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CCR5


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Gene DB Home
Symbol:CCR5
Name(s):chemokine (C-C motif) receptor 5
Type:protein-coding
Organism:Homo sapiens
Synonyms:CC-CKR-5, CCCKR5, CD195, CKR-5, CKR5, CMKBR5
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18197127 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18205260 Observational study of gene-disease association. (HuGE Navigator)
18255039 Observational study of gene-disease association. (HuGE Navigator)
18311470 Observational study of gene-disease association. (HuGE Navigator)
18361062 Observational study of gene-disease association. (HuGE Navigator)
17426779 In this review we focus on the known polymorphisms of two chemokines: CCL2, CCL5 and their corresponding receptors (CCR2, CCR5) and we also discuss their associations with susceptibility and progression to selected immune-mediated diseases. [REVIEW]
16314800 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15331395 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
10985308 Observational study of gene-disease association. (HuGE Navigator)
11023492 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-fetoprotein precursorchemokine receptor 5--Pubmed
HPRDalpha-fetoprotein precursorchemokine receptor 5--Pubmed
HPRDarrestin beta 1 isoform Achemokine receptor 5--Pubmed
HPRDarrestin beta 1 isoform Achemokine receptor 5--Pubmed
HPRDCD4 antigen precursorchemokine receptor 5--Pubmed
HPRDCD4 antigen precursorchemokine receptor 5--Pubmed
HPRDchemokine receptor 2 isoform Achemokine receptor 5--Pubmed
HPRDchemokine receptor 2 isoform Achemokine receptor 5--Pubmed
HPRDCC chemokine receptor 5monocyte chemoattractant protein--Pubmed
HPRDCC chemokine receptor 5small inducible cytokine A2 precursor--Pubmed

Recent Publications on CCR5:

Pubmed Logo
Autoantibodies to the delta-opioid receptor function as opioid agonists and display immunomodulatory activity.
In this report, we show that affinity purified human anti-delta opioid...
3rd November, 2009
Department of Immunobiology, University of Arizona, 1656 E. Mabel Street, J Neuroimmunol. 2009 Oct 29.
DOI Direct Link
In vitro synergistic activity against CCR5-tropic HIV-1 with combinations of potential candidate microbicide molecules HHA, KRV2110 and enfuvirtide (T20).
Objectives To block the different mechanisms of HIV mucosal transmission,...
31st October, 2009
Universite Paris Descartes (Paris V), and Laboratoire de Virologie, J Antimicrob Chemother. 2009 Oct 29.
DOI Direct Link
Common CCR 5 polymorphism in stroke: the CCR 5 delta32 polymorphism differentiates cardioembolism from other aetiologies of ischaemic cerebrovascular diseases.
Inflammation is involved in the development of atherosclerosis. The CC...
31st October, 2009
Department of Neurology, Neuro-Angiological Research Center, Karolinska Scand J Immunol. 2009 Nov;70(5):475-80.
DOI Direct Link
Response to Vicriviroc in Treatment-Experienced Subjects, as Determined by an Enhanced-Sensitivity Coreceptor Tropism Assay: Reanalysis of AIDS Clinical Trials Group A5211.
The enhanced-sensitivity Trofile assay (Monogram Biosciences) was used to...
31st October, 2009
Harvard School of Public Health, 2Brigham and Women's Hospital, Harvard J Infect Dis. 2009 Oct 29.
DOI Direct Link
Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin alpha4beta7.
BACKGROUND:: The Step Study was a randomized trial to reduce HIV infection...
30th October, 2009
aCR UK Centre, School of Cancer Sciences, UK bSchool of Immunity and AIDS. 2009 Oct 27.
DOI Direct Link

View more research publications.

Press Releases on CCR5:

BioPortfolio Logo
Sangamo BioSciences Research Collaborators Awarded Grant From California Institute for Regenerative Medicine to Develop Zinc Finger Nuclease-Based Stem Cell Therapy for HIV/AIDS 28th October, 2009 Sangamo BioSciences, Inc.

RICHMOND, Calif. Oct. 28 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that the California Institute for Regenerative Medicine (CIRM) has

Schering-Plough Reports Financial Results for 2009 Third Quarter 22nd October, 2009 Schering-Plough Corporation
-- New product launches in Japan, the world's second largest pharmaceutical market, including ASMANEX (mometasone furoate) for asthma and REMERON (mirtazapine) for major
New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance 12th June, 2009 Quest Diagnostics Incorporated

Faster reporting aids physicians in identifying HIV mutations that can inhibit effectiveness of newest class of antiretroviral therapy

MADISON, N.J., June 12 /PRNewswire-FirstCall/ -

Sales of Antiretroviral Agents Will Drive Substantial Six Percent Annual Growth in the HIV Drug Market Through 2013 19th May, 2009 Decision Resources

By 2018, Gilead's Quad Will Become the Highest-Selling Antiretroviral in the World's Major Markets, According to a New Report from Decision Resources

Sangamo BioSciences Receives $100,000 Grand Challenges Explorations Grant for Innovative Global Health Research 4th May, 2009 Sangamo BioSciences, Inc.

RICHMOND, Calif., May 4 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO), the world leader in the research and development of zinc finger DNA-binding proteins (ZFPs),

BioNews Results for CCR5

: RSS Logo
BioPortfolio Logo
Vicriviroc: a CCR5 antagonist for treatment-experienced patients with HIV-1 infection
MDLinx:  Nov 12 2009 11:17AM Matching: ccr5
Pfizer/GSK HIV Spin-Off ViiV Healthcare Debuts With Personalized Drugs in Portfolio
GenomeWeb:  Nov 12 2009 8:04AM Matching: ccr5
Pfizer/GSK HIV Spin-Off ViiV Healthcare Debuts With Top Personalized Drugs in Portfolio
GenomeWeb:  Nov 11 2009 10:32PM Matching: ccr5
GSK and Pfizer launch joint HIV venture, ViiV Healthcare
Aidsmap:  Nov 4 2009 11:17AM Matching: ccr5
Sangamo BioSciences awarded a grant to develop zinc finger nuclease-based stem cell therapy for AIDS
News-Medical.Net:  Oct 29 2009 8:31AM Matching: ccr5
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Safety and Efficacy of an Antibody to CCR5 in Individuals With HIV Who Are Not Currently on Antiretroviral Therapy

Patents:

Patents logo
US Patent No.Title
7582416 Ligand for G-protein coupled receptor FPRL2 and uses thereof
7589204 Indane compounds as CCR5 antagonists
7589207 Cyclohexyl compounds as CCR5 antagonists
7592008 Membrane scaffold proteins
7592010 Albumin fusion proteins

View more patents.

CCR5 results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
CCR5 antibodies. ... CCR5 antibody - Carboxyterminal end. WB, ELISA. Rabbit polyclonal ... CCR5 antibody [HEK/1/85a] (Biotin). Flow Cyt. Rat monoclonal ...
http://www.abcam.com/index.html?t=8517&pt=1&c=641...

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CCR5 Antibody (NT) HIV & chemokine receptor
CCR5 antibody can be used for Western blot at 1:1000 to 1:2000 dilution. An approximate 40 kDa band can be detected. CCR5 antibody can also detect CCR5 by
...
http://www.prosci-inc.com/shop/catalog1/CCR5-Antibody-p-6007...

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CCR5 antibody (ab1673) | Abcam
Goat polyclonal to CCR5. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure of a 7 ...
http://www.abcam.com/CCR5-antibody-ab1673.html...

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PE Anti-mouse CD195 CCR5 Antibody Anti-CD195 - BioLegend
PE Anti-mouse CD195 CCR5 Antibody Anti-CD195 - CD195 is a 45 kD chemokine receptor also known as CCR5.
http://www.biolegend.com/pe-anti-mouse-cd195-ccr5-antibody-1...

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human CD195 antibody, Biotin conjugate
Human CCR5 is expressed on resting T cells with a memory/effector phenotype, ... CCR5 functions as a receptor to direct the chemotaxis of lymphocytes, ...
http://www.ebioscience.com/ebioscience/specs/antibody_13/13-...

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Alexa Fluor 700 Anti-human CD195 CCR5 Antibody Anti-CD195 - BioLegend
Alexa Fluor 700 Anti-human CD195 CCR5 Antibody Anti-CD195 - CD195, also known as CCR5, is a 45 kD G protein-coupled seven transmembrane CC-chemokine ...
http://www.biolegend.com/alexa-fluor-700-anti-human-cd195-cc...

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CCR5 antibody [HEK/1/85a] (ab11464) | Abcam
Rat monoclonal [HEK/1/85a] to CCR5. The CC chemokine receptor 5 (CCR5) is a member of the CC-chemokine receptor family, and has the characteristic structure
...
http://www.abcam.com/CCR5-antibody-HEK-1-85a-ab11464.html...

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