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COL2A1


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Symbol:COL2A1
Name(s):collagen, type II, alpha 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:ANFH, AOM, COL11A3, MGC131516, SEDC
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17683641 Prostaglandin E2 at lower levels than in inflammation suppress collagenase-mediated COL2A1 cleavage in osteoarthritic cartilage.
18177466 Sequence analysis revealed in the three patients a novel COL2A1 mutation (c.1468_1475delinsT) that accounted for a STL syndrome type I phenotype. One patient carries an EYA1 mutation, p.R328X, which was not present in the two other patients.
18040638 mRNAs for type II collagen and aggrecan were expressed by MSCs treated with either TGFbeta1 or OP-1; however, substantial matrix production was not induced.
12096843 Observational study of gene-disease association. (HuGE Navigator)
12360016 Observational study of gene-disease association. (HuGE Navigator)
15082485 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15922184 Observational study of gene-disease association. (HuGE Navigator)
16133074 Observational study of gene-disease association. (HuGE Navigator)
16978902 Observational study of genotype prevalence. (HuGE Navigator)
17195216 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAnnexin AValpha 1 type II collagen isoform 1--Pubmed
HPRDAnnexin Valpha 1 type II collagen isoform 1--Pubmed
HPRDannexin 5Collagen, type II, alpha 1--Pubmed
HPRDBiglycanalpha 1 type II collagen isoform 1--Pubmed
HPRDbone morphogenetic protein 2 preproproteinalpha 1 type II collagen isoform 1--Pubmed
HPRDbone morphogenetic protein 2 preproproteinalpha 1 type II collagen isoform 1--Pubmed
HPRDcomplement component 1, q subcomponent, A chain precursoralpha 1 type II collagen isoform 1--Pubmed
HPRDcomplement component 1, q subcomponent, A chain precursoralpha 1 type II collagen isoform 1--Pubmed
HPRDDiscoidin domain receptoralpha 1 type II collagen isoform 1--Pubmed
HPRDchondroadherin precursoralpha 1 type II collagen isoform 1--Pubmed

Recent Publications on COL2A1:

Pubmed Logo
Cloning and characterization of human vitreous tissue-derived cells.
Abstract. Purpose: Previously, we established a porcine vitreous...
3rd November, 2009
Department of Ocular Cellar Engineering, Yamagata University Hospital, Acta Ophthalmol. 2009 Oct 30.
DOI Direct Link
Screening of chondrogenic factors with a real-time fluorescence-monitoring cell line ATDC5-C2ER: Identification of sorting nexin 19 as a novel factor.
OBJECTIVE: To establish a cell culture system for noninvasive and...
31st October, 2009
Faculty of Medicine, University of Tokyo, Tokyo, Japan. Arthritis Rheum. 2009 Oct 29;60(11):3314-3323.
DOI Direct Link
Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.
During musculoskeletal development, Sry-type HMG box 9 (Sox9) has a...
16th October, 2009
Department of Orthopaedic Surgery, Science of Functional Recovery and Int J Biochem Cell Biol. 2009 Oct 12.
DOI Direct Link
Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses.
The objective of this study was to determine the primary articular tissue...
9th October, 2009
Department of Clinical Sciences, Cornell University, VMC C3-181, Ithaca, J Orthop Res. 2009 Oct 7.
DOI Direct Link
The Effects of ERK1/2 Inhibitor on the Chondrogenesis From Bone Marrow- and Adipose Tissue-derived Multipotent Mesenchymal Stromal Cells.
This study tested the hypothesis that mitogen-activated protein kinase...
8th October, 2009
Dongguk University International Hospital, Orthopaedics, Goyang, Korea, Tissue Eng Part A. 2009 Oct 6.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Molecular Genetic Study of Avascular Necrosis of the Femoral Head

Patents:

Patents logo
US Patent No.Title
6413742 Recombinant gelatin and full-length triple helical collagen
6696259 Assays using glial cell line-derived neurotrophic factor receptors
6706867 DNA array sequence selection
6759525 Protein kinase A and carney complex
6790658 Polynucleotide encoding a polypeptide having heparanase activity and expression of same in genetically modified cells

View more patents.

COL2A1 results (if any) from reagent suppliers

Google CSE Logo
COL2A1 (M2193) Antibody sc-52658
COL2A1 shRNA (h) Lentiviral Particles, sc-35081-V, 200 µl ... Western blot analysis of COL2A1 expression in CCD-1064Sk whole cell lysate. ...
http://www.scbt.com/datasheet-52658-col2a1-m2193-antibody.ht...

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COL2A1 antibody, Rabbit A' Bovine Collagen II Antibody, Rabbit ...
Buy quality rabbit COL2A1 antibody (interacts with n/a), anti-COL2A1, Rabbit A' Bovine Collagen II antibody, rabbit polyclonal antibody, Rabbit A' Bovine ...
http://www.genwaybio.com/product_info.php?products_id=244590...

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COL2A1 (N-19) Antibody sc-7764
See how others have used COL2A1 (N-19): sc-7764 antibody and or COL2A1 (N-19) ... Western blot analysis of COL2A1 expression in HISM whole cell lysate. ...
http://www.scbt.com/datasheet-7764-col2a1-n-19-antibody.html...

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COL2A1 Antibody (C-term)
COL2A1 Antibody (C-term) Cell Function, COL2A1 Antibody (C-term) Stem Cell, COL2A1 Antibody (C-term) Cell Structure.
http://www.abgent.com/products/catalog_no/AP1418b...

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COL2A1 (C-19) Antibody sc-7763
COL2A1 shRNA (h) Lentiviral Particles, sc-35081-V, 200 µl ... See how others have used COL2A1 (C-19): sc-7763 antibody and or COL2A1 (C-19) antibody ...
http://www.scbt.com/datasheet-7763-col2a1-c-19-antibody.html...

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Specification Sheet
Product Name, Monoclonal Anti-COL2A1 antibody produced in mouse, ... Sandwich ELISA, Detection limit for recombinant GST tagged COL2A1 is approximately ...
http://www.sigmaaldrich.com/catalog/DataSheetPage.do?brandKe...

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COL2A1 (CIIC1) Antibody sc-52657
COL2A1 (CIIC1) Antibody sc-52657 COL2A1 (CIIC1) Antibody sc-52657. ... COL2A1 shRNA (m) Lentiviral Particles, sc-35082-V, 200 µl ...
http://www.scbt.com/datasheet-52657-col2a1-ciic1-antibody.ht...

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