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CSK


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Gene DB Home
Symbol:CSK
Name(s):c-src tyrosine kinase
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC117393
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17491594 c-Src is recruited by AF-6 to cell-cell contact sites, suggesting that c-Src is regulated by a PDZ protein in special cellular locations.
18039857 C terminus of c-Src via its Gly-Glu-Asn-Leu sequence presents a mechanism that restricts c-Src in epithelia and prevents progression toward an invasive phenotype
17936276 The interaction of c-Src with LNX1 depends on the C-terminal PDZ ligand of c-Src.
17692281 Thus, these results suggest that endogenous c-Src, c-Yes, and Lyn are differentially activated through Cdc2 activation during M phase.
17936985 A full-length encoding cDNA of the tyrosine kinase csk gene of human lymphocytes was cloned.
17691821 These results demonstrate that the chimeric strategy is useful for detailed dissection of the mechanistic basis of substrate specificity and regulation of protein tyrosine kinases.
17525734 Csk is activated by increase of p140Cap which leads to inhibition of Src and downstream signalling as well as of cell motility and invasion
12686554 functions of the activation loop in phosphorylation of its physiological substrate Src probed by extensive site-specific mutagenesis and kinetic studies
16135530 this study reveals a mechanism by which Src family kinases may control PDGF-mediated responses both at transcriptional and translational levels.
15743820 Csk tyrosine kinase interacts with G3BP, a new player in T-cell-antigen receptor signaling, which reduces the amount of Csk in the immune synapse.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBeta arrestin 1c-src tyrosine kinase--Pubmed
HPRDarrestin beta 1 isoform ACsk--Pubmed
HPRDCaveolin 1c-src tyrosine kinase--Pubmed
HPRDcaveolin 1Csk--Pubmed
HPRDCBLc-src tyrosine kinase--Pubmed
HPRDT-cell antigen receptor, zetac-src tyrosine kinase--Pubmed
HPRDT-cell receptor zeta chain isoform 1 precursorCsk--Pubmed
HPRDCD44 antigenc-src tyrosine kinase--Pubmed
HPRDCD44 antigenc-src tyrosine kinase--Pubmed
HPRDCD44 antigen isoform 1 precursorc-src tyrosine kinase--Pubmed

Recent Publications on CSK:

Pubmed Logo
The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage.
The pathophysiological functions of proline-glutamic acid...
3rd November, 2009
*Centre for DNA Fingerprinting and Diagnostics (CDFD), Nampally, J Immunol. 2009 Oct 30.
DOI Direct Link
Cbp Recruitment of Csk Into Lipid Rafts is Critical to c-Src Kinase Activity and Bone Resorption in Osteoclasts.
Abstract A tyrosine kinase c-Src, which plays an indispensable role in...
31st October, 2009
J Bone Miner Res. 2009 Oct 29.
DOI Direct Link
In this issue.
TRIPLE TAG TECHNIQUE TURNS UP TIGHT AND LOOSE COMPLEXES: pp. 4934-4943The...
29th October, 2009
Proteomics. 2009 Oct 27;9(21).
DOI Direct Link
Cannabinoid receptor type 1 and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.
The aim of this study was to characterize inhibitory mechanisms on T cell...
28th October, 2009
University of Magdeburg, Germany. J Biol Chem. 2009 Oct 26.
DOI Direct Link
The adaptor protein EBP50 is important for localization of the protein kinase A-Ezrin complex in T cells and the immunomodulating effect of cAMP.
We recently reported that the dual-specific A kinase anchoring protein...
28th October, 2009
Biochem J. 2009 Oct 26.
DOI Direct Link

View more research publications.

Press Releases on CSK:

BioPortfolio Logo
BetterInvesting Magazine Releases January Stock to Study and Undervalued Stock Choices for Investors' Informational and Educational Use 30th October, 2009 BetterInvesting Magazine

MADISON HEIGHTS, Mich., Oct. 30 /PRNewswire/ -- The Editorial Advisory and Securities Review Committee of BetterInvesting Magazine

BioNews Results for CSK

: RSS Logo
BioPortfolio Logo
Centralsjukhuset i Karlstad to install Ascoms quiet calling and personal alarm systems
News-Medical.Net:  Nov 4 2009 1:19PM Matching: csk

Clinical Trials:

Clinical Trials Logo
Treatment of Depressed Adolescents With Physical Illness

Patents:

Patents logo
US Patent No.Title
7554537 Booster circuit, semiconductor device, and display device
7576090 Benzazole analogues and uses thereof
7579356 Thia-tetraazaacenaphthylene kinase inhibitors
7579473 c-Met modulators and methods of use
7580529 Method for verifying digital franking notes

View more patents.

CSK results (if any) from reagent suppliers

Google CSE Logo
Csk Antibody / Csk Antibodies
Csk Antibody / Csk Antibodies. ... Csk specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-csk.html...

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Product Unavailable: Csk Antibody #4965
We're sorry but the product you searched for: Csk Antibody #4965 is no longer available. For more information about this product or alternative products, ...
http://www.cellsignal.com/products/4965.html...

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CSK antibody (ab54684) | Abcam
Mouse monoclonal to CSK. C terminal Src kinase (CSK) is a non receptor protein tyrosine kinase. One of its major functions is to specifically phosphorylate ...
http://www.abcam.com/CSK-antibody-ab54684.html...

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Anti-Csk Polyclonal Antibody
Polyclonal Antibody against Csk for use in Immunohistochemistry (Paraffin), Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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Csk (C-20) Antibody sc-286
See how others have used Csk (C-20): sc-286 antibody and or Csk (C-20) antibody ... Western blot analysis of Csk p50 expression in Jurkat whole cell lysate. ...
http://www.scbt.com/datasheet-286-csk-c-20-antibody.html...

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CSK Antibody (C-term)
Western blot analysis of anti-CSK Pab (Cat. #AP7700b) in HL-60 cell lysate. CSK (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used ...
http://www.abgent.com/products/catalog_no/AP7700b_CSK_Antibo...

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Csk (6A399) Antibody sc-70889
Csk shRNA (h) Lentiviral Particles, sc-39161-V, 200 µl ... Csk (6A399): sc-70889 . Western blot analysis of Csk expression in Jurkat whole cell lysate. ...
http://www.scbt.com/datasheet-70889-csk-6a399-antibody.html...

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