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PARP1
| Symbol: | PARP1 | | Name(s): | poly (ADP-ribose) polymerase family, member 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ADPRT, ADPRT1, PARP, PARP-1, PPOL, pADPRT-1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18330920 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18347181 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18357393 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18230337 |
Our results indicate that nicotinamide treatment attenuates p21WAF1 expression through Sp1 downregulation, and suggest a possible involvement of nicotinamide metabolism in cellular gene expression. |
| 18025084 |
Poly(ADP-ribose) polymerase 1 (PARP1) is a nuclear enzyme that is rapidly activated by DNA strand breaks and signals the presence of DNA lesions by attaching ADP-ribose units to chromatin-associated proteins. |
| 18164959 |
caspase-3 activation by RSVL is required for PARP degradation and induction of apoptosis |
| 15705867 |
Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator) |
| 11591122 |
Observational study of gene-disease association. (HuGE Navigator) |
| 11941587 |
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) |
| 12632415 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Recent Publications on PARP1: |  |
Poly(ADP-ribose) polymerase-1 (PARP-1) longer alleles spanning the promoter region may confer protection to bilateral Meniere's disease.
CONCLUSION: The longer alleles (CA)17-20 of the promoter region of PARP-1... | 30th October, 2009
| Otology & Neurotology Group, Department of Otolaryngology, Hospital de
| Acta Otolaryngol. 2009 Nov;129(11):1222-5.
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BMS-536924 sensitizes human epithelial ovarian cancer cells to the PARP inhibitor, 3-aminobenzamide.
OBJECTIVE: To evaluate the anti-neoplastic activity of BMS-536924, an... | 20th October, 2009
| Division of Gynecologic Oncology, Jewish General Hospital, McGill
| Gynecol Oncol. 2009 Nov;115(2):193-8. Epub 2009 Aug 21.
DOI Direct Link |
Pyridine Nucleotide Cycling and Control of Intracellular Redox State in Relation to Poly (ADP-Ribose) Polymerase Activity and Nuclear Localization of Glutathione during Exponential Growth of Arabidopsis Cells in Culture.
Pyridine nucleotides, ascorbate and glutathione are major redox... | 15th October, 2009
| Plant Sciences, Rothamsted Research, Harpenden, Herts, AL5 2 JQ, UK.
| Mol Plant. 2009 May;2(3):442-56. Epub 2009 Mar 23.
DOI Direct Link |
Poly(ADP-ribose) polymerase-1 modulation of in vivo response of brain hypoxia-inducible factor-1 to hypoxia/reoxygenation is mediated by nitric oxide and factor inhibiting HIF.
Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear protein that once... | 10th October, 2009
| Department of Experimental Biology. University of Jaen Paraje Las
| J Neurochem. 2009 Oct;111(1):150-9. Epub 2009 Jul 27.
DOI Direct Link |
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.
Posttranslational modifications play a key role in recruiting chromatin... | 9th October, 2009
| The Stowers Institute for Medical Research, 1000 East 50th Street, Kansas
| Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13770-4. Epub 2009 Aug 6.
DOI Direct Link |
→View more research publications. |
Press Releases on PARP1:
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| MDOUTLOOK(R) Quick Polls Report on Clinical Integration of Key Oncology Developments Following ASCO 2009 |
24th June, 2009 |
The Arcas Group |
ATLANTA, June 24 /PRNewswire/ -- MDOUTLOOK(R), the innovative oncology intelligence platform, today announced the results from its Quick Poll research, which was launched immediately following
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| Investigational Cancer Drug BSI-201 Showed Clinical Benefit in 62% of Patients with Triple-Negative Metastatic Breast Cancer and Significantly Prolonged Survival |
3rd June, 2009 |
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PARIS and BRISBANE, California, June 3 /PRNewswire/ -- Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and its fully
owned subsidiary, BiPar Sciences, today announced results from a randomized
Phase 2
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PARP1 results (if any) from reagent suppliers | 
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