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CSF2RB
| Symbol: | CSF2RB | | Name(s): | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CD131, CDw131, IL3RB, IL5RB | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17362254 |
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) |
| 17667962 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16767694 |
These results suggest that the JAK1-JH7-3 domains are required for interleukin-3 receptor common beta subunit interaction and abolish wild type JAK1 and JAK2-mediated signaling. |
| 15060062 |
Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains |
| 12384414 |
hGM-CSF activation of hGM/beta(c)with or w/o the hbeta(c) subunit, promoted primitive phenotype maintenance, indicating that the hGM Ralpha chain cytosolic domain is needed for differentiation mediated by the hGM Ralpha, beta(c) receptor complex. |
| 12488507 |
JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR |
| 12393492 |
soluble forms of the GM-CSF receptor alpha chain and beta chain were produced and a novel mechanism of receptor assembly was demonstrated |
| 16754968 |
A minor improvement in resolution has given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Colony stimulating factor 2 | colony stimulating factor 2 receptor, beta, low-affinity | - | - | Pubmed |
| HPRD | colony stimulating factor 2 precursor | Interleukin 3 receptor, beta | - | - | Pubmed |
| HPRD | Colony stimulating factor 2 receptor, alpha | colony stimulating factor 2 receptor, beta, low-affinity | - | - | Pubmed |
| HPRD | colony stimulating factor 2 receptor alpha chain isoform a precursor | Interleukin 3 receptor, beta | - | - | Pubmed |
| HPRD | Interleukin 3 receptor, beta | erythropoietin receptor precursor | - | - | Pubmed |
| HPRD | Interleukin 3 receptor, beta | interleukin 3 | - | - | Pubmed |
| HPRD | Interleukin 3 receptor, beta | protein tyrosine phosphatase, non-receptor type 6 isoform 1 | - | - | Pubmed |
| HPRD | Interleukin 3 receptor, beta | tyrosine 3/tryptophan 5 -monooxygenase activation protein, zeta polypeptide | - | - | Pubmed |
| HPRD | Interleukin 3 receptor, beta | SHC transforming protein 1 | - | - | Pubmed |
| HPRD | colony stimulating factor 2 receptor, beta, low-affinity | SHP1 | - | - | Pubmed |
Recent Publications on CSF2RB: |  |
Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk.
Genome-wide association (GWAS) analyses have identified susceptibility... | 6th June, 2009
| Department of Psychological Medicine, School of Medicine, Cardiff
| Mol Psychiatry. 2009 Mar;14(3):252-60. Epub 2008 Dec 9.
DOI Direct Link |
Association study of CSF2RB with schizophrenia in Irish family and case - control samples.
Colony stimulating factor 2 receptor, beta (CSF2RB) is the shared subunit... | 9th April, 2009
| Department of Psychiatry and Virginia Institute for Psychiatric and
| Mol Psychiatry. 2008 Oct;13(10):930-8. Epub 2007 Jul 31.
DOI Direct Link |
Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population.
Schizophrenia has been observed to be associated with various... | 27th September, 2008
| Research Center for Neuroscience and MH Radiobiology Research Unit, Jilin
| Neurosci Lett. 2008 Jul 25;440(1):35-7. Epub 2008 May 15.
DOI Direct Link |
Crystallization and preliminary X-ray diffraction analysis of the ternary human GM-CSF receptor complex.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a... | 22nd August, 2008
| Biota Structural Biology Laboratory, St Vincent's Institute of Medical
| Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Aug 1;64(Pt
DOI Direct Link |
Schizophrenia susceptibility genes directly implicated in the life cycles of pathogens: cytomegalovirus, influenza, herpes simplex, rubella, and Toxoplasma gondii.
Many genes implicated in schizophrenia can be related to glutamatergic... | 17th June, 2008
| 176 Downs Road, Hastings,
| Schizophr Bull. 2009 Nov;35(6):1163-82. Epub 2008 Jun 13.
DOI Direct Link |
→View more research publications. |
CSF2RB results (if any) from reagent suppliers | 
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14-3-3 BETA antibody, 14-3-3 BETA Antibody, Rabbit Polyclonal Antibody
Summary: CSF2RB is a common beta chain of the high affinity receptor for IL-3, ... Defective CSF2RB has been reported to be associated with protein alveolar
...
http://www.genwaybio.com/product_info.php?products_id=78339...
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IL-3Rβ (K-19) Antibody sc-677
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CSF2RB, 1439, 22q12.3, NM_000395 ...
http://www.scbt.com/datasheet-677-il-3rbeta-k-19-antibody.ht...
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Phospho-IL3R-Y593 Antibody Blocking Peptide
Cytokine receptor common beta chain [Precursor]; GM-CSF/IL-3/IL-5 receptor common beta-chain; CD131 antigen; CDw131 antigen; CSF2RB; IL3RB; IL5RB; ...
http://www.abgent.com/products/catalog_no/BP3132a_Phospho_IL...
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IL-3Rβ (T-20) Antibody sc-679
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Csf2rb, 12983, 15 E1, P26955 ...
http://www.scbt.com/datasheet-679-il-3rbeta-t-20-antibody.ht...
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Search Results
JAX Mice Database - 005963 B6.129S1-Csf2rb2 Csf2rb/J. Stock# - 005963 Strain name - B6.129S1-Csf2rb2 Csf2rb/J JAX® Mice ...
http://www.jax.org/search/Main.jsp?sg=0&qt=nomenclature&page...
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CD Marker Products - R&D Systems
CD131, Common beta Chain, CSF2RB, GM-CSF R beta, IL-5 R beta, 1439. CD132, Common gamma Chain, IL-2 R gamma, 3561. CD134, OX40, ACT-135, TNFRSF4, 7293 ...
http://www.rndsystems.com/cdmarker.aspx...
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