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VCAN


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Symbol:VCAN
Name(s):versican
Type:protein-coding
Organism:Homo sapiens
Synonyms:CSPG2, DKFZp686K06110, ERVR, PG-M, WGN, WGN1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16917090 Observational study of gene-disease association. (HuGE Navigator)
17097211 versican in the umbilical cord vein wall is elevated in pre-eclampsia in comparison to the corresponding control vessels
17728259 Using transient transfection assays in prostate cancer LNCaP and HeLa cells engineered to express the AR, study shows that synthetic androgen R1881 and dihydrotestosterone stimulate expression of a versican promoter-driven luciferase reporter vector.
12972299 All melanoma cell lines with an early or intermediate degree of differentiation expressed V0 and V1 versican isoforms, whereas V2 and V3 expression was shown only by undifferentiated cell lines.
15522894 PG-M/versican binds to P-selectin glycoprotein ligand-1 and has a role in mediating leukocyte aggregation
15748997 versican plays an important role in reducing oxidant injury through an enhancement of cell-matrix interaction
12888576 versican/PG-M binds to hyaluronan
17453002 TGF-beta2 triggers the malignant phenotype of high-grade gliomas by induction of migration, and that this effect is, at least in part, mediated by versican V0/V1.
14724283 the interaction between versican and hyaluronan in many tissues is stabilized by Link protein
16431924 Versican G3 domain promotes blood coagulation through suppressing the activity of tissue factor pathway inhibitor-1

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCD44 antigenversican--Pubmed
HPRDCD44 antigenversican--Pubmed
HPRDCD44 antigen isoform 1 precursorversican--Pubmed
HPRDhyaluronan and proteoglycan link protein 1versican--Pubmed
HPRDhyaluronan and proteoglycan link protein 1versican--Pubmed
HPRDVersicantenascin R--Pubmed
HPRDversicanTenascin R--Pubmed
HPRDversicanfibrillin 1--Pubmed
HPRDversicanfibrillin 1--Pubmed
HPRDversicanphospholipase A2, group IIA--Pubmed

Recent Publications on VCAN:

Pubmed Logo
Association analysis of genes involved in the maintenance of the integrity of the extracellular matrix with intracranial aneurysms in a Japanese cohort.
BACKGROUND: An association between versican (CSPG2), perlecan (HSPG2),...
25th September, 2009
Department of Neurology, Rudolf Magnus Institute of Neuroscience, Utrecht, Cerebrovasc Dis. 2009;28(2):131-4. Epub 2009 Jun 5.
DOI Direct Link
NG2 and phosphacan are present in the astroglial scar after human traumatic spinal cord injury.
BACKGROUND: A major class of axon growth-repulsive molecules associated...
17th September, 2009
Department of Neurology, Aachen University Medical School, RWTH Aachen, BMC Neurol. 2009 Jul 15;9:32.
DOI Direct Link
Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves.
INTRODUCTION: Extracellular matrix changes occur in many heart valve...
11th September, 2009
Department of Bioengineering, Rice University, 6100 Main Street, Houston, Cardiovasc Pathol. 2009 Jul-Aug;18(4):191-7. Epub 2008 Jul 14.
DOI Direct Link
Genetic variants A1826H and D2937Y in GAG-beta domain of versican influence susceptibility to intestinal-type gastric cancer.
PURPOSE: Versican regulates adhesion, migration, proliferation, and...
6th August, 2009
Department of Biological Sciences, Korea Advanced Institute of Science and J Cancer Res Clin Oncol. 2009 Aug 5.
DOI Direct Link
The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts.
Heparan sulfate proteoglycans cooperate with basic fibroblast growth...
15th July, 2009
Department of Cell Biology and Cancer Center, University of Massachusetts J Cell Biochem. 2009 May 1;107(1):144-54.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7524611 Photosensitive polymeric material for worm optical data storage with two-photon fluorescent readout
5846959 Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
5508949 Fast subband filtering in digital signal coding
5421026 Data processor for processing instruction after conditional branch instruction at high speed
5410188 Enhanced integrated waveshaping circuit

View more patents.

VCAN results (if any) from reagent suppliers

Google CSE Logo
V5639 Anti-Versican V0/V1 Neo antibody produced in rabbit affinity ...
species reactivity, human, mouse, rat. application(s), immunoblotting: 1 μg/mL using mouse cumulus oocyte complexes. Gene Information, human ... VCAN(1462) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=V563...

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versican (C-18) Antibody sc-26707
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, VCAN, 1462, 5q14.3, NM_004385 ...
http://www.scbt.com/datasheet-26707-versican-c-18-antibody.h...

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Antibodies to Extracellular Matrix Proteins
Vcan(13003), human, mouse, rat, WB, pricing. S2819, Anti-phospho-Syndecan-4 ( pSer179) antibody produced in rabbit, (polyclonal), affinity isolated antibody
...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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human Annexin V antibody, Cytokine Kits conjugate
Annexin V can only be used as a marker of apoptosis in cells where the plasma membrane is intact because destroying the integrity of the plasma membrane ...
http://www.ebioscience.com/ebioscience/specs/antibody_88/88-...

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Monoclonal Anti-Factor V antibody produced in mouse (F2145 ...
Factor V can also be activated by factor Xa. Assays of factor V levels are useful for detection of hereditary and acquired deficiency states and for ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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Human Annexin V ELISA BMS252 BMS252TEN
Total endogenous annexin V can be detected with the present ELISA which will offer further insights in the pathophysiological role of Annexin V (5). ...
http://www.bendermedsystems.com/bm_products/MAN/252.pdf...

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Prestige Antibodies®
Anti-VCAN rabbit affinity isolated antibody. VCAN, human human. IHC (p). PA. HPA004726-100UL. Anti-VIM rabbit affinity isolated antibody. VIM, human ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General_...

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