Gene Information from Publications |
| Publication Link |
Summary of findings |
| 11463752 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12753312 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16097366 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16609682 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17922433 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17941085 |
These data show that ADM acts as a survival factor in osteoblastic cells via a CGRP1 receptor-MEK-ERK pathway, which provides further understanding on the physiological function of ADM in osteoblasts. |
| 18080871 |
Depending on the clinical severity of the infection, both CT-proET-1 and MR-proADM levels exhibited a gradual increase from Systemic Inflammatory Response Syndrome (SIRS) to sepsis and septic shock. |
| 17766467 |
In conclusion, ADM exerts Ca(2+)-dependent positive inotropic effects in human atrial and less-pronounced effects in ventricular myocardium. |
| 18000597 |
possesses several protective cardiovascular qualities, including protection of the microcirculation during inflammation, and was proven as an efficient counter-regulatory molecule in various models of sepsis and septic shock. |
| 17952853 |
Adrenomedullin (ADM) expression in the anterior pituitary is diminished in tumors as compared to the normal gland. |
| 15917349 |
ADM may be involved in the human implantation process via regulating trophoblast proliferation and differentiation |
| 11972292 |
the heart and the lungs release adrenomedullin peptides in moderate congestive heart failure and this secretion breaks down in severe CHF |
| 14517225 |
Adrenomedullin production is decreased in preeclampsia. |
| 12565880 |
ratio of mature AM/total AM was significantly decreased in the fetal membranes of the patients with chorioamnionitis compared with normal pregnancies, but not in the placenta; results suggested that mature AM may have some role in chorioamnionitis |
| 14720432 |
Hybridization in situ showed that ADM mRNA expression was significantly higher in pulmonary artery walls in patients with chronic obstructive pulmonary disease(COPD) and ADM may play an important protective role in the development of COPD. |
| 11744163 |
Adrenomedullin increases cycl AMP through amylin and CGRP1 receptors. |
| 16596251 |
Findings provide evidence that at least a subset of cardiac mast cells are able to synthesize and store adrenomedullin. |
| 16963041 |
Adrenomedullin may play a role in regulating the insulin metabolism in patients with PCOS. |
| 16221100 |
Adrenomedullin, a smooth muscle relaxant peptide that is synthesized in urinary tract tissue might have a role in acute pyelonephritis |
| 12720100 |
The expression of adrenomedullin in invasive squamous cell carcinoma of the cervix may crucial role in promoting carcinoma progression. |
| 12782295 |
AM plays significant roles in vascular regeneration, associated with PKA- and PI3K-dependent activation of Akt in endothelial cells, and possesses therapeutic potential for vascular injury and tissue ischemia |
| 16416151 |
We conclude that long-term water submersion has endocrine as well as plasma volume effects that are opposite to those seen after short-term immersion, and which increases plasma adrenomedullin. |
| 12920627 |
Adrenomedullin and nitrates may have a role in immunoinflammatory process of Henoch-Schonlein purpura, especially in active stage, although whether this perpetuates, or protects against, further vascular injury is not clear. |
| 11921362 |
role in carcinogenesis - review |
| 11921363 |
role in the inflammatory response - review |
| 15788445 |
described for the first time that adrenomedullin down-regulates lipolysis in adipocytes through the chemical modification of a beta-agonist |
| 16622024 |
ADM may prevent or reduce rheumatoid arthritis-fibroblast-like synoviocyte apoptosis, via up-regulation of its functional receptor calcitonin receptor-like receptor/receptor activity-modifying protein-2 |
| 12687457 |
AM levels were increased in bladder in children with detrusor instability |
| 12660258 |
Increase in AM expression in endometrium may be responsible for frequent occurrence of irregular bleeding during initial 3 months of levonorgestrel-releasing intra-uterine system use. |
| 11905404 |
data show a reduction of adrenomedullin and CGRP mRNAs in placenta specimens of women with preeclampsia or HELLP syndrome |
| 12716843 |
Increased oxidative stress is associated with elevated blood adrenomedullin levels in hypertensive NIDDM patients. |
| 12805025 |
Adrenomedullin protects against myocardial infarction, arrhythmia, and apoptosis in ischemia and reperfusion injury via suppression of oxidative stress-induced Bax and p38 MAPK phosphorylation and activation of the Akt-Bad-Bcl-2 signaling pathway. |
| 17384335 |
Adrenomedullin might play a role in the pathogenesis of diabetic angiopathy. |
| 12684703 |
Data show that an endogenous adrenomedullin system promotes the growth of keratinocytes and fibroblasts cultured in vitro, by enhancing their proliferative activity and lowering their apoptotic deletion. |
| 14612905 |
Adrenomedullin peptide is widely expressed in breast cancer and that the degree of expression is associated with lymph node metastasis |
| 15974887 |
REVIEW: Cardiac adrenomedullin: its role in cardiac hypertrophy and heart failure |
| 14715486 |
AM was widely distributed in the human kidney with arterial stenosis. |
| 12566732 |
Novel correlation of adrenomedullin and aquaporin 2(AQP2) which overlays an AVP-AQP2 system may play a key role in fluid homeostasis during general anesthesia. |
| 15531734 |
Adrenomedullin is highly expressed in blood monocytes associated with acute Kawasaki disease |
| 15702240 |
endothelin 1 and AM markedly stimulated the growth of SW-13 cells |
| 15902095 |
findings indicate that glomerular production of adrenomedullin was decreased in patients with IgA nephropathy |
| 16356592 |
adrenomedullin has roles in neurotransmission and neuromodulation in the human medulla oblongata |
| 17022943 |
The present study has shown that AM expression is up-regulated during adipocyte differentiation of hMSCs probably via the interaction between Sp1 or Sp1-related factor(s) and the AM promoter region (-70/-29). |
| 17290391 |
ADM increases invasiveness of some pancreatic cancer cells and might influence angiogenesis |
| 17327422 |
The response of adrenomedullin to insulin via insulin responsive genetic elements is reported. |
| 12189226 |
Cells that overexpressed adrenomedullin displayed a more pleiotropic morphology, an increased angiogenic potential both in vitro and in vivo, and less apoptosis after serum deprivation. |
| 12601625 |
In patients with primary hyperparathyroidism, plasma adrenomedullin concentrations are increased and correlate with serum intact parathyroid hormone and blood pressure values. |
| 12763641 |
Adrenomedullin is increased after liver transplant with increased creatinine and atrial natriuretic peptide, suggesting a potential role for ADM in volume regulation after liver transplantation. |
| 15194870 |
ADM may be associated with the pathophysiology of schizophrenia |
| 15665526 |
up regulation of ICAM-1 in oral keratinocytes by Adrenomedullin |
| 15866060 |
Plasma levels correlate with inflammatory markers but not with endothelial dysfunction markers in Type 1 diabetic patients without atherosclerotic disease. |
| 16256216 |
results suggest that AM plays a role in the regulation of HASMC contraction by antagonizing the Ang II effects and may be involved in conditions of altered regulation of the blood vessels. |
| 16322067 |
Adrenomedullin regulates cellular glutathione content via modulation of gamma-glutamate-cysteine ligase catalytic subunit expression |
| 16815566 |
endothelin-1, but not adrenomedullin, has a role in pulmonary incremental resistance during low-dose dobutamine infusion |
| 12375542 |
concentrations of mature adrenomedullin were elevated in pregnant women compared with non-pregnant women and its concentration in the third trimester was significantly higher than that in the first trimester |
| 12835224 |
Transplantation of adrenomedullin gene-transduced endothelial progenitor cells [EPCs] caused greater improvement in pulmonary hypertension in MCT rats than transplantation of EPCs alone |
| 15192039 |
c-myc transactivates rat and human adrenomedullin genes and accelerates the degradation rate of adrenomedullin mRNA |
| 15789277 |
Hyperinsulinemia may, at least in part, regulate levels of adrenomedullin in obesity, explaining the high levels of the peptide in these subjects. |
| 15361766 |
Plasma mature-adrenomedullin showed significantly positive associations with carotid atherosclerosis and atherothrombotic ischemic stroke, independent of systolic blood pressure. |
| 15684700 |
ADM gene delivery protects against cerebral ischemic injury by promoting astrocyte migration and survival. |
| 12383875 |
Immunoreactive-AM levels in the aqueous humor were significantly elevated in patients with uveitis and vitroretinal disorders and may be involved in the physiopathology of the uveitis and some vitreoretinal disorders. |
| 14671210 |
In preeclampsia, regional increases in adrenomedullin mRNA may be induced by hypoxia and mediate local fetal/placental adaptive responses to reduced placental perfusion. |
| 14534081 |
Role for adrenomedullin and ACTH in the regulation of the immune and inflammatory response. |
| 15336545 |
AM (either overexpressed or exogenously added) causes an inhibition of prostate cancer cell growth. |
| 12324915 |
The mature form of adrenomedullin is pathophysiologically significant as a useful marker of circulating blood volume in hemodialysis patients. |
| 12220731 |
Release of this peptide into the blood is affected by exercise and altitude |
| 12753312 |
The microsatellite DNA polymorphism of AM gene may be associated with the genetic predisposition to develop nephropathy in Japanese patients with type 2 diabetes mellitus. |
| 16854513 |
We conclude that in human seminal fluid adrenomedullin concentration is increased in infertile oligozoospermic patients and derives very likely from the prostate. Its role in the regulation of male fertility, however has to be understood. |
| 11956648 |
The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review). |
| 12529288 |
Responses to CGRP and ADM are mediated by CGRP(8-37)-sensitive receptors and that the endothelial ADM receptor induces vasodilation by a nitric oxide-guanylyl cyclase mechanism, whereas a smooth muscle CGRP receptor signals by a cAMP-dependent mechanism |
| 11712085 |
Endogenous ADM system plays a potentially important role in the paracrine or autocrine functional control of Conn's adenomas. |
| 12376296 |
The changes of plasma ADM and PAMP concentrations at different stages of CHF indicate intramolecular regulation disturbances of vasodilator peptides of proadrenomedullin, and ADM may play a more important role in the development of CHF. |
| 12484513 |
plasma levels of AM, atrial natriuretic peptide(ANP)and brain natriuretic peptide (BNP)increased with aging; ANP and BNP increased in association with pulse pressure; possible relation between levels and age-related changes in cardiovascular system |
| 16797107 |
Our results suggest that AM plays a role in the regulation of HASMC growth antagonizing the AngII effect and may be involved in conditions of altered regulation of the blood vessels. |
| 12137974 |
Follicular fluid adrenomedullin concentrations in spontaneous and stimulated cycles are relationed to ovarian function and endothelin-1 and nitric oxide. |
| 12630817 |
adrenomedullin promotes proliferation and migration of vascular endothelial cells via a cAMP/PKA dependent pathway |
| 12630823 |
existence of the 19-repeat allele is associated with genetic predispositions to develop essential hypertension and diabetic nephropathy. |
| 12903912 |
Human adrenomedullin produced a significant decrease in rat heart contractile force and perfusion pressure, but only amylin fragment 8-37 caused a decline in heart rate at the highest dose. |
| 15242974 |
Recombinant human AM possesses novel angiogenic properties mediated by its ability to enhance VEGF expression and Akt activity in Am(+/-)knockout mice. |
| 15527794 |
adrenomedullin has been identified as a host defense peptide and as such it plays a role in the inflammatory response |
| 15761041 |
CGRP and ADM are two differentially regulated novel adipose tissue secretion factors exerting autocrine/paracrine roles. |
| 15908101 |
AM may contribute either in the penile erection and in the regulation of testicular function and sperm motility |
| 12193565 |
results indicate that adrenomedullin (AM) inhibits doxorubicin-induced cardiac myocyte apoptosis through a cAMP-dependent mechanism and suggest that augmented production of AM by doxorubicin has an endogenous antiapoptotic effect |
| 14714580 |
plasma adrenomedullin concentration could serve as a marker of advanced arterial sclerosis |
| 15544858 |
the high AM plasma levels in patients with severe lung disease are not caused by a reduced pulmonary clearance |
| 15758554 |
Ghrelin, as well as AM, may play an important role as vasodilator local hormones and regulation of blood pressure during hemodialysis, especially the occurrence of episodic hypotension. |
| 11774814 |
There were evident postburn changes in plasma adrenomedullin(ADM) contents, and the results implied that ADM played some roles in the development of postburn physiological disturbance. |
| 12579522 |
Data show that mean values of plasma total nitrite and adrenomedullin levels in the autistic children are significantly higher than control values. |
| 12646214 |
adrenomedullin has an autocrine/paracrine type of anti-proliferative effect via a cAMP-dependent pathway and may play a role in the local modulation of a process of de-differentiation by culturing chondrocyte phenotype cells |
| 16097366 |
possible mutation linked to the haplotype may indicate a genetic predisposition for proteinuria in essential hypertension |
| 16115629 |
These results suggest that in addition to reducing blood pressure, proadrenomedullin N-terminal 20 peptide suppresses cardiac hypertrophy through negative regulation of the local cardiac renin-angiotensin system. |
| 16609682 |
In Chinese, the ADM -1984G allele is associated with lower sodium excretion and in older subjects also with lower systolic pressure and narrower pulse pressure. |
| 16821090 |
PC12 and U251 cells overexpressing PTEN had decreases in adrenomedullin mRNA levels. Cellular and secreted adrenomedullin peptide was similarly reduced. U251 cells overexpressing PTEN did not respond to exogenous adrenomedullin. |
| 17053041 |
We find that certain conditions, such as pregnancy, cardiovascular disease, and sepsis, are associated with robust and dynamic changes in the expression of AM and AM receptor proteins. |
| 17584073 |
review describes the biochemistry, physiology, and circulating levels of AM--REVIEW |
| 12853384 |
Gastric epithelial cells exposed to inflammatory cytokines, Helicobacter pylori, E. coli, S. enterica, or Streptococcus bovis increased adrenomedullin expression & secretion. Epithelial infection, inflammation, & adrenomedullin expression are associated. |
| 12969589 |
adrenomedullin may be involved in both normal and malignant tissue growth and because of the correlations with estrogen receptor alpha and beta status, there is evidence that ovarian cancer is endocrine-related |
| 15016771 |
Both luteinized granulosa cells and macrophages actively secrete VEGF and adrenomedullin into follicular fluid in the human ovary. |
| 14759562 |
Plasma AM concentration was elevated in patients with peripheral arterial occlusive disease (PAOD) in proportion to the severity of the disease and associated with vascular inflammation |
| 15044509 |
Saliva from the submandibular and parotid glands contained higher concentrations of adrenomedullin than did the circulation, but lower concentrations than in whole saliva. Oral epithelium may contribute much of the adrenomedullin peptide found in saliva. |
| 15677761 |
adrenomedullin (ADM), a multifunctional neuropeptide, stimulates nitric oxide (NO) release by modulating intracellular free calcium concentration ([Ca2+]i) in neuron-like cells |
| 15711093 |
Adrenoleukodystrophy/adrenomyeloneuropathy(ALD/AMN) shows less compromised glomerular function, indicating that AM is not completely correlated with mineralocorticoid insufficiency. Mechanism of increased AM levels in ALD/AMN is still unknown. |
| 16517613 |
Adrenomedullin protein content and mRNA expression in human fetal membranes was increased in pre-eclampsia. |
| 17307261 |
Possible role of ADM in the regulation of Fontan circulation was studied. |
| 12643861 |
decreased levels of AMBP-1 play a critical role in producing vascular AM (adrenomedullin) hyporesponsiveness during the late stage of sepsis (AMBP-1) |
| 11879669 |
role in microvasculature - review |
