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ATF2


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Symbol:ATF2
Name(s):activating transcription factor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:CRE-BP1, CREB2, HB16, MGC111558, TREB7
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12270648 Observational study of gene-disease association. (HuGE Navigator)
18077426 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
17869487 ATF2/STAT3 signaling pathways are activated and may play a role in development of eccrine porocarcinoma and eccrine poroma.
17626013 ATF2, but not CREB, was a target for the TAK1-JNK pathway, and p38 negatively regulated TAK1 activity through TAB1 phosphorylation.
17681939 The transcription factor ATF2, which is phosphorylated and activated by JNK, is a critical mediator for inducible expression of DUSP1 and DUSP10 in this signaling pathway.
14630918 ATF4 and ATF2 have roles in regulating CHOP expression
12833146 ATF-2 and ATF3 seem to play an important role in the protective response of human cells to ionizing radiation
17082618 Binding of ATF2 to the CD1A promoter in human monocytes suggests a role for ATF/cAMP response element binding protein family members in regulation of CD1A expression.
16896160 gamma-gene induction by butyrate and trichostatin A involves ATF-2 and CREB1 activation via p38 MAPK signaling.
17054722 Sin1 may contribute to ATF-2 signaling specificity by acting as a nuclear scaffold.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BIND-activating transcription factor 2An unspecified isoform of ATM interacts with and phosphorylates ATF2.-Pubmed
HPRDC/EBP alphaactivating transcription factor 2--Pubmed
HPRDCCAAT/enhancer binding protein, alphaActivating transcription factor 2--Pubmed
HPRDCCAAT/Enhancer binding protein, betaactivating transcription factor 2--Pubmed
HPRDCCAAT/enhancer binding protein betaActivating transcription factor 2--Pubmed
HPRDActivating transcription factor 2retinoblastoma 1--Pubmed
HPRDActivating transcription factor 2jun oncogene--Pubmed
HPRDActivating transcription factor 2endothelial differentiation-related factor 1 isoform alpha--Pubmed
HPRDActivating transcription factor 2general transcription factor IIF, polypeptide 2, 30kDa--Pubmed
HPRDActivating transcription factor 2v-fos FBJ murine osteosarcoma viral oncogene homolog--Pubmed

Recent Publications on ATF2:

Pubmed Logo
Combinatorial transcription factor regulation of the cyclic AMP-response element on the Pgc-1alpha promoter in white 3T3-L1 and brown HIB-1B preadipocytes.
Cold stress in rodents increases the expression of UCP1 and PGC-1alpha in...
15th October, 2009
School of Biosciences, University of Nottingham, Sutton Bonington Campus, J Biol Chem. 2009 Jul 31;284(31):20738-52. Epub 2009 Jun 2.
DOI Direct Link
Identification of a novel amino acid response pathway triggering ATF2 phosphorylation in mammals.
It has been well established that amino acid availability can control gene...
14th October, 2009
Unite de Nutrition Humaine, UMR 1019, INRA de Theix, 63122 Saint Genes Mol Cell Biol. 2009 Oct 12.
DOI Direct Link
Using promoter replacement and selection for loss of heterozygosity to generate an industrially applicable sake yeast strain that homozygously overproduces isoamyl acetate.
By application of the high-efficiency loss of heterozygosity (HELOH)...
7th October, 2009
Research Institute, Gekkeikan Sake Co. Ltd., 101 Shimotoba-koyanagi-cho, J Biosci Bioeng. 2009 Nov;108(5):359-64.
DOI Direct Link
AP-1 activated by toll-like receptors regulates expression of IL-23 p19.
Interleukin (IL)-23, a new member of the IL-12 family, plays a central...
6th October, 2009
Immunology Institute, Mount Sinai School of Medicine, New York, New York J Biol Chem. 2009 Sep 4;284(36):24006-16. Epub 2009 Jul 10.
DOI Direct Link
The transcription factor Atf1 binds and activates the APC/C ubiquitin ligase in fission yeast.
Fission yeast Atf1 is a member of the ATF/CREB basic leucine zipper (bZIP)...
6th October, 2009
Cell Cycle Control Laboratory, Marie Curie Research Institute, The Chart, J Biol Chem. 2009 Sep 4;284(36):23989-94. Epub 2009 Jul 7.
DOI Direct Link

View more research publications.

BioNews Results for ATF2

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Melanoma Prognostic Model Using Tissue Microarrays and Genetic Algorithms [Melanoma]
Journal of Clinical Oncology:  Nov 4 2009 11:47AM Matching: atf2

Patents:

Patents logo
US Patent No.Title
7442534 Nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins
7494646 Antibodies and molecules derived therefrom that bind to STEAP-1 proteins
7501415 Selective inhibitors of ERK protein kinase and uses thereof
7501502 Nucleic acid and corresponding protein entitled 85P1B3 useful in treatment and detection of cancer
7507541 36P6D5: secreted tumor antigen

View more patents.

ATF2 results (if any) from reagent suppliers

Google CSE Logo
ATF2 antibody (ab809) | Abcam
Goat polyclonal to ATF2. ATF2 (Activating Transcription Factor 2, CREBP, HB16, CREB2, TREB7) is a member of the ATF/CREB family of basic region leucine ...
http://www.abcam.com/ATF2-antibody-ab809.html...

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Phospho-ATF-2 (Thr71) Antibody #9221
Phospho-ATF-2 (Thr71) Antibody detects endogenous levels of ATF-2 only when phosphorylated at threonine 71. This antibody does not cross-react with ...
http://www.cellsignal.com/products/9221.html...

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p-ATF-2 (Thr 71) Antibody sc-7982
See how others have used p-ATF-2 (Thr 71): sc-7982 antibody and or p-ATF-2 ... Western blot analysis of human recombinant ATF-2 untreated fusion protein (A ...
http://www.scbt.com/datasheet-7982-p-atf-2-thr-71-antibody.h...

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Phospho-ATF-2 (Thr71) Antibody
ATF-2 and Thr71 singly phosphorylated ATF-2 equally well. ... Thr71 of human ATF2. Antibodies are purified by protein A and peptide affinity chromatography.
...
http://www.cellsignal.com/pdf/9221.pdf...

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p-ATF-2 (F-1) Antibody sc-8398
See how others have used p-ATF-2 (F-1): sc-8398 antibody and or p-ATF-2 (F-1) antibody ... Western blot analysis of ATF-2 activation in untreated (A,C) and
...
http://www.scbt.com/datasheet-8398-p-atf-2-f-1-antibody.html...

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PhosphoPlus® ATF-2 (Thr71) Antibody Kit
ATF-2 by phosphorylation of Thr69 and Thr71 (2-4). Both. SAPK and p38 MAPK have been shown to .... ATF2 via a two-step mechanism: phosphorylation of Thr71 ...
http://www.cellsignal.com/pdf/9220.pdf...

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ATF-2 (C-19) Antibody sc-187
See how others have used ATF-2 (C-19): sc-187 antibody and or ATF-2 (C-19) ... Western blot analysis of ATF-2 expression in K-562 nuclear extracts (A,B). ...
http://www.scbt.com/datasheet-187-atf-2-c-19-antibody.html...

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