Gene Information from Publications |
| Publication Link |
Summary of findings |
| 12734882 |
Observational study of gene-disease association. (HuGE Navigator) |
| 14573312 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11140838 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 11555839 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12051390 |
Observational study of gene-disease association. (HuGE Navigator) |
| 12154211 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17676473 |
Network analysis showed that AA have retained an ancestral CRH haplotype, while the most common EA haplotype is derived from a single recombination event. |
| 18212352 |
phorbol ester stimulates CRH gene transcriptional activity through the CRE, suggesting that cross-talk between PKC and protein kinase A signaling pathways targets this regulatory element in placental cells |
| 17693031 |
Acute GES reduces the number of CRF-producing neurons and decreases CRF expression in PVN during post-operative gastric ileus. |
| 17568667 |
findings suggest that CRH augments LPS induced cytokine secretion in human trophoblast cells. Modulation of LPS induced immune responses by CRH may be mediated through regulation of TLR-4 and selective activation of the p38/MAPK signalling pathway. |
| 17959886 |
Corticotrophin-releasing hormone induces ACTHR receptor as potently as ACTH during late gestation. |
| 17766644 |
Data describe the discovery of phosphocholine attached to a number of placental hormones, and notes significant concentrations of immunoreactive CRF and proCRF peptides in rat placental and plasma extracts. |
| 17554801 |
CRH, PLAC1, and selectin-P are distributed differently in preeclampsia cases compared to controls and correlate with signs of preeclampsia. |
| 17667919 |
Corticotropin-releasing hormone produced by ovarian cancer might favour survival and progression of the tumour by promoting its immune privilege. |
| 16523405 |
CRH promoter reactivity varies between the compound promoter alleles. |
| 15883387 |
Ileal-specific CRF promotes inflammation and modulates bowel motility. |
| 14576187 |
human cord blood-derived cultured mast cells (hCBMC) at 10 wk, but not at 2 wk, are immunocytochemically positive for CRH and urocortin |
| 16309788 |
during pregnancy, early detection of stress signals by the placenta stimulate the subsequent release of CRH and may result in increased risk for preterm delivery |
| 17068474 |
CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes |
| 16675846 |
CRH peptides can differentially influence hair follicle melanocyte behavior not only via CRH-R1 signaling but also by complex cross-talk between CRH-R1 and CRH-R2. |
| 12450317 |
CRH exerts inhibitory effects on steroidogenesis in rat and human granulosa cells, acting through the CRH receptor. |
| 14675801 |
An association between an allele of the CRH-linked locus and behavioral inhibtion. Among offspring of parents with panic disorder, this association was marked. |
| 12062896 |
AP-2alpha modulates human corticotropin-releasing hormone gene expression in the placenta by direct protein-protein interaction. |
| 12114295 |
CRH modulates human cardiovascular and pupillary autonomic reflexes. |
| 15591024 |
calcium/calmodulin-dependent protein kinase IV signaling pathway may play an important role in the excitation-mediated regulation of CRH synthesis |
| 14667971 |
progesterone, corticotropin-releasing factor, and activin A have roles in paracrine regulation of endometrial function [review] |
| 16740657 |
Ultraviolet B radiation induces CRH production in human melanocytes through stimulation of the protein kinase A pathway |
| 11406119 |
Findings of slightly diminished cerebrospinal fluid CRH levels after feeding may be accounted for by the rises in glucocorticoids and their associated negative feedback effects on central nervous system CRH. |
| 12583606 |
Placenta takes part in stress syndrome by releasing CRF, which may help to influence uterine perfusion, maternal metabolism, fluid balance, and uterine contractility, protecting fetus from hostile environment.(review) |
| 15077295 |
CRH plays pathogenic role in modulating inflammatory joint disease with CREB/ATF family of transcription factors as principal effector molecules of proinflammatory mediator action in rheumatoid arthritis. |
| 12679466 |
in chorion trophoblast cells, endogenously produced corticotropin-releasing hormone exerts a tonic stimulatory effect on 15-hydroxyprostaglandin dehydrogenase activity |
| 11854458 |
during pregnancy CRH primarily activates intracellular signals that contribute to the maintenance of myometrial quiescence. |
| 16222669 |
CRH genetic alterations could explain several autosomal dominant nocturnal frontal lobe epilepsy clinical features |
| 16984517 |
findings suggest that the increased levels of tumor necrosis factor-alpha and corticotropin-releasing hormone found in pregnant women presenting with preterm labor may be involved in the pathophysiological mechanism of the latter |
| 15126558 |
CRH promoter region between -248 and -213 bp was essential for the effect of both E2 and ICI 182780. This region contains a consensus cAMP regulatory element that is a requirement for E2- and ICI 182780-mediated activity. |
| 15468147 |
CRH inhibited the transition of keratinocytes from G0/1 to S phase of the cell cycle, which was accompanied by an increased expression of cdk inhibitor p16 (Ink4a) protein |
| 11936276 |
The ability of CRH to induce POMC expression in cultured melanoma cells; in CRH positive melanomas, seven out of nine cases (78%) of primary melanoma, and 7 out of 12 cases (58%) of MetM showed colocalization of CRH and POMC peptides |
| 12784189 |
Detected in placenta, myometrium, decidua, and fetal membranes. Widespread expression of CRH system in gestational tissue suggests paracrine role CRH in birth process (e.g. effects on macrophages and endothelial cells). |
| 16245303 |
CRH and related peptides can couple CRH-R1 to any of diverse signal transduction pathways; they also regulate cell viability and proliferation in cell type and growth condition-dependent manners. |
| 15816833 |
CRH regulates IL-18 production through the MAPK signaling pathway in human keratinocytes. |
| 12429558 |
Intraventricular insulin potentiates the anorexic effect of corticotropin releasing hormone in rats |
| 11932939 |
NPY regulates the CRH system of the human hypothalamus and some of the effects of NPY on metabolic, autonomic, and endocrine functions may be mediated through CRH |
| 14698679 |
CRH administration induced sympathotonic effects which were antagonized by ANP |
| 16446741 |
Colocalization of CRH and nuclear/cytoplasmic androgen receptor (AR) was found in neurons of the human hypothalamic paraventricular nucleus (PVN). In the presence of testosterone, recombinant human AR bound to CRH-androgen-responsive elements. |
| 16734917 |
detection of substantial expression of the CRH and its receptor proteins, as well as receptor mRNA in the cervix suggests that the cervix may be a target for CRH action |
| 12853091 |
reduced levels of circulating corticotropin releasing factor were associated with increased uterine artery resistance |
| 14706771 |
Expression of urocortin mRNA is significantly downregulated in the Edinger-Westphal nucleus of CRF-overexpressing transgenic mice compared with wild-type. |
| 15072543 |
The high expression of CRH in placenta and in choriodecidua and myometrium suggested that CRH derived from placenta exerts direct or indirect actions on these tissues. |
| 14675201 |
corticotropin-releasing hormone inhibits nuclear factor-kappaB binding and transcriptional activity. |
| 16639867 |
Nonalcoholic subjects with a family history of alcoholism exhibit lower plasma ACTH and beta-endorphin as well as lower ACTH, cortisol, and beta-endorphin responses to psychological stress and CRH stimulation. |
