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ADORA3

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Symbol:	ADORA3
Name(s):	adenosine A3 receptor
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	A3AR, AD026, RP11-552M11.7, bA552M11.5
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
17728764	Observational study of gene-disease association. (HuGE Navigator)
17728764	Genetic variants in the adenosine A1/A3 receptor genes may predict the heart's response to ischemia or injury and might also influence an individual's response to adenosine therapy.
12435805	A(3) receptors, in astrocytoma cells, are regulated after short- and long-term agonist exposure.
15849244	biophysical analysis of the effect of surfactants on human adenosine a3 receptor
12152652	involvement in adenosine inhibition of tissue factor expression by LPS-stimulated human monocytes
16242072	A3 receptor stimulation activates p44/p42 and p38 mitogen-activated protein kinases, which are required for A3-induced increase of HIF-1alpha and Ang-2
12406340	adenosine triggers a survival signal via A3 receptor activation and it kills the cell through A2A receptor inducing a signaling pathway that involves protein kinase C and mitogen-activated protein kinases.
15147729	effects of an A3AR agonist, IB-MECA, on the cell growth of human breast cancer cell lines suggest that the inhibitory effect of on the growth of human breast cancer cell lines is mediated through activation of A3 adenosine receptor.
11891221	identification of residues in ligand recognition and activation
12600879	Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors.
→View more information from publications.

Recent Publications on ADORA3:
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. When exposed to a specific microenvironment, macrophages acquire either...	10th September, 2009	Department of Genetic Medicine, Weill Cornel Medical College, New York, NY	J Immunol. 2009 Aug 15;183(4):2867-83. Epub 2009 Jul 27. DOI Direct Link
New bioinformatics approach to analyze gene expressions and signaling pathways reveals unique purine gene dysregulation profiles that distinguish between CD and UC. BACKGROUND: Expression of purine genes is modulated by inflammation or...	2nd September, 2009	Department of Bioinformatics, Ohio State University, Columbus, Ohio 43210,	Inflamm Bowel Dis. 2009 Jul;15(7):971-84. DOI Direct Link
Adenosine receptor protein changes in guinea pigs with form deprivation myopia. Abstract. Purpose: Recent results have shown that treatment with the...	17th July, 2009	State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre,	Acta Ophthalmol. 2009 Jul 14. DOI Direct Link
Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. In asthmatic airways, adenosine is a potent bronchoconstrictor with either...	6th June, 2009	Department of Internal Medicine, Hanyang University College of Medicine,	Respir Med. 2009 Mar;103(3):356-63. Epub 2008 Nov 18. DOI Direct Link
A 57-gene expression signature in B-cell chronic lymphocytic leukemia. B-CLL is the most frequent type of leukemia in the Western countries. The...	13th March, 2009	Dipartimento di Medicina Interna, Scienze Endocrino-Metaboliche e	Biomed Pharmacother. 2009 Nov;63(9):663-71. Epub 2009 Feb 25. DOI Direct Link
→View more research publications.

Clinical Trials:
A Phase 1-2 Study of CF102 in Patients With Advanced Hepatocellular Carcinoma

Patents:
US Patent No.	Title
7588771	Microorganisms for therapy
6407236	Adenosine A3 receptor modulators
6448253	Adenosine A3 receptor modulators
6673908	Tumor necrosis factor receptor 2
6936417	Gene expression in bladder tumors
→View more patents.

ADORA3 results (if any) from reagent suppliers

Cell Line Descriptions GeneBLAzerо ADORA3-Gα15-NFAT-bla CHO-K1 ... Receptor (ADORA3) stably integrated into the GeneBLAzerо Ga15-NFAT-bla CHO-K1 cell line. ... GeneBLAzerо ADORA3-Ga15-NFAT-bla CHO-K1 cells (10000 ... http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf/GP...
Adenosine A3-R (H-80) Antibody sc-13938 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADORA3, 140, 1p13.2, NM_000677, ... http://www.scbt.com/datasheet-13938-adenosine-a3-r-h-80-anti...
656402 2-Fluoroadenosine 97% mp, 240 °C (D)(lit.) Gene Information, human ... ADORA3(140). rat ... Adora1( 29290), Adora2a(25369), Adora3(25370). Safety ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=ja...
Adenosine A3-R (R-18) Antibody sc-7510 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Adora3, 11542, 3 F2.2, Q61618 ... http://www.scbt.com/datasheet-7510-adenosine-a3-r-r-18-antib...
13155 N6-Benzyladenosine puriss., ≥99.0% (HPLC) assay, ≥99.0% (HPLC). mp, 184-186 °C. Gene Information, human ... ADORA3(140). rat ... Adora1(29290), Adora2a(25369), Adora3(25370). storage temp. 2-8°C ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?lang=ja...
Cell-Based GPCR Reporter Assays Adenosine, ADORA3, PDF Download · K1484 · K1503, X. Adenosine, ADORA3, PDF Download · K1837. Adrenoreceptor, ADRA1A, PDF Download ... http://www.invitrogen.com/site/us/en/home/Products-and-Servi...
SelectScreen® Cell-based GPCR Profiling Services Adenosine, ADORA3, U2OS. Adrenoreceptor, ADRA1A, NFAT-bla CHO-K1. Adrenoreceptor , ADRA1B, NFAT-bla CHO-K1. Adrenoreceptor, ADRA2A, Gqo5-NFAT-bla CHO-K1 ... http://www.invitrogen.com/site/us/en/home/Products-and-Servi...

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ADORA3

Gene Information from Publications

Recent Publications on ADORA3:

Clinical Trials:

Patents:

ADORA3 results (if any) from reagent suppliers