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CRHR2


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Gene DB Home
Symbol:CRHR2
Name(s):corticotropin releasing hormone receptor 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:CRFR2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11857585 Observational study of gene-disease association. (HuGE Navigator)
14724656 Observational study of gene-disease association. (HuGE Navigator)
16175604 Observational study of gene-disease association. (HuGE Navigator)
16691126 Observational study of gene-disease association. (HuGE Navigator)
16884458 Observational study of gene-disease association. (HuGE Navigator)
17532191 Observational study of gene-disease association. (HuGE Navigator)
17959885 Human myometrium expresses both CRH-R1 and CRH-R2 during pregnancy.
17532191 results show that haplotype variation at the CRHR2 locus is associated with suicidal behaviour
17463062 in chorion trophoblast cells, CRHR1 and CRHR2 mediate divergent effects on PGDH expression, and this may provide a precise regulation of PGs levels from chorion to myometrium during pregnancy
17170072 Both CRHR1 and CRHR2 play a facilitatory role in the non-clathrin-, non-caveolae-mediated endocytosis and intracellular signal transduction of urocortin.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCorticotropin releasing hormoneHomo sapiens corticotropin releasing hormone receptor type 2 beta isoform mRNA, complete cds.--Pubmed
HPRDcorticotropin releasing hormone precursorCorticotropin releasing hormone receptor 2--Pubmed
HPRDCorticotropin releasing hormone receptor 2urocortin preproprotein--Pubmed
HPRDHomo sapiens corticotropin releasing hormone receptor type 2 beta isoform mRNA, complete cds.Urocortin--Pubmed
HPRDHomo sapiens corticotropin releasing hormone receptor type 2 beta isoform mRNA, complete cds.urocortin preproprotein--Pubmed
HPRDHomo sapiens corticotropin releasing hormone receptor type 2 beta isoform mRNA, complete cds.urocortin 3 preproprotein--Pubmed
HPRDHomo sapiens corticotropin releasing hormone receptor type 2 beta isoform mRNA, complete cds.urocortin 3 preproprotein--Pubmed

Recent Publications on CRHR2:

Pubmed Logo
From QTL to candidate gene: a genetic approach to alcoholism research.
A major focus of research in alcohol-related disorders is to identify the...
17th October, 2009
Department of Psychiatry, Indiana University School of Medicine, Institute Curr Drug Abuse Rev. 2009 May;2(2):127-34.
An intronic polymorphism in the corticotropin-releasing hormone receptor 2 gene increases susceptibility to HBV-related hepatocellular carcinoma in Chinese population.
Corticotropin-releasing hormone receptor 2 (CRHR2) plays a role in both...
9th October, 2009
Department of Laboratory Medicine, Eastern Hepatobiliary Hospital, Second Hum Genet. 2009 Oct 8.
DOI Direct Link
CRH-Like Peptides in Human Reproduction.
CRH and Urocortins 1, 2 and 3 comprise the, so far identified, members of...
17th September, 2009
Laboratory of Human Reproduction, Department of Obstetrics and Gynecology, Curr Med Chem. 2009 Sep 16.
Suppression of progesterone production by stresscopin/urocortin 3 in cultured human granulosa-lutein cells.
BACKGROUND: Corticotropin-releasing hormone (CRH) and its receptors have...
27th August, 2009
Department of Obstetrics and Gynecology, Kobe University Graduate School Hum Reprod. 2009 Jul;24(7):1748-53. Epub 2009 Apr 7.
DOI Direct Link
Enhanced expression of vascular cell adhesion molecule-1 by corticotrophin-releasing hormone contributes to progression of atherosclerosis in LDL receptor-deficient mice.
Peripherally produced corticotrophin-releasing hormone (CRH) is a strong...
26th August, 2009
Department of Pharmacology, Nanjing Medical University, PR China. Atherosclerosis. 2009 Apr;203(2):360-70. Epub 2008 Jun 13.
DOI Direct Link

View more research publications.

Press Releases on CRHR2:

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Advances in the development of corticotropin-releasing-hormone (CRH) 1st January, 1970 Dailyupdates

Patents:

Patents logo
US Patent No.Title
7608701 Corticotropin releasing factor 2 receptor agonists
6936585 Corticotropin releasing factor 2 receptor agonists
7071323 Promoter sequences for corticotropin releasing-factor receptor CRF.sub.2.alpha. and method of identifying agents that alter the activity of the promoter sequences
7192923 Corticotropin releasing factor 2 receptor agonists
7192924 Corticotropin releasing factor 2 receptor agonists

View more patents.

CRHR2 results (if any) from reagent suppliers

Google CSE Logo
CRF-RI/II (C-20) Antibody sc-1757
Human, CRHR2, 1395, 7p15.1, NM_001883 · Q13324 · 602034. Mouse, Crhr1, 12921, 11 E1, P35347, N/A. Mouse, Crhr2, 12922, 6 B3, Q60748 ...
http://www.scbt.com/datasheet-1757-crf-ri-ii-c-20-antibody.h...

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Corticotropin Releasing Factor Receptor 2 antibody (ab75168) | Abcam
Corticotropin Releasing Factor Receptor 2 (CRHR2) expression has been reported in various regions of the brain, as well as in placenta, umbilical vein...
http://www.abcam.com/Corticotropin-Releasing-Factor-Receptor...

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CRF-RII (N-20) Antibody sc-1826
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CRHR2, 1395, 7p15.1, NM_001883 ...
http://www.scbt.com/datasheet-1826-crf-rii-n-20-antibody.htm...

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Imgenex : GPCR Antibodies: Class B Secretin-like
IMG-71245, Corticotropin releasing factor, Corticotropin-Releasing Factor Receptor 2 (CRHR2), Rabbit, pAb, H, IHC-P, 0.05 mg ...
http://imgenex.com/view_data_page.php?id=89...

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CRF-R Antibody / CRF-R Antibodies
PRODUCT NAME, CATALOG #, ISOTYPE, EPITOPE, APPLICATIONS, SPECIES. CRF-RI (V-14) Antibody, sc-12381, goat IgG, internal (h), WB, IF, ELISA, m, r, h, cow ...
http://www.scbt.com/table-crf-r.html...

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PHOENIX PHARMACEUTICALS, INC - Phoenix Peptides
CRH-R2, CRH-R2 selective agonists, Sep 28, 2007. Neuromedin U (NmU), An Endogenous Ligands for Orphan G Protein-coupled Receptor, FM3 and FM4 with
Central ...
http://www.phoenixpeptide.com/catalog/pnxfolist.php?cPath=10...

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SelectScreen® Cell-based GPCR Profiling Services
Corticotropin Releasing Factor, CRHR2, CRE-bla CHO-K1. Dopamine, D1, CRE-bla CHO -K1. Dopamine, D2, Gqo5-NFAT-bla CHO-K1 ...
http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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