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PARP1
| Symbol: | PARP1 | | Name(s): | poly (ADP-ribose) polymerase family, member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ADPRT, ADPRT1, PARP, PARP-1, PPOL, pADPRT-1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18330920 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18347181 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18357393 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18230337 |
Our results indicate that nicotinamide treatment attenuates p21WAF1 expression through Sp1 downregulation, and suggest a possible involvement of nicotinamide metabolism in cellular gene expression. |
| 18025084 |
Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by DNA strand breaks and signals the presence of DNA lesions by attaching ADP-ribose units to chromatin-associated proteins. |
| 18164959 |
caspase-3 activation by RSVL is required for PARP degradation and induction of apoptosis |
| 15705867 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 11591122 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11941587 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12632415 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Recent Publications on PARP1: |  |
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs.
Whereas target-specific drugs are available for treating... | 31st October, 2008
| Division of Molecular Biology and Centre for Biomedical Genetics and.
| Proc Natl Acad Sci U S A. 2008 Oct 29.
DOI Direct Link |
American Chemical Society--236th National Meeting & Exposition. Drug development for tuberculosis and cancer.
Synthetic lethality is an attractive strategy for the design of novel... | 31st October, 2008
| Wyeth Research, CN
| IDrugs. 2008 Oct;11(10):699-701.
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Poly(ADP-ribosyl)ation is implicated in the G0-G1 transition of resting cells.
Poly(ADP-ribosyl)ation, catalysed by a family of poly(ADP-ribose)... | 29th October, 2008
| Pasteur Institute-Fondazione Cenci Bolognetti, Department of Cellular
| Oncogene. 2008 Oct 23;27(47):6083-92. Epub 2008 Jul 28.
DOI Direct Link |
Stratification of paediatric ALL by in vitro cellular responses to DNA double strand breaks provides insight into the molecular mechanisms underlying clinical response.
The molecular basis of different outcomes in paediatric ALL remains poorly... | 23rd October, 2008
| CRUK Institute for Cancer Studies, Birmingham University, Birmingham,
| Blood. 2008 Oct 21.
DOI Direct Link |
The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes.
TRPM2 cation channels are widely expressed in the immune system and are... | 22nd October, 2008
| Department of Pediatrics and Immunology, University of Washington,
| J Biol Chem. 2008 Sep 5;283(36):24571-83. Epub 2008 Jul 3.
DOI Direct Link |
→View more research publications. |
PARP1 results (if any) from reagent suppliers | 
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PARP-1 (F-2) Antibody sc-8007
An NQO1- and PARP-1-mediated cell death pathway induced in ... Western blot analysis of PARP-1 expression in non-transfected: sc-117752 (A) and human PARP-1
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http://www.scbt.com/datasheet-8007-parp-1-f-2-antibody.html...
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PARP1 Antibody (N-term)
Western blot analysis of PARP1 (arrow) using rabbit polyclonal PARP1 Antibody (N -term)(Cat.#AP6373a). 293 cell lysates (2 ug/lane) either nontransfected ...
http://www.abgent.com/products/catalog_no/AP6373a...
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PARP-1 (5A5) Antibody sc-56197
mouse monoclonal IgG1, 100µg/ml; raised against a fragment PARP-1 of human ... Western blot analysis of PARP-1 expression in non-transfected: sc-117752 (A) ...
http://www.scbt.com/datasheet-56197-parp-1-5a5-antibody.html...
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PARP1 Antibody Bethyl Laboratories
PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(+) to an acceptor carboxyl group on ...
http://www.bethyl.com/go/?product/A301-376A/TreeKey=6e57dbd4...
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PARP-1 (6D640) Antibody sc-71849
Western blot analysis of PARP-1 expression in non-transfected: sc-117752 (A) and human PARP-1 transfected: sc-114869 (B) 293T whole cell lysates. Download ...
http://www.scbt.com/datasheet-71849-parp-1-6d640-antibody.ht...
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PARP1 poly (ADP-ribose) polymerase family, member 1
WH0000142M1, Monoclonal Anti-PARP1 antibody produced in mouse clone 3G4, ... P0996, PARP-1 human recombinant, expressed in Escherichia coli ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...
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PARP-1 (H-300) Antibody sc-25780
See how others have used PARP-1 (H-300): sc-25780 and or PARP-1 (H-300) antibody ... Western blot analysis of PARP-1 expression in Jurkat (A) and HeLa + ...
http://www.scbt.com/datasheet-25780-parp-1-h-300-antibody.ht...
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WH0000142M1 Monoclonal Anti PARP1 antibody produced in mouse clone ...
WH0000142M1 Monoclonal Anti-PARP1 antibody produced in mouse clone 3G4, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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PARP-1/2 (H-250) Antibody sc-7150
See how others have used PARP-1/2 (H-250): sc-7150 and or PARP-1/2 (H-250) ... Western blot analysis of PARP-1/2 expression in Jurkat whole cell lysate. ...
http://www.scbt.com/datasheet-7150-parp-1-2-h-250-antibody.h...
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PARP1 IHC Antibody
Anti-PARP1 Antibody, Anti-PARP-1 Antibody, Anti-ADPRT1 Antibody, Anti-PPOL Antibody. ... Affinity purified rabbit anti-PARP1 (Cat. No. IHC-00279) used at
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http://www.bethyl.com/product/pdf/IHC-00279.pdf...
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