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CRH


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Gene DB Home
Symbol:CRH
Name(s):corticotropin releasing hormone
Type:protein-coding
Organism:Homo sapiens
Synonyms:CRF
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12734882 Observational study of gene-disease association. (HuGE Navigator)
14573312 Observational study of gene-disease association. (HuGE Navigator)
11140838 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
11555839 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
12051390 Observational study of gene-disease association. (HuGE Navigator)
12154211 Observational study of gene-disease association. (HuGE Navigator)
17676473 Network analysis showed that AA have retained an ancestral CRH haplotype, while the most common EA haplotype is derived from a single recombination event.
18212352 phorbol ester stimulates CRH gene transcriptional activity through the CRE, suggesting that cross-talk between PKC and protein kinase A signaling pathways targets this regulatory element in placental cells
17693031 Acute GES reduces the number of CRF-producing neurons and decreases CRF expression in PVN during post-operative gastric ileus.
17568667 findings suggest that CRH augments LPS induced cytokine secretion in human trophoblast cells. Modulation of LPS induced immune responses by CRH may be mediated through regulation of TLR-4 and selective activation of the p38/MAPK signalling pathway.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCorticotropin releasing hormoneHomo sapiens corticotropin releasing hormone receptor type 2 beta isoform mRNA, complete cds.--Pubmed
HPRDcorticotropin releasing hormone precursorCorticotropin releasing hormone receptor 2--Pubmed
HPRDcorticotropin releasing hormone precursorcorticotropin releasing hormone receptor 1--Pubmed
HPRDcorticotropin releasing hormone precursorcorticotropin releasing hormone receptor 1--Pubmed

Recent Publications on CRH:

Pubmed Logo
Urocortin modulates dopaminergic neuronal survival via inhibition of glycogen synthase kinase-3beta and histone deacetylase.
Urocortin (UCN) is a member of the corticotropin-releasing hormone (CRH)...
31st October, 2009
Department of Research, Neuro-Medical Scientific Center, Buddhist Tzu Chi Neurobiol Aging. 2009 Oct 27.
DOI Direct Link
Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Corticotropin-Releasing Hormone Promoter.
CRH is widely expressed in the brain and is of broad functional relevance...
27th October, 2009
Laboratory of Molecular Genetics and Howard Hughes Medical Institute Endocrinology. 2009 Oct 23.
DOI Direct Link
Corticotropin-releasing hormone attenuates vascular endothelial growth factor release from human HaCaT keratinocytes.
OBJECTIVES: Corticotropin-releasing hormone (CRH) is a central component...
27th October, 2009
Department of Dermatology, Qilu Hospital, Shandong University, Jinan Regul Pept. 2009 Oct 20.
DOI Direct Link
Concomitant Medication Use Can Confound Interpretation of the Combined Dexamethasone-Corticotropin Releasing Hormone Test in Cushing's Syndrome.
Context: The ability of combined dexamethasone-corticotropin releasing...
24th October, 2009
Neuroendocrine Clinical Center (E.V., L.B.N., D.A.D., A.K., B.M.K.B.), J Clin Endocrinol Metab. 2009 Oct 22.
DOI Direct Link
Evidence that Corticotropin-Releasing Hormone Modulates Myometrial Contractility during Human Pregnancy.
As human pregnancy advances, CRH increases exponentially and is...
23rd October, 2009
Mothers and Babies Research Centre, Hunter Medical Research Institute, The Endocrinology. 2009 Oct 21.
DOI Direct Link

View more research publications.

Press Releases on CRH:

BioPortfolio Logo
CRH Medical introduces non surgical hemorroid removal to Gastroenterology Fellowship program 29th June, 2009 CRH Medical Corporation

VANCOUVER, June 29 /PRNewswire-FirstCall/ - CRH Medical Corporation (CRM:TSX-V) announced today that the University of South Alabama College of Medicine in Mobile Alabama has completed a

CRH Medical reports Q1 2009 results 26th May, 2009 CRH Medical Corporation
    (all figures are in US dollars)

    -   Product sales revenue increases 510%
    -   Operating loss narrows significantly

VANCOUVER, May 26 /PRNewswire-FirstCall/ - CRH

CRH Medical reports year end results 30th April, 2009 CRH Medical Corporation
    (all figures are in US dollars)

    -   Clinic operations revenue increases 100%
    -   Product sales revenue increases 173%

VANCOUVER, April 30 /PRNewswire-FirstCall/ -

CRH O'Regan Hemorrhoid Banding system featured on a nationally syndicated television program 12th March, 2009 CRH Medical Corporation

VANCOUVER, March 12 /PRNewswire-FirstCall/ - CRH Medical Corporation (CRM:TSX-V) announced today that its proprietary CRH O'Regan Hemorrhoid Banding Technology will be featured on the

CRH Medical focuses on profitability in 2009 4th March, 2009 CRH Medical Corporation

VANCOUVER, March 4 /PRNewswire-FirstCall/ - CRH Medical Corporation (CRM:TSX-V) announced today that it has taken significant steps toward being cash flow positive in 2009.

The steps include

BioNews Results for CRH

: RSS Logo
BioPortfolio Logo
Elan and CRH keep Dublin market gains to a minimum
Irish Independent:  Nov 12 2009 9:13AM Matching: crh
CRH Drags on Iseq As Banks Get No Respite From Holiday
I Stock Analyst:  Oct 27 2009 8:43AM Matching: crh
Using his assets
Sunday Business Post:  Oct 25 2009 6:22PM Matching: crh
Consumer Reports Health News
KLFY:  Oct 20 2009 3:53PM Matching: crh
Consumer health news
Pharmacy Choice:  Oct 20 2009 8:08PM Matching: crh
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency

Patents:

Patents logo
US Patent No.Title
7485298 Diagnosis and treatment of human dormancy-related sequellae
7534763 Sustained release GLP-1 receptor modulators
7536453 Network traffic analyzer
7539601 Energy efficient air handling system for cleanrooms
7541481 Monocyclopentadienyl complex

View more patents.

CRH results (if any) from reagent suppliers

Google CSE Logo
CRH Antibody
(formalin-fixed paraffin-embedded) using CRH antibody. BUFFER: Antibody is supplied in 10 mM PBS, ... STORAGE: CRH antibody can be stored at 4慢 or -20慢.
...
http://www.prosci-inc.com/shop/pdf/51-101.pdf...

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CRH peptide, Corticotropin Releasing Factor Human Rat peptide
Buy quality CRH peptide (n/a), CRH, Corticotropin Releasing Factor Human Rat peptide, (n/an/a). Corticotropin-releasing factor; CRF; Corticotropin-releasing
...
http://www.genwaybio.com/product_info.php?products_id=83167...

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Corticotropin Releasing Factor antibody (ab11133) | Abcam
Corticotropin-releasing hormone (CRH) is a 41-amino acid peptide derived from ... In addition to production in the hypothalamus, CRH is also synthesized in
...
http://www.abcam.com/corticotropin-releasing-factor-antibody...

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Other Antibody References
Anton PM, Gay J, Mykoniatis A, Pan A, O'Brien M, Brown D, Karalis K, Pothoulakis C (2004) Corticotropin-releasing hormone (CRH) requirement in Clostridium ...
http://www.atsbio.com/reference/ab.html...

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Mouse CRHBP Affinity Purified Polyclonal Ab
Mouse CRHBP is a 37 kDa, monomeric CRH-binding glycoprotein that is ... binds CRH and CRH-like peptides, either serving as an antagonist for CRH ...
http://www.rndsystems.com/pdf/AF3087.pdf...

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Antibodies to Neuropeptides
Crh(12918), pig, human, sheep, frog, rat, canine, mouse, bovine, ARR, IHC (p), RIA, pricing. E1645, Anti-Endothelin antibody produced in rabbit ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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C3042 Corticotropin Releasing Factor human, rat CRF, CRH ≥95% (HPLC)
C3042 Corticotropin Releasing Factor human, rat 95% (HPLC) CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=C304...

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