingdom; Blood. 2009 Oct 16.
DOI Direct Link
CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) mice.
OBJECTIVE: The CCR2 receptor plays a crucial role in monocyte recruitment...
20th October, 2009
Pfizer Global Research and Development, Department of Cardiovascular and Atherosclerosis. 2009 Aug 19.
DOI Direct Link

View more research publications.

Press Releases on CCR2:

BioPortfolio Logo
ChemoCentryx Reports Positive PROTECT-1 Study Results for Traficet-EN(TM) at the GASTRO 2009 UEGW/WCOG Conference 25th November, 2009 ChemoCentryx, Inc.

MOUNTAIN VIEW, Calif., Nov. 25 /PRNewswire/ -- ChemoCentryx, Inc., announced today that Phase II/III clinical data from the Company's PROTECT-1 (the Prospective Randomized

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference 1st June, 2009 ChemoCentryx, Inc.

Oral CCR9 Antagonist Demonstrates Clinical Efficacy with Favorable Tolerability Profile

MOUNTAIN VIEW, Calif., June 1 /PRNewswire/ -- ChemoCentryx, Inc., announced

ChemoCentryx's Traficet-EN(TM) Phase II/III Induction Phase Data in Crohn's Disease to be Featured in Oral Presentation at 2009 Digestive Disease Week 19th May, 2009 ChemoCentryx, Inc.

First-in-class Oral Therapeutic for IBD with Novel Mode of Action

MOUNTAIN VIEW, Calif., May 19 /PRNewswire/ -- ChemoCentryx, Inc., today announced that data from

ChemoCentryx Identifies Novel Small Molecule C5aR Antagonist 5th May, 2009 ChemoCentryx, Inc.

Development Candidate Triggers Milestone Payment from GlaxoSmithKline

MOUNTAIN VIEW, Calif., May 5 /PRNewswire/ -- ChemoCentryx, Inc.,

Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy 14th April, 2009 Osprey Pharmaceuticals U.S.A., Inc.

Trial to Evaluate Safety of CCL2-LPM for Inflammatory Kidney Disease

SAN FRANCISCO, April 14 /PRNewswire/ -- Osprey Pharmaceuticals U.S.A., Inc. announced today that patient

BioNews Results for CCR2

: RSS Logo
BioPortfolio Logo
Epigallocatechin gallate reduces human monocyte mobility and adhesion in vitro
Laboratory Investigation:  Nov 13 2009 8:31PM Matching: ccr2

Clinical Trials:

Clinical Trials Logo
Proof of Confidence Study of CCR2 Antagonist (BMS-741672) in Insulin Resistance

Patents:

Patents logo
US Patent No.Title
7557120 Aminocyclopentyl fused heterotricylicamide modulators of chemokine receptor activity
7572576 Method of predicting genetic risk for hypertension
7572600 Enzymatic activities in chemokine-mediated inflammation
7572813 Cyclic derivatives as modulators of chemokine receptor activity
7572953 Plants with delayed flowering

View more patents.

CCR2 results (if any) from reagent suppliers

Google CSE Logo
CCR2 antibody (ab25788) | Abcam
Goat polyclonal to CCR2. CCR2, or CC chemokine receptor type 2, is a receptor for several monocyte chemo attractant proteins (MCP1, MCP3, ...
http://www.abcam.com/CCR2-antibody-ab25788.html...

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CCR2 monoclonal antibody (M01A)
CCR2 (-, 1 a.a. ~ 43 a.a) partial recombinant protein with GST tag. ... CCR2 monoclonal antibody (M01A), clone 4D12 Western Blot analysis of CCR2 expression
...
http://www.abgent.com/products/catalog_no/AT1425a_CCR2_monoc...

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The Abcam catalog
CCR2 antibodies. ... CCR2 antibody [E68]. Flow Cyt, ICC, IP, WB, IHC-P. Images · Customer Abreviews: 3 stars (out of 5). Rabbit monoclonal ...
http://www.abcam.com/index.html?t=8515&pt=1&c=480...

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Anti-CCR2 Polyclonal Antibody
Polyclonal Antibody against CCR2 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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CCR2 antibody (ab21667) | Abcam
See below for CCR2 antibody images, references, products related to ab21667 and other tools. ... ab21667 staining CCR2 in human kidney tissue sections by ...
http://www.abcam.com/CCR2-antibody-ab21667.html...

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Mouse CCR2 Capralogics
capralogics, CCR2 polyclonal, goat anti mouse CCR2, murine CCR2 antibody, chemokine receptor type 2, anti-CCR2.
http://www.capralogics.com/CIO153.htm...

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PerCP/Cy55 Anti-human CD192 CCR2 Antibody Anti-CD192 - BioLegend
PerCP/Cy55 Anti-human CD192 CCR2 Antibody Anti-CD192 - CCR2 is a chemokine receptor that binds monocyte chemoattractant proteins (MCP-1, 2, 3 and 4).
http://www.biolegend.com/percp-cy55-anti-human-cd192-ccr2-an...

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