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COMT


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Gene DB Home
Symbol:COMT
Name(s):catechol-O-methyltransferase
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17962094 COMT val158met polymorphism is associated with life time fracture prevalence in elderly Swedish men
17525974 catechol-O-methyltransferase (Val158Met) polymorphism moderates affective and psychotic responses to stress in patients with psychosis, providing evidence for gene-environment interaction mechanisms in the formation of psychotic symptoms.
18194840 Observational study of gene-disease association. (HuGE Navigator)
18197080 Observational study of gene-disease association. (HuGE Navigator)
18198266 Observational study of gene-disease association. (HuGE Navigator)
18199630 Observational study of gene-disease association. (HuGE Navigator)
18201871 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18213617 Observational study of gene-disease association. (HuGE Navigator)
18214863 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18214865 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCatechol-O-methyltransferaseangiotensin I converting enzyme isoform 1 precursor--Pubmed
HPRDcatechol-O-methyltransferase isoform MB-COMTAngiotensin I converting enzyme--Pubmed
HPRDcatechol-O-methyltransferase isoform MB-COMT5'-3' exoribonuclease 2--Pubmed
HPRDcatechol-O-methyltransferase isoform MB-COMT5'-3' exoribonuclease 2--Pubmed

Recent Publications on COMT:

Pubmed Logo
Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality.
Schizophrenia is a multifactorial disorder characterized by the...
3rd November, 2009
Department of Genetic Epidemiology, SNP Genetics, Seoul, Republic of J Hum Genet. 2009 Oct 30.
DOI Direct Link
Entacapone, a catechol-O-methyltransferase inhibitor, improves the motor activity and dopamine content of basal ganglia in a rat model of Parkinson's disease induced by Japanese encephalitis virus.
Levodopa is the main medication used for the treatment of Parkinson's...
3rd November, 2009
Department of Molecular Biosciences, School of Pharmaceutical Sciences, Brain Res. 2009 Oct 28.
DOI Direct Link
Possible Risk Modification by Polymorphisms of Estrogen Metabolizing Genes in Familial Breast Cancer Susceptibility in an Indian Population.
ABSTRACT This case control study investigated whether polymorphisms of...
30th October, 2009
Regional Cancer Centre, Division of Cancer Research, Medical College Post, Cancer Invest. 2009 Oct 28.
A Candidate Gene Analysis of Methylphenidate Response in Attention-Deficit/Hyperactivity Disorder.
OBJECTIVE:: This study examines the potential role of candidate genes in...
28th October, 2009
Drs. McGough, McCracken, and Suddath are with the Semel Institute for J Am Acad Child Adolesc Psychiatry. 2009 Oct 23.
DOI Direct Link
The association of catechol-O-methyltransferase genotype with the phenotype of women with eating disorders.
Objective: The modern brain imaging studies in patients with eating...
27th October, 2009
Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26; Brain Res. 2009 Oct 21.
DOI Direct Link

View more research publications.

Press Releases on COMT:

BioPortfolio Logo
Reportlinker Adds Alzheimer's and Parkinson's Diseases - A Global Update of Market Trends & Opportunities 18th November, 2009 Reportlinker

NEW YORK, Nov. 18 /PRNewswire/ --

Reportlinker.com announces that a new market research report is available in its catalogue.

Merck Serono Initiates SETTLE, the Second Phase III Clinical Trial of Safinamide in Advanced Parkinson's Disease

7th May, 2009

GENEVA, Switzerland, May 7 /PRNewswire/ -- Merck Serono, a division of Merck KGaA, Darmstadt, Germany, and its partner Newron Pharmaceuticals SpA (SWX: NWRN) announced today the initiation of the

Merck Serono's Safinamide Significantly Improved Motor Function in Patients With Advanced Parkinson's Disease in a Phase III Pivotal Trial 3rd February, 2009

GENEVA, Switzerland, February 3 /PRNewswire/ -- Merck Serono, a division of Merck KGaA, Darmstadt, Germany, and its partner Newron Pharmaceuticals SpA (SWX: NWRN) announced today that the first

CeNeS and Tripos Announce Advances in COMT inhibitor discovery programme 1st December, 2004 Cenes

CeNeS and Tripos Announce Advances in COMT inhibitor discovery programme

Improving levodopa-based complications to advance Parkinson's Disease 1st January, 1970 Dailyupdates

Improving levodopa

BioNews Results for COMT

: RSS Logo
BioPortfolio Logo
Hearing loss in chemo kids has genetic link
CBC:  Nov 9 2009 7:32PM Matching: comt
Album: Rickie Lee Jones, Balm in Gilead, (Fantasy)
The Independent:  Nov 1 2009 11:24AM Matching: comt
Association analysis of COMT polymorphisms with schizophrenia and smooth pursuit eye movement abnormality
International Journal of Impotence Research:  Oct 30 2009 7:24PM Matching: comt
The protein for quick decision-making
Research & Development:  Oct 27 2009 3:02PM Matching: comt
PERSISTENT POSTSURGICAL PAIN: IS IT IN YOUR GENES?
Newswise:  Oct 24 2009 9:40PM Matching: comt
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Relation of Catechol-O-Methyltransferase (COMT) Genotype and Response to Cognitive Remediation Schizophrenia

Patents:

Patents logo
US Patent No.Title
7452893 4-cycloakylaminopyrazolo pyrimidine NMDA/NR2B antagonists
7507841 Cannabinoid receptor modulator
7507875 Transcription factors
7510881 Method and kit for the quantitative and/or qualitative detection of components in a sample
7514251 O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in Papaver somniferum

View more patents.

COMT results (if any) from reagent suppliers

Google CSE Logo
COMT antibody (ab51984) | Abcam
Goat polyclonal to COMT. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the ...
http://www.abcam.com/COMT-antibody-ab51984.html...

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COMT Antibody / COMT Antibodies
COMT Antibody / COMT Antibodies. ... COMT specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-comt.html...

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C6870 Anti-COMT antibody produced in rabbit IgG fraction of ...
C6870 Anti-COMT antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...

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COMT (FL-271) Antibody sc-25844
See how others have used COMT (FL-271): sc-25844 antibody and or COMT (FL-271) ... Western blot analysis of COMT expression in IMR-32 whole cell lysate. ...
http://www.scbt.com/datasheet-25844-comt-fl-271-antibody.htm...

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COMT antibodies: Neuroscience > Neurology process ...
COMT antibodies. ... COMT antibody. WB. Mouse polyclonal. Reacts with: Hu. ab51984 · COMT antibody. WB, ELISA. Images. Goat polyclonal. Reacts with: ...
http://www.abcam.com/index.html?t=154562&pt=1&c=429&ei=&mu=r...

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Anti-COMT (N-terminal) (C6995) - Data Sheet
Anti-COMT (N-terminal) is produced in rabbit using as immunogen a synthetic peptide ... diseases.1, 4 COMT inhibitors are important therapeutic ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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COMT (FL-271) Antibody sc-25844
COMT shRNA (h) Lentiviral Particles, sc-43693-V, 200 µl ... COMT (FL-271): sc- 25844. Western blot analysis of COMT expression in IMR-32 whole cell lysate. ...
http://www.scbt.com/ko/datasheet-25844-comt-fl-271-antibody....

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