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CRKL
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18059481 |
Confocal laser scanning microscopy analysed the distribution and colocalization of CT10 regulator-like (CRKL) p210(BCR-ABL). CRKL-p210(BCR-ABL) foci were completely or partially associated, touching or separate in different regions of the same cell. |
| 17764157 |
Crk L is a bona fide nuclear signaling protein because of its ability to bind tyrosine-phosphorylated STAT5 and act as a transcriptional coactivator. |
| 16305332 |
Results suggest that the interaction of the cytoplasmic tail of CD34 with the shallow proline-rich motif-binding groove of Crk-L is essential for the function of CD34 in stem cell development. |
| 12697763 |
Cbl-b plays a negative role in Crk-L-C3G-mediated Rap1 and LFA-1 activation in T cells. |
| 12522101 |
directs ASAP1 to peripheral focal adhesions in platelets |
| 16289966 |
CD21 activation triggered Cbl tyrosine phosphorylation, which interacts with SH2 domains of p85 subunit, SH2 domains of Crk-L and with tyrosine phosphorylated Syk kinase. CD21 activation triggers dissociation of Cbl-Vav complex. |
| 15522217 |
Data suggest that members of the insulin receptor family activate Crk isoforms Crk-II and Crk-L in a differential manner. |
| 12393632 |
DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines |
| 16955467 |
By lysing primary hemopoietic cells at high pH, BCR-ABL1 protein-degradative activity was inhibited & association between BCR-ABL1 protein in complexes with adaptor proteins CBL, CRKL & GRB2 in primary chronic myeloid leukaemia material was demonstrated |
| 17161365 |
in CRKL, an SH3 domain dimer formed through exchange of the first SH3 domain beta strand and suggest that partial unfolding of the SH3C is important for the relay of information in vivo | →View more information from publications. |
Recent Publications on CRKL: |  |
Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.
Crk family adaptors, consisting of Src homology 2 (SH2) and SH3... | 29th October, 2009
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| J Cell Sci. 2009 Oct 27.
DOI Direct Link |
A BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice.
The BCR-ABL tyrosine kinase is the defining feature of chronic myeloid... | 14th October, 2009
| Division of Hematology and Medical Oncology, Oregon Health & Science
| PLoS One. 2009 Oct 13;4(10):e7439.
DOI Direct Link |
Flow cytometric determination of Src phosphorylation in pediatric patients treated with dasatinib.
Tyrosine kinase inhibitors, such as imatinib, have dramatically improved... | 14th October, 2009
| Division of Pediatrics, MD Anderson Cancer Center, Houston, Texas, USA.
| Pediatr Blood Cancer. 2009 Dec;53(6):1132-5.
DOI Direct Link |
The level of BCR-ABL1 kinase activity before treatment does not identify chronic myeloid leukemia patients who fail to achieve a complete cytogenetic response on imatinib.
Imatinib is currently the first line therapy for newly diagnosed patients... | 26th September, 2009
| Department of Haematology, Hammersmith Hospital, Imperial College London,
| Haematologica. 2009 Jun;94(6):861-4. Epub 2009 Apr 18.
DOI Direct Link |
TOB suppresses breast cancer tumorigenesis.
Transducer of ErbB-2 (TOB) is a member of the TOB/Btg gene family. A role... | 22nd September, 2009
| Lombardi Comprehensive Cancer Center, Georgetown University Medical
| Int J Cancer. 2009 Oct 15;125(8):1805-13.
DOI Direct Link |
→View more research publications. |
CRKL results (if any) from reagent suppliers | 
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Phospho-CrkL (Tyr207) Antibody #3181
Phospho-CrkL (Tyr207) Antibody detects endogenous levels of CrkL only when phosphorylated at tyrosine 207. The antibody cross-reacts with CrkII ...
http://www.cellsignal.com/products/3181.html...
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Abcam - antibodies and reagents, find any antibody
Goat polyclonal to CrkL. Crkl is a 33kDa adaptor protein which has been shown to activate the RAS and JUN kinase signalling pathways and transforms ...
http://www.abcam.com/CrkL-antibody-ab10907.html...
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Anti-CRKL Polyclonal Antibody
Polyclonal Antibody against CRKL for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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Phospho-CrkL (Tyr207) Antibody
amino-terminal SH3 domain of CrkL binds proteins such as. C3G, SOS, PI3K, c-Abl and BCR/Abl. ... Tyr207 of human CrkL. Antibodies are purified by protein A ...
http://www.cellsignal.com/pdf/3181.pdf...
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CrkL antibodies: Chromatin and Nuclear Signaling > Transcription ...
CrkL antibodies. ... CrkL antibody. IP, WB. Rabbit polyclonal. Reacts with: Hu, Ms. Predicted: Rat, Xl, Zfsh. ab32126 · CrkL antibody [Y243]. IHC-P, ICC, WB ...
http://www.abcam.com/index.html?t=53206&pt=1&c=915&ei=&mu=ra...
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CrkL (32H4) Mouse mAb #3182
Monoclonal antibody is produced by immunizing mice with a synthetic peptide (KLH -coupled) corresponding to amino-terminal residues of human CrkL. ...
http://www.cellsignal.com/products/3182.html...
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ORDERING INFORMATION
23 Jul 2008 ... CrkL is a widely-expressed 39 kD adaptor protein that belongs to the Crk ... domains CrkL initiates interactions with numerous downstream ...
http://www.rndsystems.com/pdf/AF5127.pdf...
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