Sunday November 22 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

CTGF


Suggest Content
Advertise Here
Gene DB Home
Symbol:CTGF
Name(s):connective tissue growth factor
Type:protein-coding
Organism:Homo sapiens
Synonyms:CCN2, HCS24, IGFBP8, MGC102839, NOV2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17602195 CTGF is a functional target of aldosterone in mesangial cells, but aldosterone-induced CTGF gene expression is not directly mediated by the mineralocorticoid receptor.
15039132 Observational study of gene-disease association. (HuGE Navigator)
16501850 Observational study of gene-disease association. (HuGE Navigator)
16858645 Observational study of gene-disease association. (HuGE Navigator)
17375628 Observational study of gene-disease association. (HuGE Navigator)
17881752 Observational study of gene-disease association. (HuGE Navigator)
17681742 Basal expression of collagen, fibronectin and CCN2 and adhesion to matrix was not affected
17915216 These data reveal a novel function for CTGF in the regulation of epithelial tissue repair beyond its established role in fibrosis, and further highlight the complexity of TGFbeta regulation of epithelial cell function.
17944991 CTGF mRNA expression was induced in HUVSMCs after treatment with dl-homocysteine (50 micromol L(-1)) for 1 h, which remained at the elevated level for up to 8 h.
17951630 the interaction of CTGF and beta-catenin-TCF/Lef forms a positive feedback loop, which could contribute to the tumorigenicity of ESCC.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDConnective tissue growth factorlow density lipoprotein-related protein 1--Pubmed
HPRDconnective tissue growth factorLow density lipoprotein receptor-related protein 1--Pubmed
HPRDconnective tissue growth factorHuman transforming growth factor-beta-2 mRNA, and translated products--Pubmed
HPRDconnective tissue growth factorHuman transforming growth factor-beta-2 mRNA, and translated products--Pubmed
HPRDconnective tissue growth factortransforming growth factor, beta 1--Pubmed
HPRDconnective tissue growth factortransforming growth factor, beta 1--Pubmed
HPRDconnective tissue growth factortransforming growth factor, beta 3--Pubmed
HPRDconnective tissue growth factortransforming growth factor, beta 3--Pubmed
HPRDconnective tissue growth factorvascular endothelial growth factor--Pubmed
HPRDconnective tissue growth factorvascular endothelial growth factor--Pubmed

Recent Publications on CTGF:

Pubmed Logo
Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts.
OBJECTIVE: Myofibroblasts are the principal mesenchymal cells responsible...
31st October, 2009
Medical University of South Carolina, Charleston. Arthritis Rheum. 2009 Oct 29;60(11):3455-3464.
DOI Direct Link
Cyclical cell stretching of skin-derived fibroblasts downregulates connective tissue growth factor (CTGF) production.
Delayed healing of skin wounds can be caused by wound instability, whereas...
30th October, 2009
Department of Plastic, Reconstructive and Esthetic Surgery, Chiba Connect Tissue Res. 2009;50(5):323-9.
[Effects of small interfering RNA targeting connective tissue growth factor on high glucose-induced human tubular epithelial hypertrophy.]
OBJECTIVE: To observe the effect of transfection with small interfering...
29th October, 2009
Department of Nephrology, Zhujiang Hospital, Southern Medical University, Nan Fang Yi Ke Da Xue Xue Bao. 2009 Oct;29(10):2002-6.
Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor alpha and disuse.
Loading-related changes in gene expression in resident cells in the tibia...
28th October, 2009
Department of Veterinary Basic Sciences, The Royal Veterinary College, Bone. 2009 Oct 24.
DOI Direct Link
TGF-beta inhibits IL-1beta-activated PAR-2 expression through multiple pathways in human primary synovial cells.
ABSTRACT: To investigate the mechanism how Transforming growth factor-beta...
27th October, 2009
J Biomed Sci. 2009 Oct 23;16(1):97.
DOI Direct Link

View more research publications.

BioNews Results for CTGF

: RSS Logo
BioPortfolio Logo
Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts
MDLinx:  Nov 11 2009 9:16AM Matching: ctgf
FibroGen Announces New Research in Anti-CTGF and HIF-PHI Therapeutic Development Programs in Kidney Disease
NewsBlaze:  Nov 2 2009 8:15PM Matching: ctgf
FibroGen Announces New Research in Anti-CTGF and HIF-PHI Therapeutic Development Programs in Kidney Disease
Pharma Live:  Nov 2 2009 10:07PM Matching: ctgf

Clinical Trials:

Clinical Trials Logo
Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion

Patents:

Patents logo
US Patent No.Title
7449554 Antibodies against the PRO4977 polypeptides
7498299 Procollagen (III) propeptides and related substances for treating fibrotic diseases
7498332 Therapy for cerebral vasospasm
7504484 Antibodies to the PRO1561 polypeptide
7507712 NOV protein: an anti-angiogenic agent and its use, in particular for the treatment of cancer

View more patents.

CTGF results (if any) from reagent suppliers

Google CSE Logo
CTGF antibody (ab6992) | Abcam
6 Jan 2006 ... Rabbit polyclonal to CTGF. CTGF (connective tissue growth factor) is a 38kDa, cysteine-rich, secreted peptide.
http://www.abcam.com/CTGF-antibody-ab6992.html...

Thumbshot
CTGF Antibody / CTGF Antibodies
Santa Cruz Biotechnology offers polyclonal antibodies to Connective tissue growth factor (CTGF). CTGF (Connective tissue growth factor) siRNAs are also ...
http://www.scbt.com/table-ctgf.html...

Thumbshot
Anti-CTGF Polyclonal Antibody
Polyclonal Antibody against CTGF for use in Immunoprecipitation, Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

Thumbshot
CTGF Antibody Anti-Human CTGF
CTGF lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20˚C. Reconstitute in sterile water
...
http://www.prosci-inc.com/shop/catalog1/CTGF-Antibody-p-1942...

Thumbshot
CTGF (6B13) Antibody sc-101586
mouse monoclonal IgG1, 100 µg/ml; raised against recombinant CTGF of human ... Western blot analysis of CTGF expression in non-transfected: sc-117752 (A) ...
http://www.scbt.com/datasheet-101586-ctgf-6b13-antibody.html...

Thumbshot
CTGF Antibody Biotin - Anti-Human CTGF
CTGF lyophilized antibody is stable for at least 6 months when kept at -20˚C. The biotinylated antibody should be reconstituted to a concentration of 50 ...
http://www.prosci-inc.com/shop/catalog1/CTGF-Antibody-p-1942...

Thumbshot
CTGF (C-19) Antibody sc-14940
CTGF shRNA (h) Lentiviral Particles, sc-39329-V, 200 µl ... See how others have used CTGF (C-19): sc-14940 antibody and or CTGF (C-19) antibody conjugates. ...
http://www.scbt.com/datasheet-14940-ctgf-c-19-antibody.html...

Thumbshot

Search Bioportfolio and other Life Science Sites for CTGF, or search for CTGF on BioPortfolio's antibody search engine.
This page has been viewed 725 times
Recent Search Terms used to find this page:
study of thrombin gene expression in dabigatran | sc-73869 | ctgf antibody | connective tissue growth factor secretory protein | ctgf results | CTGF and cytokine | ctgf | ncbi CTGF function | CTGF (Connective Tissue Growth Factor) | .


Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.