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ADRA1B


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Symbol:ADRA1B
Name(s):adrenergic, alpha-1B-, receptor
Type:protein-coding
Organism:Homo sapiens
Synonyms:ADRA1, ALPHA1BAR
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12023679 Observational study of gene-disease association. (HuGE Navigator)
15824464 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
16645408 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18257748 ADRA1B expression was increased in end stage renal disease. Functional receptor changes mediated vascular hypersensitivity to phenylephrine.
17681068 In the proximal and medial ureter, the distribution of ARs was alpha 1d > or = alpha 1a > alpha 1b; In the distal ureter, the distribution of ARs was alpha 1d > alpha 1a > alpha 1b
17365508 alpha1B-ARs are the major alpha1-AR subtype expressed in DU145, PC3, and all TRAMP cell lines, but most of the receptor is localized in intracellular compartments in a nonfunctional state, which can be rescued upon prolonged incubation with any ligand.
15297446 alpha(1B)-adrenergic receptor expression causes a cell cycle progression and may induce transformation in sensitive cell lines.
17220353 the ADRA1B is able to form oligomeric rather than only simple dimeric complexes and disruption of effective oligomerization by introducing mutations into transmembrane domain IV has profound consequences for cell surface delivery and function
14736874 heterodimerization with alpha1B-adrenergic receptors controls cell surface expression of alpha1D-adrenergic receptors
14626446 These studies suggest that gC1qR interacts specifically with alpha1B- and alpha1D-, but not alpha1A-ARs, and this interaction depends on the presence of an intact C-tail.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDalpha-1B-adrenergic receptorS-arrestin--Pubmed
HPRDalpha-1B-adrenergic receptorS-arrestin--Pubmed
HPRDalpha-1B-adrenergic receptorguanine nucleotide binding protein, alpha 11--Pubmed
HPRDalpha-1B-adrenergic receptorguanine nucleotide binding protein, alpha 11--Pubmed
HPRDalpha-1B-adrenergic receptorsignal transducer and activator of transcription 1 isoform alpha--Pubmed

Recent Publications on ADRA1B:

Pubmed Logo
Cloning, expression and immunolocalization of alpha1-adrenoceptor in different tissues from rhesus monkey and human male reproductive tract.
This study reports the genomic organization of the rhesus...
17th July, 2008
Section of Experimental Endocrinology, Department of Pharmacology, Mol Hum Reprod. 2008 Feb;14(2):85-96. Epub 2008 Jan 19.
DOI Direct Link
Frequent reduced expression of alpha-1B-adrenergic receptor caused by aberrant promoter methylation in gastric cancers.
Recent studies have suggested that epigenetic inactivation of...
6th March, 2007
Department of Molecular Diagnosis, Japanese Foundation for Cancer Br J Cancer. 2007 Jan 29;96(2):383-90.
DOI Direct Link
Association study of the adrenergic receptors and childhood-onset mood disorders in Hungarian families.
The adrenergic system has been implicated in the etiology of depression...
31st May, 2006
Toronto Western Research Institute, University Health Network, Toronto, Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5;141B(3):227-33.
DOI Direct Link
Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.
An alpha1-adrenergic receptor (alpha1-AR) antagonist increased heart...
17th May, 2006
Cardiology Division, San Francisco Veterans Affairs Medical Center, San J Clin Invest. 2006 Apr;116(4):1005-15.
DOI Direct Link
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics.
The response of blood pressure to thiazide diuretics (TZDs) differs among...
16th July, 2005
Division of Hypertension and Nephrology, National Cardiovascular Center, Hypertens Res. 2004 Nov;27(11):821-33.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia

Patents:

Patents logo
US Patent No.Title
7592325 Methods and compositions for the treatment of eye disorders with increased intraocular pressure
7588767 Microorganisms for therapy
7447594 Molecular cardiotoxicology modeling
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
6875570 Proteins and nucleic acids encoding same

View more patents.

ADRA1B results (if any) from reagent suppliers

Google CSE Logo
ADRA1B - R&D Systems
ADRA1B, also known as the alpha-1B-adrenergic receptor, is a 7TM catecholamine receptor with selectivity for epinephrine and norepinephrine. ...
http://www.rndsystems.com/molecule_detail.aspx?m=3852...

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Neurobiology Antibodies :: Page 1
Adiponectin Antibody, 3553, H, M, R, E, WB, IHC, (NT) A novel adipokine. ADRA1B Antibody, 48-309, H, E, IHC, Alpha 1b-Adrenoceptor. ADRA1B Antibody, 48-310 ...
http://www.prosci-inc.com/shop/catalog1/Neurobiology-Antibod...

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α1B-AR (N-20) Antibody sc-27136
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ADRA1B, 147, 5q33.3, NM_000679 ...
http://www.scbt.com/datasheet-27136-alpha1b-ar-n-20-antibody...

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Signal Transduction Antibodies :: Page 2
ADRA1B Antibody, 48-309, H, E, IHC, Alpha 1b-Adrenoceptor. ADRA1B Antibody, 48- 310, H, IHC, Alpha 1b-Adrenoceptor. ADRB3 Antibody, 46-623, H, E, WB, ADRB3 ...
http://www.prosci-inc.com/shop/catalog1/Signal-Transduction-...

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Monoclonal Antibodies - find any Antibody at Fitzgerald-fii.com
Alpha 1b-Adrenoceptor (ADRA1B), Human. New Catalog#: 20R-AR034. Host Species: Rabbit ... Alpha 1b-Adrenoceptor (ADRA1B), Human. New Catalog#: 20R-AR035 ...
http://www.fitzgerald-fii.com/Products?pId=8...

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Antibodies to Neurotransmitter Receptors
ADRA1B(147), human, IHC (p), pricing. A4604, Anti-α1C Adrenergic Receptor antibody produced in rabbit, (polyclonal), affinity isolated antibody ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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Crystal Reports - P20 - Polyclonal Antibody Data Sheet
Alpha 1b-Adrenoceptor (ADRA1B), Human. Specific for C-terminal cytoplasmic domain of human. Purified by Immunoaffinity Chromatography in PBS containing 0.1
% ...
http://www.fitzgerald-fii.com/uploadDocs/dataSheets/183.pdf...

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